I plan to start Rapa tomorrow, me and my dog. I have a few questions. Up to now, among other things, I’ve been using supplements to mitigate aging and extend lifespan. Are there any supplements that should be reduced or stopped while taking Rapa, perhaps contraindicated? This same question applies to foods. The reverse of this question is also pertinent: supplements/foods beneficial when taken with Rapa?
I’ve also become a bit confused as to what the consensus is in regard to dosing. While following experts like Dr. Green and Blagosklonny it seems to jump back and forth regarding dosage, and timing (daily, weekly, every two weeks . . )
Congratulations on the start of your adventure! May it go smoothly into the far future.
If you haven’t be sure sure to read the extensive FAQs, which includes other anti-aging supplements:
As far as contraindicated supplements, there is little evidence that intermittent dosing interferes with much of anything except partially with mTORC1. If you have a condition in which a slight immune suppression could be an issue, be sure to monitor your blood results for low white blood cells.
We don’t know the perfect dosage schedule, and it surely is individualized. Look at what others are doing and slowly transition your dosage to your goal, and consider taking hiatuses. Measure your trough levels of rapa so that your blood levels are truly intermittent and not too high.
Good advice from EnrQay.
Wander through the forum and the FAQ and you will learn much of what you need to know.
In general, I think most people start out pretty low, 6mg per week is where I started, gradually increasing my dosage over time as I had no side effects.
There are supplements that interact with rapamycin and because of that interaction may affect your effective dosage. I personally avoid or restrict their use. Curcumin and DIM are two supplements that I used to take regularly but I now limit due to their interaction.
Slow and sure is my plan. As for blood testing, I know for a fact that my physician would refuse. He refused to look at the science when I brought it up so I’m flying solo. I’ve had my doc for decades and finding a new one would be difficult. He’s in my age group and all other local Doc’s are not taking on new clients - especially seniors. I’m in Canada by the way, the country that discovered Rapa, but our ability to legally get it is difficult. I took a chance and successfully managed to source Sirolimus from India.
I am not talking about any special blood test, just the standard ones that most doctors look at anyway… the “bio age calculations” are free - so this is what I use just as an ongoing reference point as I track my progress over the years and test different supplements or drugs.
Creactive protein, etc…
The blood test variables use in a well-validated “biological age” calculation developed at Yale University uses these variables:
Its interesting - other forum members from Canada have commented not only on how easy it can be to get some blood testing in Canada, but in the case of testing “blood sirolimus” levels - the even get the testing fully covered by the government… see this post:
More details on testing for blood sirolimus levels and why you may want to do it: