Thanks for sharing, EnrQay. Was this peak result at a dose of 3mg/wk of Sirolimus (with grapefruit juice protocol)? Are you taking it with a source of fat or on an empty stomach?
The trough was 3mg/wk, while the peak was 5mg/wk, both with whole grapefruit. In both cases, I took the rapa at the same time as a fatty snack of peanuts and a fatty hot chocolate.
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I’ve been using Ulta Labs (ultalabtests) for ordering tests for 5 years now. Excellent prices! They work with Quest Diagnostic for a draw fee of $8.
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Wow - really, those prices are amazingly low. They are much lower than the already low Life Extension labs pricing - again, just a front end for Quest or Labcorp.
I priced a few tests that might be of interest to people here, comparing it to my default, walkinlab.com (which partners with the labs Labcorp and Quest). Mostly, ultalabtests is significantly lower, and I see an associated lab site as close to me as Labcorp and Quest.
sirolimus: Ult (standard order, so it’s a bit easier to order) $118, LEF (special order) $99
CRP-hs: Ult $29, WIL (LC $58, Q$32)
standard lipid panel: Ult $21 , WIL ($28)
Complete Blood Count (CBC) and Comprehensive Metabolic Panel: Ult: $38, WIL(LC $46, Q $44)
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I am almost ashamed to say, but here in Canada, I am getting my Sirolimus tests done for free. The government must deem Sirolimus associated with cancer/transplantation, and covers it. So I am flying under the radar with my very supportive functional medicine doc (NOT regular mainstream family doc who I fired years ago).
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Wow - thats fantastic. Something every Canadian rapamycin fan will be glad to know.
It would be great if you could do a series of blood sirolimus tests after different doses and at different times (e.g. 1 hour after consumption, 12 hours, 24 hours…)
You could get a really good idea of what your dose/response curve looks like and how different compounds like grapefruit juice change that curve.
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Yes, that’s my plan. Will post the outcome.
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It seems only appropriate that since Rapamycin was discovered by Canadians, that Canadians should be the ones pushing the clinical applications for anti-aging forward with additional testing like this 
In all seriousness - I do think that countries like Canada actually are the best positioned to invest in something like rapamycin, in research and in rolling it out aggressively to their population to slow the burden of age-related dysfunction and disease, because ultimately the biggest beneficiary would be the Canadian people, and the healthcare budget. It would seem that there is the incentive to move the fastest in countries that have universal health insurance.
Of course - there is the problem of the slowness of government, but Canadians should really push it.
For those interested - there is a book on the initial Canadian expedition to Easter Island that found the bacterium which secreted a compound, which we now call Rapamycin. I found out about it from Laura Minquini’s article I link to on the home page.
“Dreamed up” by McGill University’s surgeon Stanley Skoryna and microbiologist Georges Nó grády in 1962, the project was to provide medical and biological profiles of Easter Island (also known by its native name Rapa Nui), as the “before” condition prior to the opening of an international airport on the Island.
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Thank you for sharing. I knew there was a Canadian connection, but not all this rich history.
Without long term RCT trials, mainstream doctors are never going to script an “immunosuppression, transplant, anti-cancer” drug. Really bad optics, massive liability concerns without an FDA backing. No mainstream federal agency is deeming aging a “disease”.
And these trials will NEVER get funded for Rapamycin…off patent, no financial incentive for anyone connected to Pharma. Only a patented Rapalog “might” get a trial funded, but it’s a long way to prove median/total lifespan!!
DNA methylation, pheno-age, or some other intermediate primary end point trials might get realized when critical mass self-hacking AND medical community supports.
At least it looks like we might be starting with dogs…go MK!
Not holding my breath.
Another reason why this drug might be best adopted in Canada - where the legal industry is not so omnipresent as in the US. And, even in the US, you already have many doctors prescribing rapamycin for the past 5 years, with no significant issues…
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I don’t know anyone who has even heard of Rapamycin in my circles. My very supportive doc was like “wow, seriously, you want to take this”.
We follow the US when it comes to drug approval or emerging medical dogma…we are a rubber stamp. We don’t stick our necks out.
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Thats equally true down here in the US, even in San Francisco, except if you stray into the biotech communities.
How do you make topical from rapamycin? Would love to make some. Thanks for your formula.
Details on topical rapamycin here: Rapamycin for Hair Growth and Pigmentation, Skin Anti-aging
and here: DIY Rapamycin skin cream
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Do you have a formula for DIY Rapamycin cream/liquid for hair growth? Thanks so much!
Here is what one forum member is doing: Rapamycin for Hair Growth and Pigmentation, Skin Anti-aging - #26 by Agetron
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Yes, I am getting lots of new hair growth. It is slow because the new hairs are coming out of dormant hair follicles. Very fine and thin, but resilient. The new hairs are thickening my front and crown hair.
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@RapGuy . @RapAdmin , others!:
Do you have lab results with/without grapefruit?
Do you have lab results with generic pills/ pfizer pills?
What is the concentration we should aim? (The log graph presented at the top of the chat is a real mess). I guess the only useful part is after 24 hrs. Am I right to say that one should expect concentrations of 2ng/mL after 24 hours? (I’m following the line of 3 mg/m2. This because for my weight (72kg) and my height (179cm) gives an approximate superficial area of 1.9m2. Then 3mg/m2 equates to 6mg total for me.
Do you have the raw numbers of that graph for the first 24 hours? As I said, it is useful in the range 0-24hrs.
Many. many thanks! (I’m still looking for a GP that can prescribe me the lab tests in Perth Australia, this is another mess!)
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For full transparency, I work at Marek Health.
We offer low-margin self-service blood testing as part of our mission to reduce the barrier of entry to affordable health care.
Our Rapamycin (Sirolimus) serum blood test (LC/MS-MS) via LabCorp is only $59 vs $95 at LEF.
Additionally, the LEF “Chemistry Panel” (Lipids, CBC, CMP) is only $25 at Marek vs $35 at LEF.
Also, Marek Health offers the high sensitivity CRP test for $20 vs $42 at LEF.
And the IGF-1 test for $39 vs $75 at LEF.
You can find links to the aforementioned tests here: Rapamycin related blood tests - JustPaste.it
If this is against the rules here please delete my post. I stand to gain nothing, I am simply trying to help others get access to the same lab tests at lower costs.
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