San Francisco Bay Area Aging Meeting (BAAM), May 27th, 2025

[RapAdmin]

If you live in the San Francisco Bay Area and are deep into the biology of aging science (the meeting is PHDs and PostDocs presenting very technical papers on the biology of aging), I encourage you to attend this free biology of aging meeting… always some good information. Here is my report covering some of the presentations and posters at one of the last BAAM events: BAAM Presentations - GLYLO, and Meclizine mTORC1 Inhibitor

Dear BAAM participants,

We are excited to host the 25th Bay Area Aging Meeting (BAAM) at UCSF Mission Bay campus on Tuesday, May 27th, 2025. Registration is now open. Please mark your calendar and register at the link below if you plan to attend. Registration is free, but it helps us better plan for the meeting (especially for the meals). Please register as soon as you can!

Bay Area Aging Meeting

[Nick1]

I was kinda excited to attend till I realize they had picked a weekday as opposed to a weekend! Will see if I can shuffle stiff around.

[RapAdmin]

the program for this year

BAAM_UCSF_May27_2025_program.pdf (67.4 KB)

[RapAdmin]

I’m going to try to attend this meeting. Let me know if anyone else is planning to go and perhaps we can meet up.

[Beth]

Bumping so I can stop looking at the mice

[RapAdmin]

I caught the second half of the day of presentations at BAAM. Here are some of the posters I found interesting…

A new MTORC1 inhibitor company that some guys working to get funding on. Contact Greg Timblin if you want to help finance their efforts:

[RapAdmin]

Some short parts of the presentations I found interesting:

Some researchers at the buck are studying how to measure mitophagy and are getting some really good measures. I’d love to see this in the clinic…

And they are looking at, and measuring, mitophagy activators. And it seems mitophagy can be activated via a number of different mechanisms…

And out of Stanford, how sex impacts aging (TLDR: at least in Killifish, it’s good !)

Mating leads to “Young” hepatocytes in Old Females

So, mating lowers inflammation. They suspect it’s due to hormonal fluctuations caused by mating.

In other good news, exercise seems to rejuvenate intestinal stem cells:

I spoke with the presenter, and while there is research suggesting the same effect with rapamycin, they have not yet done a head to head comparison (which I suggested would be a good area to study).

[Greg_Timblin_Inapill]

It was great meeting you, and thank you for bringing attention to our work on making novel, immune-selective mTORC1 inhibitors at Inapill! -Greg Timblin (greg@inapill.com)

For anyone interested in helping us drug this biology to make vastly improved treatments for inflammatory & autoimmune diseases (i.e. let’s replace Humira), and improve healthspan by targeting chronic inflammation, please reach out!: A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan | Nature Aging

[RapAdmin]

Greg, thanks for dropping by, and hope you continue to participate here. We are very supporting of new longevity companies here, so please keep us up to date on your progress and let us know if we might be able to help. I think your company is really interesting.

For others here, Greg is a recent UC Berkeley PHD / UCSF PostDoc who is venturing out with this new business. I encourage this type of entrepreneurship as it can really move the field forward.

I’d love to see your drug (the first one you’ve identified and mentioned yesterday) submitted to be part of the Interventions Testing Program this year to see how it does in longevity. https://www.nia.nih.gov/research/dab/interventions-testing-program-itp

I hope you, or perhaps a grad student you know who has a little extra time, can manage to submit an application for next year. We have some example applications here: Feb. 28th Cutoff For NIA ITP Aging Drug Submissions - Ideas for New Testing?

and: Feedback from ITP on Compound Proposal