It looks interesting and seems to have potential based on the few studies done (and mostly sponsored by the company I think)… the counterweights are that not much in the way of 3rd party validation testing, so with a reasonable amount of skepticism I’d say its too early to tell one way or another… and its really expensive.
I agree with Rapadmin. Urolithin sounds interesting, but the cost and the lack of research put it in the “pass” bucket for me. There are a lot of other supplements which are less expensive and more effective… Such as Rapa and Acarbose.
They only have 3rd party tested the NMN and Resveratrol I believe, at least thats what they show. I prefer others like Lifeextention or NOW, they pretty much 3rd party test all of their hundreds of supplements and they manufacture in the US, some of their compounds might come from China, but they have their own labs that check qualities. And they give their products freely to ConsumerLab for comparison tests.
I believe that if one has Akermansia in the microbiome then eating pomegranate allows it to produce your own Urolithin A
Probably worth finding out which strain of Akermansia it is and testing to see if you have it.
I imagine that if one’s diet is high enough in precursor tannins, eventually metabolizers will be selected for. Given that the precursors can be obtained from not too expensive, nutritious foods maybe that would maximize cost/benefit.
Unfortunately, we may need the actual urolithin A supplement to get the benefits as only ~40% of us can convert berries, nuts, etc into urolithin A and this also decreases with age. How are we to know if we are among the fortunate 40%? Reduced C-reactive protein is the biomarker mentioned in several articles, but CRP is an unreliable marker IMO because there are just too many factors that affect CRP on a daily basis.
The other unfortunate thing is that even though are still a few urolithin A supplements on Amazon, including Mitopure. They are quite expensive. Some studies use doses of 1gm/day Which makes the daily cost of the supplement at $4+/day. Other studies found improved results with 500mg/day which at Amazon prices makes it $2.33/day which still makes it an expensive supplement.
This article is fairly recent, July 2021, and disputes other articles I have read that claim that gut bacteria Gordonibacter urolithinfaciens is required to convert ellagic acid-containing foods to urolithin A. Incidentally I cannot find any probiotic supplements that contain Gordonibacter urolithinfaciens. Even if I could find such a probiotic it would have to be taken daily according to studies I have read,
Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts.
“Urolithin A (UA) is a gut microbiome-derived natural compound that only 40% of people can naturally convert from dietary precursors at meaningful levels.”
Unfortunately, we may need the actual urolithin A supplement to get the benefits as only ~40% of us can convert berries, nuts, etc into urolithin A and this also decreases with age.
Acutely, yes. But there’s no suggestion here that the relevant organisms aren’t present through out the population, just in variable quantities. So why shouldn’t feeding them make them more populous? Testing this wouldn’t be too hard, but as far as I can tell no one has.
It turns out proanthocyanidin-rich foods cause a bloom. Here they tested blueberries, cranberries, grapes and a control:
The figures are all at the bottom. I feel like they kinda missed the most exciting proanthocyanidin rich food of all: Aronia Berries.
I wish I was competent enough to upload the table comparing aronia to blackberry, strawberry, and raspberry. Aronia was 4300, next closest was blackberry at 1100, then the other 2 were around 200. You gotta love it. The answer is not to eat the bacteria, it’s to eat Aronia and yellow raspberries.
Actually, Amazentis did provide testing for a while as part of a trial… I got their package for the blood tests but got busy and didn’t sent it in (so don’t know my results). But yes, testing for something like this seems really cheap. See here: Urolithin A - Virtual Clinical Trial by Timeline Nutrition
I like Aronia juice, it’s good and not too expensive. Generally speaking I distrust expensive “super” foods – marketing tends to overestimate the benefits.
As speculation, one might propose that what’s happening is not only that relevant polyphenols directly feed bacteria, but also that they stimulate and modify mucus secretion, which further feeds them. Perhaps elderly folks have a reduced mucus response, making things harder?
Further speculation: small amounts of oak leaves (which are free!) should improve gut health and increase UA production for not-too-old people eating a “modern American” diet. Note that too much tannin is toxic, however. I don’t know how many tests would be required to be sure if this works on any one person, but somewhere a PhD student is looking for a project.
In studies investigating45
polyphenol supplementation in mice, administration of isolated PACs at levels representing 1% of the diet46
by weight was shown to increase the relative abundance of A. muciniphila from <2% to >40% within days
So within days of consuming dried blueberries (inferior by far to aronia) A. Muciniphila go from less than 2% to more than 40%. Doesn’t even seem possible. This is a massive bloom. Doesn’t seem healthy even.
I’m slowly working my way through a stash of frozen aronia berries a couple hands full per day, they are bitter and now I know why.