Also desert shores, did you this medicine have any impact on your weight? I read where this med could cause weight gain. Thanks
I am not currently taking trazodone, but when I did I took 50mg ~1/2hr before sleep. This shortens the time it takes you to go to sleep. More than 50mg is not required IMO.
Since I have been taking rapamycin my weight has been quite steady. The trazodone had no effect my weight.
Thanks for the info. May I ask why you stopped? Just trying to determine if I want to start taking this.
I am 45 and I always have difficulty sleeping more than 6.5 hours per night on average. But for several nights after a dose of Rapamycin, I can’t sleep more than 5 hours a night. It’s brutal.
I was taking 6mg weekly, stopped. Now my plan is to work my way up to 6mg every 9-10 days. However, on Monday morning I took only 1mg and I haven’t had a good night’s sleep for three nights. With sleep issues though, you never know the real cause.
Also when I took 6mg/week I had aphthous ulcers a few times, zits, and even a zit or something in my ear canal that was very unpleasant. I’m starting to wonder if it’s worth it.
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It tells me that the dose is too big and interval is too short for you.
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Wow - thats a really extreme reaction. Is it possible that something you are eating, supplementing with, or drinking, is increasing the bioavailability?
Have you reviewed this thread? Rapamycin Interactions with Other Food, Drinks, Supplements and Drugs
I’ve had more trouble sleeping when doing “extended” fasts, than when on rapamycin. My extended fasts are not that long, they usually last 36-40 hours.
I don’t think there are any drug or supplement interactions, but it is very likely that my sleep issues are related to stress, grief and other factors. But when I was taking 6mg it did feel like there was a correlation between the dose and a few difficult nights.
I put a link in another thread to the idea that autophagy interferes with circadian proteins. Hence when rapa is doing its job of encouraging autophagy it is likely to cause difficulties with sleep.
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What surprised me is that those who take Rapamycin often blame any diviation from “normal” on Rapamycin without taking into consideration very many other molecules that they ingest every day. Each new pimple or rash, headache or insomnia, leg cramps, etc. , all blamed on Rapamycin. Millions of people suffer from insomnia and they are not on Rapamycin. We need to keep in mind that the right dose, which is very individual, is the key. The right dose is the dose that does not produce negative side effects. Rapa is not one size fits all. I do not have negative side effects if I take the right (for me) dose.
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Out of curiosity I just checked my sleep log the night of my last rapa dose, estimated at 30mg. My sleep score was evaluated as “optimal” by my Oura app, and was much better than my normal sleep score.
Of course that doesnt mean anything more than for me rapa doesnt seem to interfere with sleep.
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For me, Rapa also doesn’t interfere with sleep. I take 3 mg Melatonin and sleep between 7-8 hours.
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Wow - so what time of the day did you take the 30mg (or equivalent)? And your sleep measure was just as good or better than the previous days when you had not taken rapamycin - is that right?
Please post a summary graph of the week if you can…
“Wow - so what time of the day did you take the 30mg (or equivalent)? And your sleep measure was just as good or better than the previous days when you had not taken rapamycin - is that right?
Please post a summary graph of the week if you can…”
I took my tri-weekly rapamycin on Sunday morning 3/5.
Sorry, but I dont know how to send a graph from the Oura app. Here is an excel spreadsheet for the week before my rapa dose.
You can see that my sleep quality in general isnt what it should be. …I’ve been trying to increase my deep sleep.
At least the rapa doesnt have a negative effect.
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@CTStan have you noticed a change in your deep sleep duration as a result of the new Oura ring algorithm?
As a side note, I just screenshot the graphs from my Oura Ring, then save them as a pic before uploading here.
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I started on biohacking with the objective of improving my sleep. I use a fitbit as a tracker and did also use the E500. I found that fitbit does not pick up short naps say of a duration under 30 mins. The E500 sometimes did. I also have used Muse EEG which is really good at picking up sleep, but a real nuisance to wear (or moreso to keep on your head when sleeping).
I am of the view that one thing that happens during sleep is that the pineal gland provides neurons with a higher level of melatonin than is provided to the rest of the body (via the Third Ventrical of the cerebro spinal fluid). Hence I think that one good thing about a high serum melatonin is that it assist the brain in coping with less sleep.
However, my key functional test for sleep is whether I can work at a high performance level for the next day and particularly without having any need for a nap at around 2pm. If I don’t sleep well then I can cope without a nap, but it is a useful thing for cognitive function in the afternoon.
I would not say I have resolved my insomnia (which is mainly a sleep maintenance issue rather than a sleep latency issue), but often I sleep sufficiently to enable me to be fully functional the next day without a nap (such as today).
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Are there papers on this? My experience with rapamycin has been… bad. I’ve been searching for information that might suggest that some people are hypersensitive but haven’t found much.
Based on my experience I can’t imagine taking more than 1mg per week, and yet most people take at least five times that.
I got my sirolimus from a big US pharmacy, but I’m going to look around here for a pill identification thread.
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Not that I can tell.
I havent controlled the variables, so the confounding influence of afternoon coffee, late dinner, various supplements, makes any effects hard to determine.
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I don’t think there’s any research re cons and pros of individual dosing yet. We are still at a very early stage of using Rapa. I’m very sensitive to medications in general, including Rapa, and usually need a much smaller dose than many people do. After trying different protocols, I came to a conclusion that it’s important for me to keep not less than 12 days, but ideally more, between doses. If I do that, I don’t have negative side effects. My primary goal is to support my transplanted kidney, so my experience may not work for those who take Rapa only for longevity.
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I am curious why you say that your sleep quality isn’t what it should be. I believe they give you a little crown at a score of 85. My question is whether Oura provides a valid sleep analysis. I have been using the ring for just about a year now. I also purchased a
Fit bit at the same time as the Oura ring. What I know for sure is that data from the Oura and the Fitbit are not significantly related. I have graphs of the data for sleep quality, sleep time, deep sleep time, hrv, calories burned, etc. Except for sleep time, the R^2 correlation for all these are less than .05. Sleep time correlates better at about .65. Has anyone else conducted a similar analysis. I know that many times the sleep score from Oura does not mesh with how I feel.