Rapamycin and risk of cardiovascular disease

[AnUser]

Yes it is related to bempedoic acid and not ezetimibe.

[Neo]

Thank you @AnUser (extra characters)

[SouthHill]

@John_Hemming

The normal reason why ACLY does not produce enough Acetyl-CoA is a shortage of citrate not a shortage of ACLY. However, if you are setting out to reduce Acetyl-CoA production then that will impact on ac-CoA availability.

How does one best increase citrate intake - perhaps by taking potassium or magnesium citrate?

[Virilius]

It appears bempedoic acid is better suited as an adjuntive therapy to statins similar to ezetimibe.

[Virilius]

I take a high dose magnesium citrate and a low dose potassium citrate every day. Potassium is hard on the kidneys so better keep that dose low.

[John_Hemming]

I wrote about it here:

Question as to what to do with my protocol

Warning: There may be unidentified risks in trying parts of this protocol. Anyone who tries part of the protocol needs to monitor their biomarkers and if any harm is being caused stop using it. No medical advice is being given people need to do their own calculations and assessments and take medical advice from a healthcare professional where appropriate. People take their own decisions at their own risk. Get a baseline. Before doing anything it really is worth having a baseline. This really has to include high sensitivity CRP. There are costs to testing and the costs of testing probably exceed the costs of the protocol. A baseline test before starting anything is really helpful. The principle The principle behind this protocol is that if you improve how cells work then you improve how the body works. Cells function by generating energy and producing proteins. If a cell is unable to produce the full range of proteins then it will not function properly. The theory underp…

It is quite complex because if you want to get it right you need to take a few grams every half hour or hour or somewhere in between.

I tend to want to finish with citrate by 3pm at the latest.

[Radiata]

I just purchased some of the Bempadoic + Eztamibe combo drug and wasn’t able to get a price back from Guru Baba though they appeared to have the lowest price upon searching. A few other companies had it for about 40 cents a pill before shipping. Nilkanth had the Zydus version, so I went with that. Also bought some 5 mg Rosuvastatin for like 5 cents a pill.

[AnUser]

The 50-500 rupees price range for a strip of 10 makes me think it is unlikely they are really selling it for 50.

[SNK]

@Radiata

Bempadoic + Eztamibe

Ran into couple studies that suggest that statins help with telomere length, hence slow down aging. I have normal cholesterol, but would any of you guys think taking a statin might be a good idea for anti aging? Plus is anyone (with normal cholesterol levels) in these boards taking statins?

[Virilius]

I had LDL in the low 110s prior to starting my rosuvastatin/ezetimibe combo. Now I’m in the mid-50s. Other than some muscle-related sides that resolved upon starting ubiquinol and “brain fog” which resolved on its own, I had no major issues.
Keeping your apoB low is extremely important in us humans as it’s the biggest killer in the Western world. The off target effects of statins such as reduced inflammation, possible reduction in dementia rates etc. may also be beneficial for health.

[Radiata]

What is “normal”? I think a lot of people here are shooting for “optimal” wherein LDL-C/apoB are low enough to preclude ASCVD. For me, my LDL-C ranges from about 58-70 mg/dl and I hope to reduce it into the 30-40 mg/dl range (apoB and LDL-C are pretty close in this range from my tests). I’ll try the B+E combo to see how far that gets me, and then possibly add a statin later.

Also, could you post the telomere studies?

[SNK]

wow thanks, this is totally new to me. I literally thought of statins as being big no no unless you are prescribed them by a doc. So that I understand this correctly (I’m a bit new to this anti-aging thing) using statins helps lower ApoB right? I think i can live with side effects as I know couple people (one of them my uncle) who have been using statins (cholesterol issues) for last 25 years (now at 95) with no major adverse effects.

[Virilius]

I literally thought of statins as being big no no unless you are prescribed them by a doc.

While it is generally a good idea to have a doctor monitor your blood markers when using a statin, research has shown that modern statins are very safe, particulary the water-soluble ones such as rosuvastatin. They significantly lower all cause mortality and the effect becomes larger the longer you use it.

@SNK

So that I understand this correctly (I’m a bit new to this anti-aging thing) using statins helps lower ApoB right?

Correct, it lowers apoB (and cRPC (marker of inflammation)).

[SNK]

@Radiata

I’ll try the B+E combo

Pardon my ignorance what is B+E?

[Radiata]

Bempadoic acid + ezetimibe, most commonly 180 mg bempadoic acid and 10 mg ezetimibe, which is based on clinical trial data. Brand name “Nexlizet” but widely available as a generic from India.

[SNK]

@Virilius

They significantly lower all cause mortality and the effect becomes larger the longer you use it.

It is all making sense now. My uncle was always sick (major heart problems, on top of high cholesterol) and no one expected him to live this long. And all he takes is jut Statins (don’t know which one).

[SNK]

@Radiata

Bempadoic acid + ezetimibe, most commonly 180 mg bempadoic acid and 10 mg ezetimibe, which is based on clinical trial data. Brand name “Nexlizet” but widely available as a generic from India.

Any reason why you’d prefer B+E as opposed to statins? Or supposedly fewer side effects?

[AnUser]

@DeStrider how is ezetimibe working for you? What dose are you taking?
I am starting with 10 mg a day now, taking no statin, might add it later if I don’t find any other medicine like bempedoic acid.

[Virilius]

I wouldn’t expect an LDL reduction of more than 30-35% with the B+E combo.

[Neo]

@AnUser

ezetimibe working for you? What dose are you taking?
I am starting with 10 mg a day now, taking no statin,

Were you also taking a PCSK9i?

What do you think the optimal adjunct thereby for someone on PCSK9i who is still not low enough vs aggressive Apo B targets? (In my case I also have genetically elevated Lp(a). I was thinking of adding ezetimibe.