I just purchased some of the Bempadoic + Eztamibe combo drug and wasn’t able to get a price back from Guru Baba though they appeared to have the lowest price upon searching. A few other companies had it for about 40 cents a pill before shipping. Nilkanth had the Zydus version, so I went with that. Also bought some 5 mg Rosuvastatin for like 5 cents a pill.
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The 50-500 rupees price range for a strip of 10 makes me think it is unlikely they are really selling it for 50.
Ran into couple studies that suggest that statins help with telomere length, hence slow down aging. I have normal cholesterol, but would any of you guys think taking a statin might be a good idea for anti aging? Plus is anyone (with normal cholesterol levels) in these boards taking statins?
I had LDL in the low 110s prior to starting my rosuvastatin/ezetimibe combo. Now I’m in the mid-50s. Other than some muscle-related sides that resolved upon starting ubiquinol and “brain fog” which resolved on its own, I had no major issues.
Keeping your apoB low is extremely important in us humans as it’s the biggest killer in the Western world. The off target effects of statins such as reduced inflammation, possible reduction in dementia rates etc. may also be beneficial for health.
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What is “normal”? I think a lot of people here are shooting for “optimal” wherein LDL-C/apoB are low enough to preclude ASCVD. For me, my LDL-C ranges from about 58-70 mg/dl and I hope to reduce it into the 30-40 mg/dl range (apoB and LDL-C are pretty close in this range from my tests). I’ll try the B+E combo to see how far that gets me, and then possibly add a statin later.
Also, could you post the telomere studies?
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wow thanks, this is totally new to me. I literally thought of statins as being big no no unless you are prescribed them by a doc. So that I understand this correctly (I’m a bit new to this anti-aging thing) using statins helps lower ApoB right? I think i can live with side effects as I know couple people (one of them my uncle) who have been using statins (cholesterol issues) for last 25 years (now at 95) with no major adverse effects.
I literally thought of statins as being big no no unless you are prescribed them by a doc.
While it is generally a good idea to have a doctor monitor your blood markers when using a statin, research has shown that modern statins are very safe, particulary the water-soluble ones such as rosuvastatin. They significantly lower all cause mortality and the effect becomes larger the longer you use it.
Correct, it lowers apoB (and cRPC (marker of inflammation)).
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Pardon my ignorance what is B+E?
Bempadoic acid + ezetimibe, most commonly 180 mg bempadoic acid and 10 mg ezetimibe, which is based on clinical trial data. Brand name “Nexlizet” but widely available as a generic from India.
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It is all making sense now. My uncle was always sick (major heart problems, on top of high cholesterol) and no one expected him to live this long. And all he takes is jut Statins (don’t know which one).
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Any reason why you’d prefer B+E as opposed to statins? Or supposedly fewer side effects?
@DeStrider how is ezetimibe working for you? What dose are you taking?
I am starting with 10 mg a day now, taking no statin, might add it later if I don’t find any other medicine like bempedoic acid.
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I wouldn’t expect an LDL reduction of more than 30-35% with the B+E combo.
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Were you also taking a PCSK9i?
What do you think the optimal adjunct thereby for someone on PCSK9i who is still not low enough vs aggressive Apo B targets? (In my case I also have genetically elevated Lp(a). I was thinking of adding ezetimibe.
Yes supposedly less muscle pain side effects commonly reported with statins. Then again, there are many others
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No but I am thinking about adding a PCSK9 inhibitor.
I would say ezetimibe + bempedoic acid, also a fibrate could be interesting as well
Ok, thanks. Happy with the PCS9i as my base med, including for what looks like a very good safety profile (and I experience no side effects) and because it helps lower my Lp(a)by around a third, but may research the fibrates in the future.
Bempedoic 1.3% -prostatomegaly reported vs 0.1% placebo. That is no joke. Too scary for me. Would have considered if it was maybe double the placebo, but not 10 times higher. I’ll probably give Rosuvastatin at small doses a try and see how it goes.
Here are the changes I noted in my relevant blood markers after a few months of ezetimibe 10mg.
| goal | 7/5/23 | 10/16/23 | |
|---|---|---|---|
| APO B | <70 | 87 | 77 |
| LDL | <70 | 98 | 83 |
| HDL | >60 | 60 | 67 |
| Total Cholesterol | <160 | 169 | 162 |
| Triglycerides | <70 | 48 | 57 |
| Tg/HDL | <1 | .8 | .85 |
The results showed positive effects and no side effects, but I havent reached my goals yet. Will continue with 10mg
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I accidentally pinged you when I meant @DeStrider always mix you two together since it’s both a purple C 
But yeah you both had negative effects from statins, interesting to hear you’re using ezetimibe as well.