Thanks! Even i miss many posts and threads.
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The effects are very mild, a 1 to 3 mmHg SBP: Canagliflozin - Another Top Longevity Drug - #1938 by adssx
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@RapAdmin a while back you posted about a new blood pressure product that also did something like pulse wave velocity? A bit more than that even. I can’t find it under blood pressure, or anything else actually. What was that thing? I need a new BP cuff anyway.
I’m not sure what you’re referencing… I did find the new whoop product with some blood pressure tracking abilities interesting: The Everything Technology and Longevity Thread - #94 by RapAdmin
I would look through the “Everything Technology and Longevity Thread” - here is a ring doing blood pressure monitoring: The Everything Technology and Longevity Thread - #89 by RapAdmin
Found it:
Arterial health assessment or some such…Cl-User explains it somewhat and shows that it doesn’t really work. Thanks anyway!
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That article mentions losartan as reversing damage in mice. Here’s another comparison between losartan and telmisartan:
PAPER FROM INDIA 
Blood pressure-lowering effect of telmisartan compared to losartan among mild to moderate essential hypertensive adult subjects: A meta-analysis
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When I went to the hospital back in September they prescribed me Amlodipine (tiny little flat pills). My blood pressure fell to where a few times it was 110 over 68 or so (they prescribed it I think to prevent complications in the brain). That’s pretty good! Usually my bp is around 125 over 80 or a little more.
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One thing that has occurred to me is how people talk about bp. They talk about it like people are being lazy or lacking in morals or something if it’s like 140 over 85 or so. In many cases, that might be the median BP in some parts of the world, or at least the upper third of the population. Who’s to say that isn’t the typical BP of our ancient ancestors that made it to that age?
What I’m getting at is that there’s a kind normative language about the right bp level. I think the more ethical way to talk about bp is that medicines are artificially keeping it low. What we’re doing is more akin to applying life-extension methods than being an upright, decent human being.
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Untreated, my blood pressure is low. Every time I’ve tried a -flozin it has given me a headache and made me feel light headed and out of it for 1-2 days.
I’ve tried eating extra salt and drinking lots of water, but haven’t found a solution, so no -flozins for me.
Hunter gatherers had/have a diet low in salt and high in potassium, they were physically very active and lean. Their BP was most likely low.
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I was familiar with only the Yanomami but here’s a review of other hunter-gatherers in South/Central America, all had 95/65 BP with hypertension (>140) at 0-2% prevalence.
African hunter-gatherers data ~120/80 hypertension 0-2% (Hadza higher with age):
Asian fish-hunter-gatherers:
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Those are interesting numbers, though according to this:
According to statistics, more than 75% of adults over 65 have high blood pressure.
Adults between the ages of 55-64 are also at-risk, with 70 percent of men and 63 percent of women meeting the standard.
Here, “high blood pressure” means:
A normal blood pressure is lower than 120/80. Once your blood pressure reaches 130/80 or higher, you meet the definition of high blood pressure.
Why does blood pressure rise like that with age?:
This happens because our arteries, which carry blood from our hearts, change over time. They become stiffer, which can result in higher blood pressure.
So, do hunter gatherers not experience this? I’d guess that they do. It’s possible the ones who would have pushed the stats higher died young, so didn’t get counted. And the ones that lived to age 65, say, were exceptionally hardy (able to battle germs and bacteria and other things that tend to kill others in their tribe).
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If it’s because of survivorship bias, wouldn’t there should be a spike in BP with age, as it takes time for it to cause damage, especially without other risk factors? An inverted U-shape curve.
If that’s the case, is the age related data in the tables and another one from Yanomami in the paper showing it’s stable and without bias?
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Maybe so. It’s just a little hard to believe that the lifestyle and diet of hunter gatherers could delay the rise in blood pressure that we see in the U.S. – the percentages of Americans with much higher blood pressure just seem too high. And for even older Americans (like age 80+), targets for bp are like 150 over 90. Could that really all just be due to the cumulative effect of not adopting a hunter gather lifestyle?
One thing about the “normative language” I wrote earlier that didn’t occur to me was that a lot of the talk about keeping the numbers so low (like 110 and lower) is likely mainly directed at people under about the age of 55, or even 50. Once one is past an age like that the targets and standards shift.
I’m open to the possibility that the data is biased, or wrong in some other way.
If this was a cohort study, rather than a cross sectional one, should resolve the bias question, if my memory serves me correctly. At the same time it seems odd that the people with hypertension would die, or is that not the implication?
@relaxedmeatball is there any consensus about whether age related increases in hypertension is because of lifestyle (salt, adiposity , activity levels) or aging? If the latter, what’s the consensus related to hunter-gatherer data on HBP levels with age?
https://jamanetwork.com/journals/jamacardiology/fullarticle/2713959
An updated optimal BP level and medication level survey:
What are the optimal BP level that you are currently aiming, with what medications at what dose and why? Everyone please chime in.
Additionally, some Pulse Pressure Info:
My BP meds is telmisartan of 80mg. Sometimes I add 5mg Amlodipine.
My BP is usually around 110/70. Sometimes lower but no dizziness with it.
Peter Diamandis is on Losartan.
Brian Johnson is on Candesartan 8 mg. It is equivalent of 50 mg Losartan and 40 mg Telmisartan (need fact checked).
Longevity experts and biohackers target optimal blood pressure around 110-120 systolic / 70-80 diastolic mmHg (or lower if tolerated), viewing standard “normal” ranges (120-129 systolic) as suboptimal for maximizing lifespan.
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Peter Attia (longevity physician): Recommends targeting <120/80 mmHg (often <120 systolic, without symptoms like lightheadedness), based on the SPRINT trial showing major reductions in CVD, stroke, and mortality risk.
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Bryan Johnson (Blueprint protocol): Personally achieves exceptionally low BP (brachial ~114/76 mmHg previously reported; recent biomarkers place it lower than 90% of 18-year-olds), using therapeutics like candesartan for cardiovascular protection equivalent to a much younger age.
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Valter Longo (fasting researcher): Observes fasting-mimicking diets can substantially lower systolic BP (e.g., drops of 4-20 mmHg in studies, such as from 140 to 120 mmHg in clinical cases), supporting periodic cycles for reduced cardiovascular risk factors.
Supported by longevity studies (e.g., SPRINT extensions) showing lowest CVD/mortality risk below 120 systolic, with benefits extending lifespan.
Here is confirmed report on BJ
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A large study in rural China published in Nature Medicine showed that blood pressure below 130/80 mm Hg (millimeters of mercury) not only lowered the risk of dementia, but also reduced cognitive impairment by 16%. High blood pressure, also known as hypertension, can damage small blood vessels in the brain, and is associated with cognitive decline and memory problems. This study is the first to definitively show that lowering blood pressure to these levels can truly decrease the likelihood of dementia.
This, says Christopher Howes, MD, a Yale Medicine cardiologist, is important not only because high blood pressure is associated with many other health conditions, but because there are few proven ways to reduce the risk of dementia.
“We have some medicines that can maybe slow down the progression of Alzheimer’s disease, but we don’t have many ways to prevent dementia,” he says. “Now we have this real objective data that shows people who had high blood pressure and were on therapy for it have a lessened likelihood of dementia.”
Plus, high blood pressure is an important risk factor for coronary artery disease, Dr. Howes adds. “Treating high blood pressure and elevated cholesterol levels are two cornerstones to cardiovascular health, he says. “We have effective medications for both conditions. We need to work aggressively with our patients to achieve the desired target levels.”
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The only device I know of that has clinical validation of PWV measurement are the Withing scales. Been tracking mine for 5 years now. Mine is lower than 80% of people in my age group using this scale and it has been continually improving for the past 3 years. That’s the time frame of my addition of manganese to my Vit stack. BUT there is a confounder as I started GLP1’s 2 years ago and lost 55lb, which probably provides a stronger effect. But who knows, there may be a synergy?
Look up manganese, it may help to reduce arterial plaque Just do not over do it as it has an Inverted U-shaped dose–response : Outcome improves as dose rises up to a peak, then worsens as the dose increases further and with manganese it can become harmful at higher doses.
Also I’ve been keeping my BP around 100/65 for the past year and no dizziness.
clinical validation of PWV measurement are the Wit (1).pdf (346.6 KB)
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