Its an interesting area… but I also think there needs to be some more data to make sure that the mouse data translates to benefits for humans.
I’ve been in this clinical trial for plasmapheresis (TPE) from this San Francisco-based startup, but I’ve not heard anything back from them over the past 5 months… they had said they’d be inviting me back for followup blood draws and testing, but they have not contacted me, and when I contacted them they said “later…” Plasmapheresis Startup Looking for Clinical Trial Participants SF Bay Area
Also - as you may have heard, Bryan Johnson has been trying Young Blood plasma using his son’s blood, and other’s at a clinic near Dallas. But - he said they had no good / positive results with it, so now he’s stopping it.
So - I still think the data needs further human validation right now.
the problem really isn’t expertise; with such an old and common practice, expertise is plentiful. the main obstacle is convincing them to go around the rules and offer it off-label for a sane price (instead of being available only to the super-rich).
If anything, Bryan’s results validate precisely what we already know about this “young plasma” nonsense. But no point repeating myself – life is too short lol.
I do not feel you supported that statement. Further up in this chain there is support for young blood / young / young plasma blood factors potentially having meaningful impact. How come you feel that it is irrelevant - logistics? Or are you saying that it scientifically is not a meaningful hypothesis (whether complementary to plasmapheresis or the main driver of a lot of the heterochronic parsnips results - I’m personally not saying that plasmapheresis is not helpful)
I have read the entire thread and am ready to move forward and get this started. I will buy the plasmapheresis equipment and set up a clinic. People may come to the clinic and use the equipment cheaply.
The main issue is where to establish this clinic. I think a major city in Texas might be best for the first clinic. Because I plan to sometimes replace my plasma with just saline and albumin as shown by the Conboys, but other times I might want to replace my plasma with young plasma which for older people I speculate is possibly better. Texas is the only state in the country where I know how to get young plasma so I would like to be there.
If I start such a clinic in Texas do you think that will be useful to people such as the members of this group or is that too far away from where people live?
As we know, there are some clinics in this segment in Texas but overly priced! Therefore, i think if someone establish w/ low price and good/safe equipment “costumers” showed up. Iam one of them.
Plasmapheresis alone is promising and as we learn more, we may find that its effectiveness is enhanced when used with other interventions. The one I’m thinking about now is E5, whenever it finally gets into human trials.
In rat trials, the exosomes that constitute E5 have to exceed the old rat’s natural exosomes by four to one to get its dramatic effect. Manufacturing enough volume seems to be a hurdle Harold and Akshay are trying to get over. What if the old exosomes in the plasma were removed by plasmapheresis first? Maybe much less E5 would be needed.
If your planned plasmapheresis center were located in a city where aging/longevity research is already being pursued in a major way, future collaborations could be in the picture. Houston has a big medical center, but I’m not sure if any aging research is done there. I’ve never heard much about Dallas or Ft.Worth as medical centers. I’m pretty sure there’s not much of that going on in Austin. San Antonio has the Barshop Institute and the UT Health Science Center, with the associated San Antonio VA Medical Center that all research aging/longevity and run clinical trials.
Good to here others are on the same page, I was thinking about buying the machine and doing it in flordia, but Texas is good. Please count me and 2 friends in.
@Lankheet1@davidjhp if you really want to make a positive impact to the community, please, please share with us advice for how to procure the equipment (particularly without a licence) and any other practical information.
But, generally, I did not notice any benefits from this treatment process. If anything I actually felt worse during the 4 month period and few months afterwards. I had paused my rapamycin a month prior to the clinical trial, and I have to say that I think the benefits / results I’ve noticed from 3 years of rapamycin far exceeded anything I’ve noticed from a series of 6 plasmapheresis / TPE treatments. I’ve been saying for the past year that I thought I was in the “control” group that didn’t get any actual treatments… but just recently found out that in fact I did get the treatments.
And the results were actually extremely disappointing for me. I had read all the research and have been very, very hopeful about plasmapheresis. If anything, my strong bias towards the TPE type therapy would seem to suggest that I’d at least get a strong placebo benefit.
So - I await more research on this topic. I hope that the Kiprov / Buck Institute / startup collaboration in the clinical study I participated in, results in a paper that demonstrates some significant effect size. Perhaps it provides benefits that you don’t feel. I really hope this works, but right now I’m not yet convinced.
please share with us advice for how to procure the equipment
My preference is the Fresenius Kabi Amicus Separator. I am still researching the options. If there are any problems trying to buy it without a license then you have to find a doctor to buy it for you.
Thanks, your words of encouragement mean a lot to me.
please keep me posted.
I changed my mind about Texas, because I find the laws there too hard to deal with so I will not move to Texas. I am currently planning to move to Florida soon to set this up. I am currently leaning toward Tampa FL but still studying the location options.
We have capital available to help underwrite the venture
This could help a lot, please contact me at david10@davidjpotter.com and let me know a little more about your thoughts on this.
Dr. Kiprov’s latest lecture and the preliminary results of the plasmapheresis clinical trial for aging, which was presented at the A4M Longevity Fest last week in Las Vegas.
I was in group A or B (they haven’t told me which one).
It seems that plasmapheresis may do something beneficial for people. The key issue in terms of cost justification will be how long the benefits last, and how frequently it needs to be done to maintain the benefits.
I don’t know right now. Will go in for full blood test suite this coming week. My data will be confounded because I restarted statins just before the clinical study…
@davidjhp , I applaud your effort. I will travel to Florida, Texas or wherever for a more reasonably priced TPE. No big money left for me after four of those treatments at Kiprov’s clinic.
I met with the Conboys at Berkeley, who thought that a second TPE just two days after the first is of questionable benefit. So I cancelled my treatment nr 2 of that round scheduled for next day, upsetting them all. Got that TPE recently a year later, instead. Too seldom to have an effect?
I have poured over those blue- and redcolored protein markers from the original six-person trial but it’s hard to get a real handle on the magnitude of the benefits of the procedure. In particular, as rapadmin notes, on how long benefits last. Hopefully there will be some independent review of the recent trial.
In any case, a decent price allowing more frequent treatments would be a huge boost.
Ulf - I’m curious, did you get a discount on the 4 treatments? I think the normal price at Kiprov’s clinics is around $6,000 per treatment, is that correct?
