Imeglimin. A new and novel drug thats better than Metformin

[desertshores]

What was your metformin dose? If you were taking 1,000 mg of Imeglimin twice daily, that is comparable to taking 500 mg of metformin twice daily. At that dose equivalent I didn’t find that Imeglimin worked as well as metformin.

[cl-user]

@desertshores

If you were taking 1,000 mg of Imeglimin twice daily, that is comparable to taking 500 mg of metformin twice daily. At that dose equivalent I didn’t find that Imeglimin worked as well as metformin.

1000mg BID is not enough for the western population. I just posted about that here: Imeglimin: An Approved Diabetes Pill Just Made Old Mice Stronger - #14 by cl-user

[Davin8r]

@cl-user

Erythrocyte lifespan was significantly prolonged in both the 1–3 month and 4–6 month periods.

Wouldn’t this cause elevated hemoglobin and hematocrit?

[Kebossit]

Ya, 1g Imeglimin 2x daily vs 1 gram Metformin once daily.

[Kawaii]

@Davin8r

Wouldn’t this cause elevated hemoglobin and hematocrit?

Across the dosing period,RBC count, hemoglobin, and hematocrit all drop.

[Davin8r]

@Kawaii

Across the dosing period,RBC count, hemoglobin, and hematocrit all drop.

This appears to be non-significant in either direction due to homeostatic mechanisms kicking in.