Thank Curt for your detailed info. I’m assuming you are cutting imeglimin pills in 1/2 to get the 500mg, or you can order 500mg also? In other words, is it ok to cut the pills, are they coated etc…
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1000x2 daily is the only correct dose recommended.
It does not work as well as metformin for fasting glucose. However it seems as good or better at lowering A1C. You might try adding acarbose if you aren’t already doing that.
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@Kelman I have a hiatal hernia (can’t swallow whole things) and chew the 1000mg pills. Just soft powdery easy to chew and swish with water. So yes break in half. BUT alldaychemist has 500mg that I bought.
Desertshoes just posted normal dosing 1000mg x 2. Which I have not deeply studied dose ranges so will gladly take Deserts comments as ok to go with.
Take care, curt
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Went through the article and I think it is wrong to think “Imeglimin is better than Metformin”
Assuming you are familiar with Metformin metabolism. Metformin and Imeglimin target overlapping metabolic goals using different pathways, which prevents them from canceling each other out. As a result, the effects of Metformin and Imeglimin are actually additive, which is rare for longevity interventions. So you want to take them both, not thinking one is superior and the other is inferior.
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You are most wise. Interested in your opinion to my take on Imeglimin.
Went through the article and I think it is wrong to think “Imeglimin is better than Metformin”
Assuming you are familiar with Metformin metabolism. Metformin and Imeglimin target overlapping metabolic goals using different pathways, which prevents them from canceling each other out. As a result, the effects of Metformin and Imeglimin are actually additive, which is rare for longevity interventions. So you want to take them both, not thinking one is superior and the other is inferior.
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I take imegliming because I no longer can tolerate metformin. I took metformin for decades and then developed a gastrointestinal aversion to it.
I won’t argue that it is better, but it certainly is easier on my stomach.
It keeps my A1C as low or lower than metformin.
I get my imiglin from India.
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Imeglimin directly amplifies insulin secretion from the pancreatic beta cells when glucose is high, and I wonder if this is the mechanism responsible for your A1C results. It is interesting nonetheless. I was kind of suggesting that if one can tolerate both, them take them both.
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What is your schedule and dosing level? 1000mg at breakfast and lunch?
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What is your schedule and dosing level?
I am on 1000 mg XR taken with OMAD.
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I space the doses approximately 12 hrs apart. With my morning keto coffee and right before dinner.
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Okay, turns out I was accidentally taking double the recommended dose for the last month. Instead of taking 1g 2x per day, I was taking 2g 2x per day (I mistakenly thought the pills were 500mg when in fact they were 1g.) The good news is I had 0 side affects and per Gemini, it doesn’t seem to be a big deal. They verified safety on a 2g/ 2x per day protocol, and the body just absorbs less if you take more, and it doesn’t accumulate. Could potentially be an issue if you have CKD, but my eGFR is fine.
Gemini:
Here’s what the pharmacokinetic data actually shows for your situation:
Absorption is self-limiting at high doses. Imeglimin absorption decreases as dose increases because it relies on active transport through organic cation transporters (OCTs), and that transport system saturates. Dose-normalized exposure (AUC) decreases with increasing dose, meaning the relationship is dose-dependent but less than proportional — phase 1 trials tested up to 8,000mg single doses without dose-proportional blood levels. Practically: doubling your dose to 2g BID almost certainly did not double your plasma exposure. You got more drug than intended, but not 2x more in your bloodstream. SpringerPubMed
No accumulation over your month of use. Plasma accumulation was minimal following repeated dosing, and the half-life is dose-independent, ranging roughly 9–20 hours in Caucasian subjects. That means each day essentially resets — there’s no evidence the drug builds up to higher and higher levels the longer you stay on a given dose, including the doubled one. By day 3-4 you’d have been at steady state, not still climbing. PubMedPubMed Central
Renal clearance is the variable that matters most for you now. Imeglimin is predominantly renally excreted, and dose adjustment becomes necessary specifically when eGFR drops into the 15–45 mL/min/1.73m² range (moderate-severe impairment) because exposure rises as renal clearance falls. This is exactly why I’d still want to know your current eGFR/Cystatin C — not because the overdose itself looks pharmacokinetically alarming, but because if your renal clearance is anything other than normal, your effective exposure over that month could have been meaningfully higher than a healthy-kidney person’s would be. ElmerpubWiley Online Library
Safety profile at high doses, per the phase 1 program: the studies tested up to 2,000mg twice daily in multiple-ascending-dose cohorts (i.e., exactly your accidental regimen) and found it “safe and well tolerated,” with adverse events being dose-dependent but mild and gastrointestinal — no signal for organ toxicity, no QT prolongation, no hypoglycemia risk to speak of as monotherapy. PubMed
Net read: the PK profile is reassuring — self-limiting absorption, no accumulation, mild AE profile even at your exact dose in trials, no metformin stacking. The one thing this data doesn’t tell me is your kidney function, which is the actual lever on how much of that month’s exposure mattered. Given you already track Cystatin C, pulling a current eGFR would close the loop — if it’s solid, this was very likely a non-event physiologically.
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