Dear Beth: unfortunately I do not live in the United States, at least for these health issues it would be much better, I could visit some Doctor expert in the subject and advise me first hand (like Dr. Green or Dr. Pelton), but where I live no one does these therapies, you can not ask for a sirolimus analysis, even paying the cost, there is no option in private laboratories, although I will ask. So there is no choice but to be self-taught and practice biohacking alone… while I read you I have been watching a video of Dr. Alan Green and I have discovered that Dr. Ross Pelton has a book about Rapamycin, which I am going to buy. I am very calm hearing that, in reality, you do not notice much difference when taking rapamycin in different hours, because that makes me think that in reality, side effects do not usually happen often. I train weights Monday, Wednesday, Friday and HIIT, Tuesday and Thursday. I think I will choose Sunday as the day of rapamycin. It’s already on its way, I’m about to receive it. A question: I was taking Urolithin A, but I have been seeing some study that is not conclusive with the benefit of taking it and since it is quite expensive, I have just finalised my last and I have not replaced it. What do you take it for? Do you see results? Thank you so much for answering 
I don’t want you to worry that you can’t get sirolimus labs done. Most people here, even in the US, never check. I took rapa for a year before I had labs done.
If I recall, I had a small inconsequential rash when I first started taking it. Other than just feeling great, I would never know I’m taking it at all. Many people don’t feel anything one way or another. I was so worried when I took my first pill, but it turned out it was a big nothing for me. Another person here can look at a pill and have all sorts of side effects.
The beauty is you will know by the side effects if you want to take less.
I only take UA in the hopes it might be doing something underneath the hood. I don’t feel a thing. So I would say, based on it not being a sure thing and being so expensive, if I wanted to save money, I would happily drop it with no thought at all.
Also, I’m in the minority that I have a doc involved in my rapa journey. My own doc happens to take it. Take comfort knowing most people here do not and can not get it through their doctors. And most don’t tell their doctors. Just know you are not alone in doing your own biohacking and never hesitate to ask questions.
May I ask were you live? If you live in europe there are ways to get rapamune.
Thank you very much for your reassuring words. Looking forward to starting!! I’m very happy that your own doctor is on this trip, that’s lucky!! Thank you again
Hello! Ask whatever you want :), I’m in Spain, I’m interested in that information, I got it in a company called Biolabs, I think it’s quite serious, but you never know…all information is welcome
Perhaps of interest: Has anyone from Europe (ideally Poland) Gotten Rapamycin From Abroad (India, etc)?
I live in Sweden and use this online doctor service. They issue a legally valid prescription, which I then use at one of my local pharmacies. There is an EU regulation stating that if you receive a prescription in one EU country (an EU‑valid prescription), you can use it in other EU countries as well. I have bought 100‑tablet packs of Rapamune four or five times using this type of prescription. However, not all pharmacies are aware of this law, and some refuse to dispense the medication.
How interesting! I’m going to investigate on the website. Of course, much more recommended than venturing to buy rapamicina by yourself… thank you very much
Thank you very much!
Hello again! I have been looking at the website and I find it very interesting, as they say you can request an online consultation, get a cross-border prescription from the EU and acquire a disease note valid throughout the EU, but… what do I tell the Dr. to prescribe me Rapamycin? Any suggestions that have worked for you? 
, thank you very much for your help, really
When I book the consultation, I would include something like the text below. I believe that once they read it, they’ll regard you as a candidate for targeted chronic therapy, and you might not even need a verbal consultation. They work for you—not for the standard care system—and they operate on the assumption that you’re an informed patient who knows exactly what you’re doing. Your next step is to find a pharmacy that’s well-versed in the legal framework within the EU.
"I am seeking a consultation regarding my case. My primary interest is slowing age‑related biological decline and improving long‑term healthspan. I am specifically looking to work with a clinic that are open to practicing longevity medicine and is informed about the use of Rapamune (sirolimus) in this context.
I actively track my health‑related biomarkers and follow evidence‑based lifestyle protocols. My understanding is that Rapamune is often used intermittently (for example, 5 mg weekly), and I am looking for a physician who can discuss this approach - prescription with me.
I would appreciate if you can review my case and determine whether I am a good fit for chronic therapy refill. "
Wow… very well explained! It will be very useful for me to write my application, thank you very much again
What drug interactions have you been aware of? You said you try not to take anything in your rapa day.
Hello, I understand that the question is not for me, I plan not to take anything the day I take Rapamycin and the next day, but I haven’t started taking it yet, so I can’t comment
Here is information related to foods/supplements: Rapamycin Frequently Asked Questions (FAQ)
If you are taking other medications I would check here for possible interactions: https://www.drugs.com/drug_interactions.html
Hello! At the moment I am collecting information to start taking rapamycin. It would be good for you to comment if you follow any complementary treatment for longevity: DASATINIB + quercetin, Fisetin + quercetin protocol of the Mayo Clinic (which I do cyclically), peptides (like Epitalon, I do peptide cycles too) and if you have noticed any good or bad effect, if you have taken it separately from rapamycin or indistinctly… everything that is to learn well will be, happy Sunday
I do fisetin/quercetin when I remember, I use a tirzepatide (glp1 peptide) weekly and a number of other longevity medications/practices.
Most people here use rapamycin and a variety of other longevity interventions they believe compliment it well.
I’ve done a cycle of epitalon before.
I used to use metformin but after finding the data on it to be not super great compared to SGLT2 inhibitors like empagliflozin I’ve swapped to empagliflozin.
I’m currently doing 36mg of astaxanthin a day.
Hello! I take 12 mg. of astaxanthin, why do you take 36 mg? Interesting what you say about empagliflozin, I’m going to study it. If you want to share more about supplements or practises for longevity it will be great! I have a lot of respect for glp1 peptides at the moment I have not used them. Do you take empagliflozin on the day of rapamycin or otherwise? You don’t use Epitalon anymore? I think that maybe when I start with rapamycin it turns out that several protocols that I do will no longer be necessary… which would also benefit my pocket, lol thanks for your contributions!
The ITP study of astaxanthin on mice that increased their lifespan by 12% used a lot more than the standard 12mg capsule. Additionally it has benefits for the skin protecting from UV damage, and it’s a really hot summer in Australia right now lol.
I take empagliflozin 4 days a week, it doesn’t happen to coincide with the day I take Rapamycin but that isn’t due to thinking there is an incompatibility. I don’t take it daily currently because I find it annoying that it increases frequency of urination, so I do 4 days on 3 days off.
GLP1 agonists help with sugar metabolism, so do SGLT2 inhibitors. The way I time mine is I take empagliflozin Monday, Tuesday, Wednesday and Thursday; and Thursday I take tirzepatide so that way I have coverage for sugar metabolism for the entire week quite solidly.
Epitalon should be cycled, not taken continuously.
Possibly. What protocols do you do?
Very good clarification about Astaxanthin, I take note and will increase it. Here in Spain we are in the middle of winter, cold, but in summer very hot, I don’t know Australia, I would love to, I would have to leave my biohacking supplements and hormones at home LOL!!. Do you think I could follow your empagliflozin method but with metformin? Here it is not easy to get empagliflozin, however, I have metformin for free (they prescribe it to my sister and she doesn’t take it… :swear_smile:) I see that you are a logical and methodical person, I’m going to turn around the issue of tirzepatide because I really liked your approach. I understand that, for some reason, empagliflozin is superior to metmormin, I will also study it. I do 2 annual cycles of Epitalon, Ukrainian protocol. I also do 2 cycles of: thymosin alpha 1, thymalin, Mots C, SS31, TB500, BPC 157, GHK-Cu… I take physetin / quecetin protocol from the clinic May: 1200 mg physetin/1,500 quercetin for 3 days every 2 months. I take quite a few supplements, although I am gradually suppressing those that are actually only a boom that will affect your economy and do not have conclusive studies or good results, I would like to add 2 days every 2 months of Dastinib + QUERCETIN, I left it impossible because I can not get Dasatinib here, but I will resume the topic to see if I can find it. I also want to do some Hyperbaric Chamber sessions soon, for example, a cycle of 10 sessions per year, if it doesn’t make me anxious to be there for an hour… I think it’s a good intervention. I take quite a few supplements: methyled B complex, fermented cod liver oil… Vitamin C, NAC, niacin, niacinamida, sulforaphane… I’m rotating them. I also use bioidentical hormone therapy: testosterone/oestrogen/progesterone/dhea. I take dried thyroid hormone, I have hashimoto, I take melatonin 10 mg. and 25 mg. of diphenhydramine at night, I sleep very well, as my Oura ring monitors me. I follow a diet low in simple carbohydrates and high in protein, I am putting fruits, but I want to see if triglycerides rise… in addition, if I start with rapamycin it is perhaps not a good idea… I do not eat processed food and no omega 6 vegetable oils, I take extra virgin organic olive oil, grass butter, or animal fat.