If you are in the US, after you get to what you think is your final dosing regimen, get labs done to check your sirolimus levels to make sure you are not under, or more importantly, over-dosing yourself
(I can’t remember the exact timing right now, but it’s 2-3 days after your dose)
You can order that test through gethealthspan.com for $25… and they have sales, so it can be had for even less.
FWIW, due to my lack of discipline/organization, I just take my weekly dose with no consideration to my food or time of day (I never notice a difference)
Oh, I also make sure not to have pomegranate within a couple of days because I was told that could affect it
The only thought I gave to my rapa day is to choose a day that gives me the biggest break from my resistance training. So, for instance, I do RT on M and W, pilates on Friday, so I take rapa on Sat.
The only thing I specifically don’t take on rapa days is my Urolithin A (not that there is harm, but I was told it was not a good use of money)
I accidentally found it a while back, but here are the results from perplexity
Pomegranate and its juice can increase rapamycin (sirolimus) absorption by inhibiting CYP3A4 enzymes in the gut, leading to higher blood levels of the drug. This interaction mirrors that of grapefruit and is noted in clinical guidelines for transplant patients taking sirolimus. Avoiding pomegranate products helps prevent potential toxicity from elevated rapamycin concentrations.
Dear Beth: unfortunately I do not live in the United States, at least for these health issues it would be much better, I could visit some Doctor expert in the subject and advise me first hand (like Dr. Green or Dr. Pelton), but where I live no one does these therapies, you can not ask for a sirolimus analysis, even paying the cost, there is no option in private laboratories, although I will ask. So there is no choice but to be self-taught and practice biohacking alone… while I read you I have been watching a video of Dr. Alan Green and I have discovered that Dr. Ross Pelton has a book about Rapamycin, which I am going to buy. I am very calm hearing that, in reality, you do not notice much difference when taking rapamycin in different hours, because that makes me think that in reality, side effects do not usually happen often. I train weights Monday, Wednesday, Friday and HIIT, Tuesday and Thursday. I think I will choose Sunday as the day of rapamycin. It’s already on its way, I’m about to receive it. A question: I was taking Urolithin A, but I have been seeing some study that is not conclusive with the benefit of taking it and since it is quite expensive, I have just finalised my last and I have not replaced it. What do you take it for? Do you see results? Thank you so much for answering
I don’t want you to worry that you can’t get sirolimus labs done. Most people here, even in the US, never check. I took rapa for a year before I had labs done.
If I recall, I had a small inconsequential rash when I first started taking it. Other than just feeling great, I would never know I’m taking it at all. Many people don’t feel anything one way or another. I was so worried when I took my first pill, but it turned out it was a big nothing for me. Another person here can look at a pill and have all sorts of side effects.
The beauty is you will know by the side effects if you want to take less.
I only take UA in the hopes it might be doing something underneath the hood. I don’t feel a thing. So I would say, based on it not being a sure thing and being so expensive, if I wanted to save money, I would happily drop it with no thought at all.
Also, I’m in the minority that I have a doc involved in my rapa journey. My own doc happens to take it. Take comfort knowing most people here do not and can not get it through their doctors. And most don’t tell their doctors. Just know you are not alone in doing your own biohacking and never hesitate to ask questions.
Thank you very much for your reassuring words. Looking forward to starting!! I’m very happy that your own doctor is on this trip, that’s lucky!! Thank you again
Hello! Ask whatever you want :), I’m in Spain, I’m interested in that information, I got it in a company called Biolabs, I think it’s quite serious, but you never know…all information is welcome
I live in Sweden and use this online doctor service. They issue a legally valid prescription, which I then use at one of my local pharmacies. There is an EU regulation stating that if you receive a prescription in one EU country (an EU‑valid prescription), you can use it in other EU countries as well. I have bought 100‑tablet packs of Rapamune four or five times using this type of prescription. However, not all pharmacies are aware of this law, and some refuse to dispense the medication.
How interesting! I’m going to investigate on the website. Of course, much more recommended than venturing to buy rapamicina by yourself… thank you very much
Hello again! I have been looking at the website and I find it very interesting, as they say you can request an online consultation, get a cross-border prescription from the EU and acquire a disease note valid throughout the EU, but… what do I tell the Dr. to prescribe me Rapamycin? Any suggestions that have worked for you? , thank you very much for your help, really
When I book the consultation, I would include something like the text below. I believe that once they read it, they’ll regard you as a candidate for targeted chronic therapy, and you might not even need a verbal consultation. They work for you—not for the standard care system—and they operate on the assumption that you’re an informed patient who knows exactly what you’re doing. Your next step is to find a pharmacy that’s well-versed in the legal framework within the EU.
"I am seeking a consultation regarding my case. My primary interest is slowing age‑related biological decline and improving long‑term healthspan. I am specifically looking to work with a clinic that are open to practicing longevity medicine and is informed about the use of Rapamune (sirolimus) in this context.
I actively track my health‑related biomarkers and follow evidence‑based lifestyle protocols. My understanding is that Rapamune is often used intermittently (for example, 5 mg weekly), and I am looking for a physician who can discuss this approach - prescription with me.
I would appreciate if you can review my case and determine whether I am a good fit for chronic therapy refill. "
Hello, I understand that the question is not for me, I plan not to take anything the day I take Rapamycin and the next day, but I haven’t started taking it yet, so I can’t comment
