I need help :), first time with rapamycin

#1

¡Hello everyone! I’ve been reading the forum for a long time, but I can’t clarify with several doubts: woman, 59 years old, thin, I exercise regularly, I have Hashimoto and hypothyroidism, I take bioidentical hormones, I’m starting to have some joint pain and some varicose vein in my legs, for the rest everything is fine, I had 3 children of natural birth at my twenties , I sleep well normally, little stress, I supplement, I do Fisetin/quercetin protocol every 2 months, I’m going to start taking rapamycin, I’ll start with low weekly doses, 1 mg., and I will increase depending on the side effects/tolerance as advised. Several are not clear to me Things: the day of the week that I take rapamycin I’m not going to take supplements and possibly not the day after, until I see how I feel, I have prepared azithromycin, cortisone… in case it had any of the most common side effects, the weekly day I take rapamycin what is it advisable to eat? Is it better to reduce proteins to support more M-tor? Yes? No? If I take metformin, is it recommended to take it at the same time or before? Later? Is it better to take rapamycin in the morning or at night? This question is because I take thyroid hormone, transdermal estrogen and testosterone cream, sequential progesterone

Blah blah blah And I don’t know if it’s more advisable to space anything you can take so as not to interfere with the rapamycin (I’ve already read about the possible increases: olive oil, grapefruit…) what markers in analytics would be advisable to do before starting? I have already read that later it is good to repeat them every 3 months to follow up, apart from cholesterol, hdl, ldl, glucose, insulin. What is good to monitor? Is there any book that you can recommend to me and that clarifies all these details? All comments are very welcome, thank you in advance

1 Like
#2

A lot of questions, I can’t answer them all.

I will say rapamycin in the morning is better than at night, as it can be very energizing.

With metformin appears to be ok, it synergizes quite well.

When I first started I limited protein. Now I don’t bother, simply because I can’t be bothered changing my diet particularly for one day a week.

#3

Thank´s so much. I know… a lot of questions. Your clarifications are very helpful, I have already resolved some doubts

#4

There are no hard and fast rules for these, most of us here try things out and see what works for us.

In terms of food to take with rapamycin; fatty foods will increase bioavailability by about 30%, which can be good if you want that (I take mine with sardines). Improve Bioavailability of Rapamycin (2)

Other food interactions to be aware of: Rapamycin Interactions with Other Food, Drinks, Supplements and Drugs

In terms of timing during the day to take rapamycin, some people find rapamycin energizing so prefer the morning, some people find rapamycin makes them feel tired for a while, so take it at night. More on dosing: What is the Rapamycin Dose / Dosage for Anti-Aging or Longevity?

Generally, see the FAQ for more responses: Rapamycin Frequently Asked Questions (FAQ)

#5

Thank you very much for the clarifications. I will try not to take too much fat, of course not grapefruit either the first shots, until I see how I feel, give me a little respect until I start using it and see how I feel. Thank you again

1 Like
#6

If you are in the US, after you get to what you think is your final dosing regimen, get labs done to check your sirolimus levels to make sure you are not under, or more importantly, over-dosing yourself

(I can’t remember the exact timing right now, but it’s 2-3 days after your dose)

You can order that test through gethealthspan.com for $25… and they have sales, so it can be had for even less.

FWIW, due to my lack of discipline/organization, I just take my weekly dose with no consideration to my food or time of day (I never notice a difference)

Oh, I also make sure not to have pomegranate within a couple of days because I was told that could affect it

The only thought I gave to my rapa day is to choose a day that gives me the biggest break from my resistance training. So, for instance, I do RT on M and W, pilates on Friday, so I take rapa on Sat.

The only thing I specifically don’t take on rapa days is my Urolithin A (not that there is harm, but I was told it was not a good use of money)

1 Like
#7

Was not aware of pomegranate. What does this do? The same as grapefruit?

1 Like
#8

I accidentally found it a while back, but here are the results from perplexity

Pomegranate and its juice can increase rapamycin (sirolimus) absorption by inhibiting CYP3A4 enzymes in the gut, leading to higher blood levels of the drug. This interaction mirrors that of grapefruit and is noted in clinical guidelines for transplant patients taking sirolimus. Avoiding pomegranate products helps prevent potential toxicity from elevated rapamycin concentrations.
​

1 Like
#9

Good to know, I’ve been drinking pomegranate juice a lot lately.

1 Like