Wow… very well explained! It will be very useful for me to write my application, thank you very much again
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What drug interactions have you been aware of? You said you try not to take anything in your rapa day.
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Hello, I understand that the question is not for me, I plan not to take anything the day I take Rapamycin and the next day, but I haven’t started taking it yet, so I can’t comment
Here is information related to foods/supplements: Rapamycin Frequently Asked Questions (FAQ)
If you are taking other medications I would check here for possible interactions: https://www.drugs.com/drug_interactions.html
Hello! At the moment I am collecting information to start taking rapamycin. It would be good for you to comment if you follow any complementary treatment for longevity: DASATINIB + quercetin, Fisetin + quercetin protocol of the Mayo Clinic (which I do cyclically), peptides (like Epitalon, I do peptide cycles too) and if you have noticed any good or bad effect, if you have taken it separately from rapamycin or indistinctly… everything that is to learn well will be, happy Sunday
I do fisetin/quercetin when I remember, I use a tirzepatide (glp1 peptide) weekly and a number of other longevity medications/practices.
Most people here use rapamycin and a variety of other longevity interventions they believe compliment it well.
I’ve done a cycle of epitalon before.
I used to use metformin but after finding the data on it to be not super great compared to SGLT2 inhibitors like empagliflozin I’ve swapped to empagliflozin.
I’m currently doing 36mg of astaxanthin a day.
Hello! I take 12 mg. of astaxanthin, why do you take 36 mg? Interesting what you say about empagliflozin, I’m going to study it. If you want to share more about supplements or practises for longevity it will be great! I have a lot of respect for glp1 peptides 
at the moment I have not used them. Do you take empagliflozin on the day of rapamycin or otherwise? You don’t use Epitalon anymore? I think that maybe when I start with rapamycin it turns out that several protocols that I do will no longer be necessary… which would also benefit my pocket, lol thanks for your contributions!
The ITP study of astaxanthin on mice that increased their lifespan by 12% used a lot more than the standard 12mg capsule. Additionally it has benefits for the skin protecting from UV damage, and it’s a really hot summer in Australia right now lol.
I take empagliflozin 4 days a week, it doesn’t happen to coincide with the day I take Rapamycin but that isn’t due to thinking there is an incompatibility. I don’t take it daily currently because I find it annoying that it increases frequency of urination, so I do 4 days on 3 days off.
GLP1 agonists help with sugar metabolism, so do SGLT2 inhibitors. The way I time mine is I take empagliflozin Monday, Tuesday, Wednesday and Thursday; and Thursday I take tirzepatide so that way I have coverage for sugar metabolism for the entire week quite solidly.
Epitalon should be cycled, not taken continuously.
Possibly. What protocols do you do?
Very good clarification about Astaxanthin, I take note and will increase it. Here in Spain we are in the middle of winter, cold, but in summer very hot, I don’t know Australia, I would love to, I would have to leave my biohacking supplements and hormones at home LOL!!. Do you think I could follow your empagliflozin method but with metformin? Here it is not easy to get empagliflozin, however, I have metformin for free (they prescribe it to my sister and she doesn’t take it… :swear_smile:) I see that you are a logical and methodical person, I’m going to turn around the issue of tirzepatide because I really liked your approach. I understand that, for some reason, empagliflozin is superior to metmormin, I will also study it. I do 2 annual cycles of Epitalon, Ukrainian protocol. I also do 2 cycles of: thymosin alpha 1, thymalin, Mots C, SS31, TB500, BPC 157, GHK-Cu… I take physetin / quecetin protocol from the clinic May: 1200 mg physetin/1,500 quercetin for 3 days every 2 months. I take quite a few supplements, although I am gradually suppressing those that are actually only a boom that will affect your economy and do not have conclusive studies or good results, I would like to add 2 days every 2 months of Dastinib + QUERCETIN, I left it impossible because I can not get Dasatinib here, but I will resume the topic to see if I can find it. I also want to do some Hyperbaric Chamber sessions soon, for example, a cycle of 10 sessions per year, if it doesn’t make me anxious to be there for an hour… I think it’s a good intervention. I take quite a few supplements: methyled B complex, fermented cod liver oil… Vitamin C, NAC, niacin, niacinamida, sulforaphane… I’m rotating them. I also use bioidentical hormone therapy: testosterone/oestrogen/progesterone/dhea. I take dried thyroid hormone, I have hashimoto, I take melatonin 10 mg. and 25 mg. of diphenhydramine at night, I sleep very well, as my Oura ring monitors me. I follow a diet low in simple carbohydrates and high in protein, I am putting fruits, but I want to see if triglycerides rise… in addition, if I start with rapamycin it is perhaps not a good idea… I do not eat processed food and no omega 6 vegetable oils, I take extra virgin organic olive oil, grass butter, or animal fat.
If you need metformin for diabetes use it as your doctor has prescribed. Otherwise you are free to experiment how you wish.
You can get essentially any medication incredibly cheap anywhere in the world without a prescription through online pharmacies. The one I recommend is https://www.shreejiimpex.co.in/
They sell rapamycin, empagliflozin, metformin and more. I’ve been able to experiment with so many longevity medications I otherwise couldn’t have due to this.
Be sure to get good brands if you get medications off this website. Some are better than others. Refer to this Generally Good Indian Pharma Companies
Nice haha.
You can get it from https://www.shreejiimpex.co.in/
I want to try this too.
I use testosterone/dhea/hcg. What does progesterone and estrogen do for you? I figure I make enough estrogen from test/dhea/hcg.
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No, I don’t have diabetes, the doctor prescribes metformin to my sister because she has high glucose, without even being pre-diabetes, according to her scales… and since she doesn’t want to take it, she offers it to me for free lol. Thank you very much for the link for the medicines, here in Spain we have to be very careful because the customs checks and confiscates everything, in its inexhaustible eagerness to charge tariffs … of 21% plus the management costs, pathetic. … before I made purchases constantly in other countries, but suddenly all the purchases began to stop and now you have to be careful because you are left without the product and maybe without the money … I buy a lot in the US because the products already come with ore-paid taxes, also in the UK and in the EU, there without problems, but I am going to investigate it. Progesterone and oestrogen do everything for me: wink:, for the moment they make me have an ovulation and a menstruation every month, just like in my 20 years. But not a fictitious menstruation: a real ovulation, controlled by my Oura ring that tracks ovulation and menstruation through daily temperature control. Both have many beneficial properties for women’s health, best regards
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I have taken rapamycin since the fall of '23. I am now 75- almost 76- and was on 15mg compounded once a week> now I have switched to a straight 3mg of sirolymus every week. I don’t take anything else with it, have not changed my diet at all. The only thing I’ve noticed is I don’t get as gassed when I’m mowing the lawn in the summer
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I used AI to help but the reply is pretty good: On a practical level, she can keep her protocol simple and consistent, start low, and mainly focus on safety monitoring and avoiding obvious interactions.
How to take rapamycin
Once weekly, same day and time, with a normal healthy meal that includes some healthy fat (e.g., olive oil, avocado, nuts).
No strong human data that she must cut protein on dose day; reasonable to keep overall weekly protein adequate for muscle and joints and, if desired, go a bit lighter on protein and high‑sugar carbs that day.
Avoid grapefruit/Seville orange, and keep dose day similar each week so exposure is predictable.
Timing with metformin and hormones
Metformin: keep whatever schedule she already tolerates (e.g., with dinner); rapamycin can be taken with a different meal the same day so side effects are easier to attribute.
Thyroid: continue on an empty stomach as usual; the timing does not need to change for rapamycin.
Estrogen/testosterone/progesterone: keep current schedule; no strong evidence that exact timing relative to rapamycin matters.
Labs and monitoring
Before starting: CBC, CMP (kidney, liver), fasting lipids, fasting glucose, insulin or HbA1c, TSH/free T4 (± free T3), hs‑CRP, and sex hormones as her doctor usually checks.
Repeat about every 3 months in the first year to track lipids, glucose/insulin, blood counts, liver/kidney function, and adjust dose if needed.
Other practical tips
Reasonable to simplify supplements on the first one or two dose days so she can see how she feels, then add them back once tolerance is clear.
Self‑starting stored azithromycin or cortisone is not ideal; better to pause rapamycin and contact her doctor if she develops significant infection or concerning symptoms.
Good, readable resources include Ross Pelton’s Rapamycin: mTOR, Autophagy and Treating mTOR Syndrome and podcast discussions with Matt Kaeberlein or David Sabatini for nuanced risk–benefit context.