How to Stop or Reverse Skin Aging (2026)

#87

I’m a long time tret and spf devotee.

I was occasionally using retinol on my body with acids (not daily out of laziness) and just replaced it with a touch of low dose tret mixed into a lotion.

I use a body wash with enzymes which works well to soften with no effort, but I just learned here that 12% lactic acid (or equivalent) is key to skin thickening. You could read a newspaper through my skin,even when I was young, so I’m intrigued by this. I always say if this longevity shtick works, I might outlive my skin!

After reading Relaxed Meatball’s review, I started using One Skin two months ago and adore it. Their lip mask is now my favorite thing to put on before bed. I have no idea if their cream is doing anything magical, but I love using it and my skin is very happy. I will be repurchasing.

I’ve made one batch of rapa serum but have been too lazy to make it again. Partially, it’s because I never know which things I can mix together without deactivating the active ingredients… one skin peptides, rapa, tret, acids, etc. I was all ready to buy ghk-cu powder to mix in, but once again, paralysis by analysis.

Recently, instead of washing right after applying my estradiol gel, I’ll wipe any excess on my face (thanks to the discussion here). I’m only doing part of my face so if I have any kind of result, I’ll eventually notice… not expecting anything, but ??

On some mornings I’ll put a cheap vit c on my face (Timeless) as insurance.

A few months ago I stopped using my very expensive exosome serum that contained many steps in one… my skin is no worse.

Oh, and red light therapy a few days per week… again, no idea if it’s doing anything but I enjoy it.

@medaura ha, I just saw your last comment… well, I’m turning 60 this month… when you are my age, you’ll start looking for all the shinny objects you can find :)!

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#88

Hahaha shiny object tip: Sculptra!

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#89

No kidding! My face used to be more toxic than Chernobyl, and I looked great until I realized I over did it!! I let all of it dissolve (and paid to have some of it taken out… talk about insult to injury!)

My face currently only has worn off Botox at the moment… I’m in desperate need of some volume but I’ve been procrastinating going down that rabbit hole again… the puffy face sorta creeps up on you!

#90

How do you dissolve Hesperine effectively for topical use? Pure Hesperidin has very poor solubility in both water and oil. In its raw form, it tends to precipitate out, which can feel “gritty” or simply sit on top of the skin without penetrating.

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#91

I dissolve it in a few drops of Tanscutol and then mix with HA toner.

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#92

Yeah lactic acid is totally under-rated, the best one is from Korea called Anua 10+ recommended by Doctorly of youtube. It does a great job for giving you an overall polished look.

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#93

I need to start using lactic acid. I’ve put glycolic acid from the brand The Ordinary in a spray bottle and spray this all over my body (minus the face) 2-3x a week after I shower.

Topical estradiol and estriol cream/gel on the face for men is also fine. The amount needed to apply to the face to increase collagen production isn’t enough to throw hormone balance out for most guys. I do it occasionally. It’s alternative active to retinoids.

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#94

There you go. It is definitely not systemically absorbed. But I didn’t know whether men’s skin was responsive. I wouldn’t use it as an alternative to retinoids. Use them together for really good results.

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#95

I don’t understand this because absorption is the exact goal of my gel (hrt).

#96

I can’t use retinoids every night as my skin is quite sensitive. I can alternate and use other actives like estradiol gel, estriol cream, azeliac acid, urea cream, etc.

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#97

Some good news on Ginseng for skin health and fertility… New Evidence Links Ferroptosis to Ovarian / Fertility Decline but Ginseng Defends

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#98

https://x.com/davidasinclair/status/2052724890441019629?s=46&t=ujBXvjsf5sfNM8J1qi8RfQ

DHM compound could be found on Amazon and added to DIY formulations.

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#99

Full details on paper here: Reversing the Clock: Epigenetic Serum Slashes Skin Age by Two Years Across All Skin Tones

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#100

Looks pretty subtle to me but Am thinking of making a DIY serum and dissolve a bunch of goods in transcutol then water. So adding this to my shopping list.

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#101

A lot of things seem to influence gene expression and epigenetic profile of skin – lasers, heat, copper peptides, etc. Maybe even just something like Amlactin and/or retinols over time can do it.

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#102

I am a little confused. I got sirolimus cream from India for dirt cheap. Should I not be using it for anti-aging?

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#103

Rapamycin at 16 μM resulted in hair loss and open wounds. Rapamycin 16 μM is about 0.0015%.

rapamycin, n = 17. Rapamycin at 100 nM gave similar results as 1.6 μM (Figure S2). Similar effects by rapamycin were seen in female mice (Figure S2B). Rapamycin at 16 μM, however, resulted in hair loss and open wounds, (data not shown), consistent with a previous vascular grafts study in rats receiving high-dose rapamycin (Walpoth et al., 2001); this may be due to more severe inhibition of mTOR, …
https://www.sciencedirect.com/science/article/pii/S2211124719306990?utm_source=chatgpt.com#mmc1

Rapamycin 0.1% cream is about 66 times higher than the hair loss concentration (16 μM =~ 0.0015%).

Retinol helps anti-aging of facial skin. It also helps hair regrowth when applied to scalp. There is no clear boundary between facial skin and scalp. Scalp is skin too.

But, if rapamycin cream 0.1% is applied for facial skin, its concentration is much higher than the concentration resulting in hair loss.

An anti-aging cream on facial skin resulting in hair loss? Does it make sense?

My thought so far is that rapamycin cream 0.1% was developed for severe skin diseases, not anti-aging.

If you have rapamycin cream 0.1%, I think that you can mix a small tip of the cream with other general skin cream to lower the concentration to be around 10 μM(or 0.001%).

Following is the references about the Rapamycin concentration.

Rapamycin at 16 μM does not enhance hair regeneration (data not shown); this may be due to more severe inhibition of mTOR which was reported to be required for HFSC activation (Castilho et al., 2009; Kellenberger and Tauchi, 2013; Deng et al., 2015
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30699-0?sf214499969=1

This paper presented three reference papers supporting it besides its own experiments as above. So, the concentration is pretty solid and concrete number supported by multiple researches.

A user here pointed out a similar issue in another thread before:

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#105

Damn. Now I don’t want to use it anymore

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#106

Why did you delete that post? Was something in error?

#107

I mistakenly posted the same reply two times, so I deleted it. Please delete it completely including this reply if you can. I am new to use this website, and It was not easy for me to post a reply. You can see my original reply above.

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