I am a little confused. I got sirolimus cream from India for dirt cheap. Should I not be using it for anti-aging?
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Rapamycin at 16 Ī¼M resulted in hair loss and open wounds. Rapamycin 16 Ī¼M is about 0.0015%.
rapamycin, n = 17. Rapamycin at 100 nM gave similar results as 1.6 Ī¼M (Figure S2). Similar effects by rapamycin were seen in female mice (Figure S2B). Rapamycin at 16 Ī¼M, however, resulted in hair loss and open wounds, (data not shown), consistent with a previous vascular grafts study in rats receiving high-dose rapamycin (Walpoth et al., 2001); this may be due to more severe inhibition of mTOR, ā¦
https://www.sciencedirect.com/science/article/pii/S2211124719306990?utm_source=chatgpt.com#mmc1
Rapamycin 0.1% cream is about 66 times higher than the hair loss concentration (16 Ī¼M =~ 0.0015%).
Retinol helps anti-aging of facial skin. It also helps hair regrowth when applied to scalp. There is no clear boundary between facial skin and scalp. Scalp is skin too.
But, if rapamycin cream 0.1% is applied for facial skin, its concentration is much higher than the concentration resulting in hair loss.
An anti-aging cream on facial skin resulting in hair loss? Does it make sense?
My thought so far is that rapamycin cream 0.1% was developed for severe skin diseases, not anti-aging.
If you have rapamycin cream 0.1%, I think that you can mix a small tip of the cream with other general skin cream to lower the concentration to be around 10 Ī¼M(or 0.001%).
Following is the references about the Rapamycin concentration.
Rapamycin at 16 Ī¼M does not enhance hair regeneration (data not shown); this may be due to more severe inhibition of mTOR which was reported to be required for HFSC activation (Castilho et al., 2009; Kellenberger and Tauchi, 2013; Deng et al., 2015
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30699-0?sf214499969=1
This paper presented three reference papers supporting it besides its own experiments as above. So, the concentration is pretty solid and concrete number supported by multiple researches.
A user here pointed out a similar issue in another thread before:
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Damn. Now I donāt want to use it anymore
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Why did you delete that post? Was something in error?
I mistakenly posted the same reply two times, so I deleted it. Please delete it completely including this reply if you can. I am new to use this website, and It was not easy for me to post a reply. You can see my original reply above.
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You can mix your rapamycin cream with other general skin cream to lower the concentration. It is good that you can cut down the price of rapamycin cream almost 10 times.
If you are not sure that the concentration of your rapamycin cream is below the concentration resulting in hair loss, you can avoid using it near scalp. However, you can still use it for skin except areas you expect growing hairs.
I think that ideally the best way is to maintain the concentration of rapamacin cream in a level promoting both hair growth and skin improvement. Then, you can use the cream both in skin and scalp.
I am using retinol cream both on my facial skin and scalp around my hair line. I will feel better if I can use rapamycin cream in the same way.
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I have been applying it with a moisturizer, Tretinoin (4x weekly), AHA/BHA (2x weekly), or vitamin C serum so I never use it on its own. Perhaps thatās a good thing for lowering the concentration.
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Iāve experimented with an 80:20 combo of estradiol:estriol cream on my face a couple of separate nights before bed and more than any other topical active I notice I wake up with better looking skin.
According to various AI models Iāve talked to about this they state estriol is likely a safer option longer term due to only agonising estrogen receptor beta, whereas estradiol agonises both ERa and ERb. I have tried estriol alone a number of times, I donāt recall having as dramatic an effect as the combination of estradiol and estriol.
This is what Claude says about the different estrogen receptors:
Dermatologist Shops Costco Skincare | Whatās Worth Buying?
I. Executive Summary
This assessment identifies eleven specific dermatological products recommended by the speaker for their formula stability, ingredient efficacy, and cost-efficiency. The speaker prioritizes topical agents that modulate the skin barrier and dermal structure, specifically those containing niacinamide, centella asiatica, and alpha-hydroxy acids. A central theme of the recommendations is the āK-Beautyā (Korean Beauty) sector, which the speaker evaluates as having superior price-to-performance ratios for hydrating and anti-inflammatory formulations.
Among the top-tier recommendations is Beauty of Joseon Dynasty Cream, valued for its use of niacinamide to inhibit melanosome transfer and rice bran water for hydration. Similarly, Skin1004 Madagascar Centella Soothing Cream is highlighted for its inclusion of centella asiatica and tranexamic acid, which address redness and barrier repair. The speaker also endorses Torriden products, specifically the Cellmazing Firming Gel Mask for its occlusive properties that maximize the penetration of humectants and reduce transepidermal water loss (TEWL).
In the Western retail category, the speaker confirms the clinical utility of AmLactin (12% Lactic Acid), citing its ability to address dermal atrophy and increase dermal thicknessāa claim backed by its status as an alpha-hydroxy acid with significant molecular penetration. For general body care, Neutrogena Hydro Boost Hyaluronic Acid Body Lotion and Aveeno Skin Relief Healing Ointment are recommended for their ability to maintain skin suppleness and reduce inflammatory markers via colloidal oat avenanthramides.
The speakerās methodology for recommendation relies on āR&D footprints,ā specifically praising Olay Every Night Retinol for its formulation stability and penetration testing. Conversely, the speaker aggressively filters out oral supplements, such as Natureās Bounty gummies, due to diagnostic interference risks (biotin) and hepatic toxicity concerns (vitamin A), reinforcing a ātopical-firstā intervention strategy for dermatological longevity.
II. Insight Bullets
- Beauty of Joseon Dynasty Cream: Recommended for its dual-action niacinamide and rice bran water; effective for moisture barrier support and pigment management.
- Skin1004 Madagascar Centella Soothing Cream: Validated for its high centella asiatica content, specifically for soothing active redness and improving the appearance of red stretch marks. Bylka et al., 2013.
- Torriden Cellmazing Firming Gel Mask: Endorsed for its superior occlusion, allowing for āglassyā skin results through maximum hydration retention.
- Olay Every Night Retinol: Selected for its high-quality research and development; the speaker notes Procter & Gambleās rigorous penetration testing.
- RoC Advanced Hydration+ Water Cream: Recommended as a fragrance-free alternative to traditional gel-creams, utilizing marine extracts for humectant-based hydration.
- Neutrogena Hydro Boost Hyaluronic Acid Body Lotion: Praised for its lightweight, non-greasy texture and efficacy in improving skin suppleness to prevent stretch mark severity.
- Aveeno Skin Relief Healing Ointment: Noted for its high glycerin content and oat-derived avenanthramides, which provide anti-inflammatory benefits. Pazyar et al., 2012.
- Round Lab 1025 Dokdo Cleanser: Recommended as a gentle, Korean alternative to classic Western ānon-soapā cleansers; includes ceramides and hyaluronic acid.
- Torriden Dive In Serum: A recommended hyaluronic acid serum for those in hot, humid climates seeking lightweight hydration without heavy occlusion.
- Grace & Stella Eye Patches: Validated for acute de-puffing and fine-line reduction via hydration and thermal effects (if refrigerated).
- AmLactin 12% Lactic Acid Lotion: Highly recommended for āswearing byā results in reversing dermal atrophy and thickening the skin. Smith, 1996.
- Colloidal Oat Efficacy: Specifically identified as a superior skin protectant for atopic dermatitis and barrier repair in the Aveeno formulation.
- Niacinamide Mechanism: Validated for its unique ability to block pigment transfer from melanocytes to surface skin cells. Greatens et al., 2002.
- Tranexamic Acid Redirection: Recommended topically for redness/moisture barrier, while acknowledging its oral use is reserved for systemic pigment treatment.
- Occlusion Benefits: The speaker emphasizes that the ābouncyā skin effect from masks is a result of trapped water, not new collagen fiber synthesis.
IV. Actionable Protocol
High Confidence Tier (Level A/B Evidence)
- Dermal Thickening Protocol: Use AmLactin (12%) daily on sun-damaged areas to improve skin density. Warning: High concentration lactic acid increases UV sensitivity; apply broad-spectrum SPF 30+ daily.
- Retinoid Integration: Olay Every Night Retinol is identified as a stable entry point for nocturnal skin cell turnover. Apply a pea-sized amount to dry skin to minimize irritation.
- Anti-Inflammatory Cleansing: Utilize Round Lab 1025 Dokdo Cleanser with lukewarm water. Ensure thorough rinsing of the mandibular area to avoid contact dermatitis.
Experimental Tier (Level C/D Evidence)
- Post-Inflammatory Erythema (PIE) Management: Apply Skin1004 Madagascar Centella or Beauty of Joseon Dynasty Cream (Niacinamide) to red spots or āactiveā stretch marks to dampen the inflammatory cascade.
- Targeted Eye De-puffing: Store Grace & Stella Eye Patches in the refrigerator. Apply chilled for 10-15 minutes to induce vasoconstriction and reduce edema.
Red Flag Zone (Safety Data Absent / High Risk)
- Avoid: Natureās Bounty Hair, Skin, & Nails Gummies. These contain Biotin which causes false cardiac/thyroid lab results and Retinyl Palmitate which poses hepatic risks.
- Avoid: Hot Water Washing. Cease using high-temperature water on the face as it dissolves the skinās natural lipid barrier regardless of the cleanser used.
- Avoid: Topical Collagen for Wrinkles. Do not purchase products like the Torriden Mask expecting the collagen to āfillā deep wrinkles; use it strictly for surface hydration.