Signed, thanks! I really hope they get the renewal 
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Thanks for signing. Welcome to the group and thank you for the link. Helpful study. Would you be willing to share the ages and dosing regimen of your dogs. Still trying to figure that out. Will also post a separate dosing question on this thread 
.
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Certainly! The oldest is 10 and just over 40 lbs. He was diagnosed with b cell lymphoma last year and has been in CHOP-MA treatment and complete remission for over a year now. The girls are 8 and 5 respectively and around 60 lbs each. I am starting them on the dosage in the TRIAD study at .15 mg/kg weekly rounding to the nearest mg - so 3 mg for the boy and 4 mg for the girls. All are mixed breed rescues Iāve had since they were puppies.
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Thanks for sharing, Sara. Iāve had a B-cell lymphoma 14 y.o. Who underwent CHOP to complete remission. Wish a rapamyacin protocol had been around then.
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Perhaps of interest for people here, there must be a recording somewhereā¦
Dr. Daniel Promislow, leader of the Dog Aging Project, on the Talking Animals Radio Show this Jan. 24, at 11am ET, on WMNF (88.5 FM) in Tampa, streaming at WMNF.org.
Website:
Podcast:
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Any response from TriviumVet?
Nope! Nothing at all 
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These are the only references I found on an internet scrape:
āI also think, you know, itās unfortunate, but a lot of scientists do whatās easy. And, because of the reputation problems, thereās more work involved in getting a clinical trial going with rapamycin and getting it through the IRB. Thereās also a little bit of shiny new object syndrome in this field. And I think people have known rapamycin works really well in preclinical studies and havenāt paid as much attention as they probably should have. And then of course, rapamycin is off patent, and itās been off patent for many years. And so there hasnāt been a lot of incentive for companies to move forward with clinical trials for rapamycin for other indications. That, I think, is being helped by newer versions of rapamycin. For example, thereās a company called Trivium Vet, that has a version of rapamycin thatās enteric coated for better release in the intestine. There are some other potentially more mTORC1 specific inhibitors that are rapalogs that are being developed. And then of course, the catalytic inhibitors that I talked about.ā
https://mkaeberlein.com/rapamycin-is-the-gold-standard-for-longevity-interventions/
From 2021:
āThe drug will be given once a week based on the human data from clinical trials with everolimus, which is a rapamycin derivative. It seems that an equivalent total dose given once a week rather than daily has better efficacy with reduced side effects. We are using a form of rapamycin that is coated for enteric release. Itās not the eRapa (encapsulated rapamycin) thatās used in mice, thatās a different formulation, but it is also not exactly the same as generic rapamycin (sirolimus) tablets that organ transplant patients take.ā
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Started my 5kg 8.5-9.5 y.o. mixed breed in the beginning of February. Using Rapacan to start. Splitting the 1 mg pills in quarters, putting into a cheese coated enteric coated capsule and dosing with a higher fat meal. The plan was to titrate up towards the high end of the previous DAP study dose (.15mg/kg) and wasnāt sure if Iād give once weekly or divide it up into 3xās/week based upon Matt Kās worry about the dose being a little low, very few to almost statistically absent adverse effects from the previous trial and thinking once per week was really to enhance compliance from dog owners. We started at .25mg once per week and weāre up to .25mg twice per week. This thread and others on this forum have been invaluable in helping us figure out sourcing and dosing. Very grateful for that . Many thanks to everyone here.
He is definitely friskier, drivier, and has increased intensity and stamina. This has enhanced all of his great characteristics and some of his less attractive traits like resource guarding and separation anxiety. Overall realizing more energy in both directions. Perhaps what we saw as maturity and mellowing was aging and less energy 
. We could usually kick back after dinner and watch the news or a movie, but he now demands more stimulation (and food), so we have added more training and brain games in the evening.
Heās developed a sore on his belly unlike any heās ever had. He doesnāt get hot spots and the rest of his belly isnāt red and irritated. I wonder if this might be from the rapamycin, maybe his version of the canker sores humans often get on rapamycin. Weāre going away for a week and I think it might be a good time to take a weekās hiatus. And now, we may not be titrating any further at this time.
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Great post, thanks for sharing.
I suspect the red sore is associated with the rapamycin use. Temporary skin rashes and sores are pretty common with rapamycin. Take a break and I bet it goes away.
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We see all of this wonderful data on Rapamycin in mice and dogs. It just confirms for me that Rapamycin is helping humans as well. Thanks for sharing your stories!
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Is anyone not using pill form rapamycin for their dog? I have rapamycin powder Iād like to start giving my dog (~70lb rough collie 3.5 years old), but Iām not sure about the best way to administer it.
Also, mine was purchased from a US chemical supplier and I the purity was quoted as 98%+. Can anyone recommend a quantitative testing service that isnāt prohibitively expensive?
I think youāll find it not worth the hassle to do what youāre trying to do. I would just use the rapamycin powder for Rapamycin toothpaste, or rapamycin skin cream, and buy regular tablets for your dog.
You can buy rapamycin tablets from India for about $1.20 or less per 1mg tablet, that you know will work. To make your ownā¦ and to do blood tests on your dog (I donāt think blood sirolimus levels for dogs are even available) is hard, and expensive, and if you canāt do the blood tests you donāt know if the rapamycin is even getting into the blood.
Its hard due to the fact that rapamycin typically gets destroyed in the stomach acid, if it doesnāt have good protection.
I recommend you review these posts. And perhaps anyone who has been successful in this effort can add their thoughtsā¦
here: Rapamycin enteric coating vs powder bioavailability
here: How many are making their own solutions from powder?
here: New Peter Attia interview w/Matt Kaeberlein, inferior bioavailability of encapsulated rapa
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Do you think the belly sore was an indication we needed a slower ramp on titrating? Can you share the ramping protocol you used for your pup? I remember you saying it was slow. TIA
Its a little more difficult to ārampā when you have a small dog. My dog weighs 24 lbs. And you canāt split sirolimus tablets. So I started with 1mg, and perhaps 2 months later went up to 2mg. I generally try to do my dog on the same schedule Iām on so its easy to remember.
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Thank you @RapAdmin. I guess Iāll just use it to make my own topical, and perhaps make some toothpaste also.
I need to look into ordering some from overseas. The last time I checked the prices they actually werenāt much cheaper than my Healthspan subscription. But if Iām going to be ordering for my dog, and Iād also like to order some for friends and family members, Iām going to have to shop around a bit.
Talks from WVC 2024- Nutrition for Lifespan Extension and Frailty
Source: Talks from WVC 2024- Nutrition for Lifespan Extension and Frailty |
Hello everyone,
I am new to the group but I have been reading the posts and found a lot of useful information. My 7 year old Standard Poodle just started taking rapamycin 10 days ago for overall health preventative purpose. I am ordering the capsules from Dr. Kevin Toman. But I was just informed that the compounding pharmacy he has been using is retiring/closing so he will switch to generic rapamycin tabs and the cost for 3 mg doses will be higher since he has to combine 1mg and 2 mg tabs.
So reading about reputable pharmacies in India on here, I ordered some Zydus 1mg tabs. I trust Zydus since their brand is FDA approved. The cost is much less compared to getting it from Dr. Toman, even Zydus brand is the most expensive one out of all the generic offered from India.
Our dog is getting 3 mg three times a week dosage and so far doing well.
Hope to share and learn more about rapamycinās use in dogs.
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Welcome to the forums. Please post periodically on how your dog is doing and update us. Are there any specific issues of age that your dog is suffering from yet? Have you seen any change in the dogās energy level or playfulness or any other metric (good or bad)?
Thank you for the welcome. I will post updates. 
No specific issues we are trying to address but the data we have so far really make sense to me that rapamycin can help improve health span, not just life span. So far, I havenāt notice any changes but it has only been one week and half since he started. I am sad to learn that the current DAP study doesnāt have enough funding to continueā¦so I didnāt want to wait any longer before starting our dog on it.
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