How Do I Get Rapamycin for My Dog?

We are not cats and cats are not humans. Our physologies are different from each other. The study you cite is small and includes felines who are already have serious cardiovascular issues. It’s hard to know if any subject succumbed due to or in part to rapamycin. But for those who survived, it doesn’t appear that there were many serious adverse effects.

We are discussing doses for longevity on this thread. To translate treatment dosages for cardiomyopathy in felines and longevity in dogs and humans will not prove to be an accurate baseline.

If you look at doses for organ for humans over 40mg, rejection, the loading dose is 6 mg with 1 mg per day and up to 15 mg with 5 mg/day for those on cyclosporine. This is every day, not weekly or three times a week

This is what you should focus on and not translationally why the dose is higher in cats than dogs or humans for longevity.

This thread is a fantastic forum for an exchange of ideas on a new frontier. But I fear that many of these questions should be directed to a supportive veterinarian. If you don’t have a supportive veterinarian of rapamycin, going to Petspan is always an option.

I am going to give 1mg to my 10lbs dog (once a week). I am going to order soon.

I initially thought this was going to be little too much but this study dosage is way more, yes not dogs but they saw better results with a higher dose.
https://www.sciencedirect.com/science/article/abs/pii/S1053249802005715
Results:

Rapamycin (0.5 mg/kg/day) inhibited intimal hyperplasia, medial ECM accumulation and expansive vascular remodeling (increasing vessel circumference) in rat aortic allografts. This was associated with attenuation of the graft inflammatory infiltrate and a reduction in intragraft gelatinase, collagen III and tissue inhibitor of metalloproteinase 1 (TIMP 1) mRNA levels. At a lower dosage (0.25 mg/kg/day), rapamycin inhibited intimal hyperplasia and medial ECM accumulation, but there was a lesser effect on vascular remodeling. Lower dose allografts were also seen to have a more severe inflammatory infiltrate and larger amounts of intragraft matrix metalloproteinase 9 (MMP 9) mRNA than those treated with the higher dose.

Has anyone seen this?

I am scared now!

Why are you scared?

Effects of metformin, rapamycin, and resveratrol on cellular metabolism of canine primary fibroblast cells isolated from large and small breeds as they age

We found that rapa and res increased rates of non-glycolytic acidification in small and large breed puppies and basal oxygen consumption rates (OCR) in small and large breed puppies. Rapa increased proton leak and non-mitochondrial respiration in small and large breed puppies. Maximal respiration was significantly altered with rapa treatment but in opposing ways: large breed puppies showed a significant increase in maximal respiration when treated with rapa, and small old dogs demonstrated a significant decrease in maximal respiration when treated with rapa. In opposition to rapa treatments, met significantly decreased basal OCR levels in cells from small and large breed puppies. Our data suggest that rapa treatments may be metabolically beneficial to dogs when started early in life and more beneficial in larger breeds.

From the whole article as much I understood, I thought this wasn’t good for small old dogs. Then I asked in another forum and someone did a summary and said It looks like Rapamycin may be detrimental to older smaller dogs.

  • Large Breeds: Benefit significantly from early-life treatment due to improvements in mitochondrial function.
  • Small Breeds: While puppies benefit from enhanced metabolism, older dogs may experience reduced mitochondrial capacity with treatment.

But I also read real life stories that even smaller/older dogs benefited from Rapa. I don’t want to miss the potential good for my dog but I also don’t want to give him problems.

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Rapamycin does a lot of things at different doses. You can focus on one small issue at a specific dose in a specific situation but I think you have to look at the overall results in every species and model organism it’s been tested in. In virtually every situation the medium and maximum lifespans increase over the control groups.

Of course not every one of the treated group lives longer. In all of this we are taking a probabilistic approach. The good news is that we can monitor our dogs and ourselves (who are taking the rapamycin) can pause or adjust if the results are not what we want

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Still on rapa? Could you give any update? Thx.

I was just saying that I think my 3 elderly cats are much perkier since starting on rapa

Well, one cat just attacked another one, ripping out hair and causing a lot of bleeding. This has never happened in 17 years. It then dawned on me you mentioned your dog become more aggressive. Now I wonder if it’s related. Sigh.

Has anyone heard of this happening in the dog study?

In Kaeberlein’s study only non-reactive dogs are for candidates for the trial.

I am using rapamycin for my companion animal in coordination with a veterinarian who is, himself, a researcher and has experience with rapamycin. Again, if you do not have access to this type of veterinary care locally, you might want to consider PetSpan. You can see Dan’s comments above.

https://www.petspan.com/

Kelsey, I really appreciate your concern, that is very kind of you. Thank you for making sure my cats have good care. Because you’ve shown your concern twice, I’ll share that I am fortunate to have one of the top IM vets in NorCal, and she is familiar with rapamycin.

I am simply on here just to share information and ask questions, similar to what many forum members do, even those who are fortunate enough to have excellent doctors who give great advice on rapamycin.

It might wind up being helpful for those who see something unexpected, like the incident today from a very mild mannered cat, to share it here incase we eventually see a trend. That is why I was curious if anyone knew if it happened in the dog study. If anyone has heard, do let me know because one incident at my house after 17 years does not show any sort of connection. It’s just a wonder at this point. Thanks

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