Continued the 10 additional repetitions per set… breezed through.
Arms and chest felt swole last night in bed and at gym today… solid. And, ass cheeks plump this morning in shower waahing all the bits and can feel them fill in the seat of my pants. Seriously , up another pound too on an empty colon and stomache… get my drift.
No post workout pain…kick those arthritic senescent cells to the curb.
I did not video because I didn’t see any staff, just medical students . Didn’t want to be creepy.
With staff is fine… students too…but paid to work. Hahaha
What are the inputs and assumptions AI used to compute these values? If I take my DeXA lean mass value and multiply it by AI’s “realistic” monthly gain in muscle mass, I get 124 lbs x .35% = .43 lbs per month gain for a guy that’s 5’ 7". Not nothing, but not that impressive.
I guess it depends on expectations a person has but gaining .43Lbs of lean muscle in one month by taking a pill and doing nothing else for it, to me sounds huge. Assuming the rate continues for a while (I have to assume it will subside at some point) say 12 months that would translate into about 5-6 lbs of lean muscle. I would be very happy if it were only 2 lbs, and extremely happy with 3-4 lbs.
These analysis tend to be quite lengthy, so I typically only post the summary. Here’s a synopsis of the factors considered: Translation Factors: Mouse to Human
Factor 1: Time Course Adjustment
Mouse treatment duration: 3 months Mouse lifespan: ~24-30 months Human equivalent by multiple methods:
Scaling Method
Mouse 3 Months → Human
Lifespan proportion (3/24 × 80)
~10 years
Metabolic scaling (mass^0.25)
~22 months
Protein turnover (7-10×)
~21-30 months
Empirical muscle adaptation (6-8×)
~18-24 months
Consensus: 3 months in aged mice ≈ 1.5-2.5 years in aged humans
Time scaling factor: 6-10×
Factor 2: Effect Magnitude Adjustment
Historical translation rates for muscle/body composition endpoints across drug classes:
Intervention
Mouse Effect
Human Effect
Translation Rate
Testosterone replacement
+15-20%
+5-8%
30-50%
Myostatin antibodies
+20-40%
+3-8%
15-25%
Resistance exercise
+15-25%
+5-10%
30-50%
Senolytics (D+Q, preliminary)
+15-25%
TBD
Est. 25-40%
GH/IGF-1
+10-20%
+2-5%
15-30%
Average translation rate for muscle mass: ~25-40%Average translation rate for functional outcomes: ~30-50%
Factor 3: Variability Adjustment
Mouse studies use inbred strains (identical genetics)
Human populations are heterogeneous
Expected SD increase in humans: 1.5-2.0×
This affects statistical power, not expected mean effect
I took maraviroc for a decently long time because of Dr. Patterson’s group’s research. It seemed to be mildly effective for inflammatory issues. 300mg twice a day for some months. Eventually my liver enzymes were elevated so I went off of it. Likely related.
at the gym.
, up another pound too on an empty colon and stomache… get my drift.
. Didn’t want to be creepy.