Yes, I think I am a good candidate to see if Maraviroc helps, as I am pretty shredded and stable in my workout routine and ability… with over one year of no improvements. I am ready to move up.
We are fortunate to have the best in longevity research… and honesty… as a frequent flyer on this excellent site - Dr. Matt Kaeberlein. I private messaged him for his thought on Maraviroc.
My message:
Matt we have been corresponding for 4 years. I have learned a lot from you and Dr. Peter Attia over the years.
I am feeling like I am decades younger. And, blood panels, physical ability and biological markers indicate I am functioning at a much younger age level than my chronological age. Thanks.
I am curious about your take on the medication Maraviroc that is reported to increase both Muscle Mass 28% and Endurance 20% Could be a great topic for Optispan.
More episodes of the podcast coming soon, I promise. It’s great to have many interesting projects at the same time, but only so many hours in a day. Re: Maraviroc, I agree that mouse study is pretty interesting.
My gut reaction is that it’s probably a real effect, although magnitude might be overstated even in mice.
We’ll see how well it replicates.
Intriguing to think it might do the same in people.
If the effect size were similar, I’d guess we’d already know since hundreds of thousands of HIV patients have taken it for many years at doses that ought to be comparable.
Could be hard to tell in that population though.
Side effect profile doesn’t seem terrible.
Given some of the far more wacky stuff people are trying out there, I’m guessing we’ll get some first hand reports here pretty quick from biohackers who see this paper and decide to go for it.
Because you’re in better shape than most, I wonder if the effects would be as noticeable, if at all, as opposed to someone with moderate or advanced sarcopenia. (?)
Hard to say Phillipe,
Having little adipose tissue (fat) and being very toned from years of working out . Definitely think TRT and the rapamycin have helped me keep trim inspite of my voracious appetite.
Constantly hungry… on a seafood diet… I see food and I eat it… dad joke. I do eat constantly. And weight doesn’t fluctuate 188 - 190 past 3 years.
Maybe it helps in a faster manner as I am in fairly good shape. Same goes for the rapamycin - I seem to be a super responder, or maybe just lack the obstructions or crap in my system that lets it work well. Inflammation of a 40 year old… outdoor allergies gone… memory fantastic, skin quality great… and much more.
Took my 75 mg dose with my nightly supplements and had listless sleep. And, crazy horny. Will see if this persists. I am not complaining… yet. Hahaha .
Might switch to morning dose of Maraviroc after my coffee (Taurine, Creatine and Collagen).
Took my 75 mg Maraviroc this morning… lots of energy, and libido too… got a bit of tinnitus. Something I usually get for a few days post rapamycin dose. Hmmm.
Hey John… yes. I am on Jardiance for about 4 months 25 mg daily.
Fantastic for my B/P and blood markers. Really knocks out sugar and salt… which I eat a lot of in my diet. Urine stream full and frothy… was told it’s the salt.
Jardiance (empagliflozin) is a SGLT2 inhibitor drug that helps treat type 2 diabetes, heart failure, and chronic kidney disease by making the kidneys remove excess sugar through urine, improving glycemic control and reducing cardiovascular/kidney risks
Rapa, empagliflozin, and maraviroc is hands-down the most intriguing three-drug combo i’ve seen anyone using. Following your results and very curious to see how things progress
Increased my reps on each set by 5… my one hour 15 minutes workout grew about 15 minutes… but was no issue.
Ultimately, increase workout sets by 10. Then, in a few months increase weights by 10 pounds… go back to original repetition numbers with heavier lifts.
Systemic physiological aging is largely driven by disrupted metabolic homeostasis, yet the central mechanisms of this metabolic dysfunction remain poorly defined. Here, we identify the hypothalamus as a critical hub driving systemic aging through neuroimmune-mediated mechanisms. Single-cell transcriptomic and immunohistochemical analyses revealed that aged hypothalami exhibit significant infiltration of CD8⁺ T lymphocytes, beginning in middle age, with signatures of activation and tissue residency. These T cells intimately interact with tanycytes and microglia, promoting neuroinflammation and progressive tanycyte loss, a defining hallmark of hypothalamic aging. T cell receptor profiling revealed a substantial presence of invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells, likely activated through cytokine-driven, antigen-independent mechanisms. In aged hypothalamus, microglia secrete chemokines CCL3 and CCL4, whose ectopic expression in young mice was sufficient to trigger persistent hypothalamic T cell infiltration and accelerated systemic aging. Circulating oxidized LDLs (OxLDLs) were identified as upstream inducers of this chemokine response. Notably, pharmacological blockade of the CCL3/4-CCR5 axis with Maraviroc and Cenicriviroc prevented T cell recruitment and ameliorated metabolic and physiological impairments. Given the clinical safety of CCR5 antagonists and individuals lacking functional CCR5 remain generally healthy throughout life, our findings highlight midlife CCL3/4-CCR5 inhibition as a translatable therapeutic target for delaying age-related decline and promoting healthspan.
At the gym last night added 10 more reps to all my sets… instead of 30 reps in a set… now hitting 40. Wasn’t too bad… I did not hit failure… even on pull-ups. It did really extended my time in gym by 30 more minutes. Took 1 hour and 45 minutes to complete. No issues this morning despite extra work out… no pain… or stiffness.
Biceps and chest are feeling very firm/hard. My weight is up 2 pounds this morning at 193 pounds… so maybe it is working. Won’t give a full report until 3 full months of dosing.
Relevant to the previous study, there’s also an association between CCL3-enriched inflammatory microglia and aging across the primate brain:
Aging in macaques is associated with substantial shifts in microglial subcluster abundance. Migratory microglia (subcluster 5, ENPEP+ SEMA6A+) declined with age, while neuroinflammation-associated microglia (subcluster 4, GLDN+ RASAL2+) increased with age. These shifts occurred across nearly all brain regions, with the cerebellum as the sole exception (Fig. 3H; Fig. S6A). Microglia subcluster 4 is enriched for proinflammatory cytokine response genes (CCL3, IL1B, CD83, SPP1, LPL, ITGAX) typically upregulated in response to amyloid β pathology (33) (Fig. S6F), suggesting convergence between aging-related inflammation and inflammatory responses in AD. We observed regional variation in age-associated abundance differences, with microglia subcluster 4 in dlPFC, M1, and EC showing the largest increases, while border-associated macrophages (microglia subcluster 7) were regionally restricted but displayed significant age-related increases in the ACC and NAc (Table S7; Fig. S6A).
There’s a massive plasma proteomics study that was just released on bioRxiv which estimated the biological age of more than 40 cell types using plasma proteins. Of any cell type, aging of skeletal muscle myocytes was the second strongest predictor of all-cause mortality over 15 year follow up (HR 4.18). Number 1 was “muscle cells” with HR of 4.38, which reflects a composite of muscle cell types across the body.
Certainly makes a strong argument for any drug which slows muscle aging.
. Definitely think TRT and the rapamycin have helped me keep trim inspite of my voracious appetite.
gone… memory fantastic, skin quality great… and much more.