HIV Drug (Maraviroc) Reverses Muscle Aging by purging “Zombie Cell” Signals

You asked about dosing… my conversation with my physician was… adjusting mouse studies translational to humans.

At 85 kilo, I can take the dose all at once 75mg then skip a day… so every other day.

Or split pill take 32 mg per day.

We discused the various pill options.

As it is not the 300 mg daily x 2 so a total of 600 mg which is the HIV dose, 33 mg… 1/20th no anticipated issues. But, we will monitor.

Going to try it for 3 months then see my physician, decide what steps … or adjustments at that point.

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Thanks. Keep us updated.

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I bought a bottle. I’m thinking don’t do it for a few days after Rapa. Was there any talk about that at all?

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Thanks Phred…

Yes, makes perfect sense… like staggering TRT with rapamycin. Should have in the next day or two.

Appreciate the heads up buddy.

I assume you mean on a pec deck machine? That’s impressive.

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Is he a telemarketing doc? Can you share his contact info if he’s accepting new patients?

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Yes, hahaha - I guess its a Deck- Pec - I can do 190 lbs 30 reps in a set. The medical students call it the chest/fly machine. Been stuck at 190 lbs for a year or two. I weigh about 190 right now. If I go up to 200 lbs with no stress - for me that would be a significant improvement.
Pec Deck Fly Overview | Proper Form & Tips & Benefits

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As you might guess, he is booked solid. He has 3 offices in the area - all rural Missouri - Unfortunately, he doesn’t do telemarketing. Younger progressive doctor. My visit yesterday, he old me his personal practice will be focusing more on weight loss and hormone therapy, but I will still get total care.

Very focused on shared research and worked with me. Has been a freind for 20 years and my physician for the last 6 years – approved me to go on TRT, Rapamycin, HGH and Empaglizozin SGLT-2 Jardiance and now Maraviroc.

He just took over my Finasteride and Tadalafil prescriptions from my Urologist who is no longer seeing patients due to his own health issues. My PSA is under 1 … at .9 didn’t really need a urologist. I just liked it – and insurance covered the extra physician.

Very lucky to have this guy.

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Amazing. Ask him about switching you to Dutasteride. Less potential side effects (google “finasteride syndrome”)

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Post-finasteride syndrome is not a real condition. Moreover, dutasteride is a more potent inhibitor of 5ar type 2 compared to finasteride and strongly inhibits 5ar type 1 while finasteride only binds very weakly and reversibly to it. On top of that, finasteride has a half life of 6 hours, totally leaves your tissue within two weeks and from all the rcts and case studies we have, side effects totally disappear within 1-3 months. Dutasteride, on the other hand, has a half life of 5 weeks and can potentially stay in your system for 6-12 months after cessation.
The only reason less mentally ill men claim they got persistent side effects from dutasteride is simply because far less men are on it than on finasteride. But there certainly are forum anecdotes for persistent dutasteride side effects.

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The translational protocol you quote is errorenous. AI made a major mistake and didn’t account for species differences in receptor affinity nor differences in delivery method. A proper translational calculation shows 37mg every two weeks is the human equivalent to the dosing the mice received.

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I am probably a bit unique on this forum as a proscar/finasteride user for 34 or 35 years. Started to keep my hair. :laughing: It worked.

My physician and I actually discussed this as I requested he continue my urologist’s prescription and we decided to stay the course with finasteride.

Benefits: Walnut sized prostate, kept my hair… no ED issues… wake to morning wood. And, new research says it clears cholesterol from the blood.

Appreciate your heads up.

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Thanks for this… even 32 mg is 1/20th of an HIV user daily dose.

Might start higher and just see. Will review all markers in 3 - 4 months.

Definitely will keep your protocol on my back burner. Appreciate the message.

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So did your doctor make that dosing recommendation (75mg every other day) based on this thread (that you shared with him) or on his own research?

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Combo - based on his familarity with the drug from HIV infected patients on treatment. We discussed trial and if anything is an issue - immediatley get in touch with him. Was the same for starting rapamycin as an early adopter. We selected a 3-month visit plan and daily outreach if any issues arose. Nothing ever happened. But, back then it was even more experiemental - with a dosing plan 6-8 mg weekly.

He perused a few articles on Maraviroc and the one posted by RapAdmin with the translational information during our visit - we spent over an hour chatting on everything longevity as it pertains to my protocol. Pretty typical visit because he is fascinated by my progress and benefits. Calls me a medical case study in improvement and longevity. He is about 46 years old. So, maybe preparing for his future too.

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