Got it. Clear now. Great to hear you’re making progress.
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Just to update everyone the Tinnitus has returned as usual, and it appears it had nothing to do with Maraviroc (been on it for two months now). It must have been something else/unknown. It does at times subside a bit (on its own) or perhaps a result of some unknown event but wanted to let everyone know that maraviroc does not seem to effect tinnitus either way (good or bad).
As an FYI I’m still using maraviroc and do like the effect of it.
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I have mild to moderate tinnitus. There is nothing that I have ever tried that has had any effect.
But what you describe is common and puzzling to me. If there is no cure, why does my tinnitus vary so wildly. It often almost completely disappears only to return at full force.
From my own research I find it obvious that very little is known about it as to cause, effect, or cures.
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Buy a dynamometer for $25 on Amazon. You will only have to tolerate 2 seconds of pain to test your grip strength.
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Yes we all have the same experience. On full force, then goes away mostly for no reason. But there is one drug, Colchicine cuts it about in half. I wasn’t sure at first, but I’ve been off and on a few times now and the difference is very noticeable. I’m still not sure about this one. That’s why I take it off and on.
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@Bicep Can you clarify the part you are not sure of. Is it in general you are not sure about Colchicine, or you are not sure if Colchicine is helping with tinnitus or not? And @desertshores have you ever tried colchicine yourself?
I’m sure it helps tinnitis, but is not a cure since it comes back when you quit taking it.
I’m not sure I want to poison my microtubules. They’re kind of a magic thing and seem like they could be important. I don’t notice anything different from taking the drug besides the tinnitis. It greatly reduces the chance of stroke and I don’t want a stroke. So I take it off and on and when it’s gone I probably won’t get more.
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No, because it has too many possible side effects.
And, " * Narrow Therapeutic Index: The difference between a safe dose and a toxic one is small. Overdose can be fatal and requires immediate medical attention.
There is currently no quality clinical evidence to suggest that colchicine can cure or reduce tinnitus.
So, I’ll pass on this intervention.
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I think grip strength is mostly about the strength of the forearm muscles, not how much pressure you can tolerate on your palms or finger pads. Some, like Peter Attia, speculate that grip strength is a proxy for overall body strength because it develops when you lift weights or have a lifestyle that engages with heavy stuff. All the research I’ve read on the topic has been correlational, so I tend to agree with Attia. You might want to consider padded gym gloves to make things more comfortable. I find those help. Some of us lose fat pads in the hands and feet as we age, so that could be a factor in comfort.
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That makes a lot of sense! Yeah, even when doing a bench press, while I can press a lot of weight relative to my size, the weight of the bar on my bony little fingers is deathly! I’ll look for a pair of gloves. It takes a village!
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Wow, I learned something new “Narrow therapeutic Index” and a very important one to be aware of. From now on, you are my favorite doc LOL. Thank you. Out of curiosity, are you aware of any of the common drugs we are taking that fit this category? I know Rapa is not and some of the lipid and glucose lowering ones are not either, but maybe some of less common ones we discuss in these boards, i.e Dayvigo, Selegiline, captopril etc…
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This is not medical advice, and some of these drugs or supplements I have taken or am taking.
The following is taken from a ChatGPT 5 query, and I am sure actual doctors who are members of the forum would have more insight
Summary
The drugs with the greatest danger due to narrow therapeutic range or severe toxicity in longevity communities are:
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Colchicine
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Dasatinib
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Navitoclax
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Digoxin
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Lithium (at pharmacologic doses)
“These drugs can produce life-threatening toxicity with small dosing errors or interactions, making them the most hazardous compounds commonly discussed in longevity forums”
As I recall, someone in another thread said something like, “We must be careful not to off ourselves in the pursuit of longevity.”
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Calling all Maraviroc users!!!
I got my maraviroc and I excitedly took 1/4 of a pill yesterday…. I was expecting to be sharp as a tack and feeling bionic… nope, nothing, nadda!!!
I said to myself ‘I guess you need to actually be doing something to feel stronger’.
So, I took another 1/4 this morning because it’s my resistance training day…. Nope, nothing, nadda… it was as hard and as miserable as it always is!
Thoughts?
@Agetron @ageless64 @Kelman anyone else?
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Keep taking it for a good month or so and you should see marginal results. For me it was really good and helped a lot, but my case was unique because I lost a lot of muscle and with that, I became very weak (one year on GLP1). After couple months of using maraviroc, I was back to my normal self. My strength and energy are back to where I was before GLP1 so I’m very happy with it. But, for you or people that are already in good shape and strong I don’t think you’ll notice much difference especially early on. I intend to keep using it but I’m doing every other day now 37.5mg. As far as memory goes hard to tell but I doubt you’ll notice anything, I definitely can’t say my memory improved much, if it did it’s not easily noticeable, but my memory is relatively ok to start with, so I doubt I’d see a difference even if it helps/helped.
I see it as something that in most likelihood helps preserve muscle and strength long term as opposed to yielding immediate results (for most people) and that is excellent for our age bracket because as we age, we tend to get weaker and weaker and anything that helps would be greatly appreciated. I bought a supply of about 5 years every other day 37.5mg so I intend to keep taking it. I’ll update this post then LOL
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Have not gotten mine yet. First time ever my order was seized at the border.
Go to failure. You don’t know if it’s better unless you’re going as hard as you can.
I’ll be really disappointed if it does nothing. Thought I was going to be automatically buff!
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Thoughts?
Ummm give it some time to build up maybe? Lol… its not exactly cocaine with instant results.
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Ok, so I just got back from my getting my yearly Body Spec dexa and I’m a little postal right now… says I lost 1.2 of muscle.
So, back to Maraviroc …
2 questions:
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I was going to err on the side of caution and only take 1/4 pill 2x per week. Does it make sense to take it on training days, or does it not matter?
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having said that, now that I’m feeling a little sad/desperate from this unexpected result (I’ve gained so much strength this year, more than any other year, so this was like a knife through the heart!), I’m thinking I should consider taking it more often, but I also don’t want to do anything that might hurt my health.
Aside from checking labs to make sure there is no negative effect to my liver, is there anything else anyone knows I should worry about? Is this simply still too new to take it more often if I want to avoid taking too much risk?
I’ll have a nice long chat with Claude about it, too!
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Thanks for the update. I don’t know your other dexa scans, but if you lost more fat than the 1.2 of muscle(lbs I’m guessing) on your total body weight, then it’s not too bad.
Give the Maraviroc a fair trial, and adjust the dosages if you need to.
If you don’t get the results you are looking for, you could consider trying Rx medicines for muscle growth next if you have never tried any before such as testosterone and/or nandrolone - both those come in various forms as well.
I think those might be the safest bioidentical hormones for men and women to use for replacement therapy, but I am not 100% sure.
Not sure if you have had your testosterone or igf1 levels tested, but you could consider testing those if you have not.
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Quit the GLP1 obviously.
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Were you taking any GLP1’s during this time? If so dump it. As for Maraviroc one needs to exercise caution (obviously) but it is tolerated ok by the aids crowd taken in much higher doses and at more frequent intervals, so depending on the need (i.e. to build muscle) I would say even daily is ok (at a low dose). I would however start initially very low dose i.e. 17.5 mg or 37mg for a week or so, then move on to higher doses if desired/needed.
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