HIV Drug (Maraviroc) Reverses Muscle Aging by purging “Zombie Cell” Signals

Thanks, I thought you do Glynac, Creatine and Taurine (and any other supplements) daily also?

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Yes, 5 grams Taurine and 5 grams Creatine in coffee everyday.

Not wanting to bore anyone.
Currently I am doing the following prescriptions
Physician supervision.

Weekly:

Rapamycin - Zydus 6 mg straight. No GFJ.
TRT - Cypionate 200 mg 1 ml, thigh injection
Doxycycline 200 mg

Every day medications:

HGH - meditrope blacktops 3.3 iu butt injection
Proscar - finasteride 5 mg
Cialis - tadalafil 5 mg
Minoxidil 5 mg
‐—‐‐-------------------------------------------------------------
Every day over the counter supplements:

Taurine BulkSupplements 1 teaspoon in coffee
Creatine Monohydrate 1 teaspoon in coffee

Lecithin Sunflower Carlyle 2400 mg (healthy sperm loads seriously) 2 capsules

DHEA Wal-Mart 100 mg
Vitamin D3 Spring Valley 4,000 iu
Zinc 22 mg
Lithium Orotate Horbaach 10 mg
Melatonin 30 mg
Magnesium Nature made 200 mg
Boron Horbaach 6 mg
Quercetin bromelain Luma 500 mg
Omega 3 Carlsons 1,600 mg
Astaxanthin Naturebell 24 mg
B12 Spring Valley 5,000 mcg
Vitamin C 1000 mg
K2 Spring Valley 200 mcg
Vitamin E Nature made 500 mg
NAC 600 mg

That is it.

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The most interesting man in the world.

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Congrats on the reduced Glycan Age! Curious if you have a DNAm PhenoAge?

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Curious if you have a DNAm PhenoAge?

No

Not opposed… just haven’t been introduced.

What’s your dosing schedule for Maraviroc? I’m interested in it for my dad.

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I was curious because I have done both and had dramatically different results (over 20 years). https://www.longevity-tools.com/. This site has the phenoage calculator, but has also recently added some detailed interpreters - glucose metabolism, iron status and liver function, with more to come. All based on blood work. Pretty neat!

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My prescription is 150 mg pills… I cut in half and take a half, 75 mg - every other day.

Starting my second month dose. I think it’s going well. No side effects.

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Here is my GlycanAge graph of my test for inflammation over the past 4 years. Except for a big bump over a 7 month period, when I was high dosing rapamycin on a weekly schedule… (likely shutting down MTOR 1 almost completely, more rapamycin is not better…), I have maintained a 22 year difference between my biological age and chronological age. When I asked in their Glycan Age patient profile how many tested match my scores… the answer is none. I am a fraction… of a fraction. I am probably the only user of rapamycin at my age as an early adopter.

You can see that primarily using rapamycin I have managed to keep my sterile inflammation levels low, which is the driver of aging and chronic diseases.

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I can’t remember who it was, but someone here posted his liver enzymes went up on a low dose… so if your dad starts it, just make sure he does labs.

I’m going to start with 1/4 pill 2x per week and plan to get new labs after 30 days.

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Scientists discover how muscle stem cells “flip a switch” to rebuild damaged muscle

Scientists discover how muscle stem cells “flip a switch” to rebuild damaged muscle Scientists discover how muscle stem cells "flip a switch" to rebuild damaged muscle

When PFKM returns, muscle building begins.

Getting a better handle on muscle loss and rebuilding.

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Jagdish carries it now, btw. $128 for 150mg 60 tablets.

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Does Maraviroc mechanism of action effect PFKM or anything else for that matter?

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Not sure… hope someone on here with more biological expertise can explain.

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Looks good….maybe Glycine 3 grams before bed(stacks nicely w/NAC)

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Hey Jim,

I take 75 mg… 1/2 of a 150 mg tablet every other day.

That is take one half in the morning (tends to keep me awake if taken at night)… skip dose next day… then take again. Since I take my Maraviroc regularly…I don’t coordinate my Maraviroc with my rapamycin dose.

However, I do take my TRT 200 mg …1 ml weekly injection. … 4 days post rapamycin. Keeping those opposite each other.

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Thank you! Good to know.

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In prepping for my Maraviroc trial (it arrives Monday!), my PT had me do the hang test for the first time in perhaps a year. (I rarely do it because I loathe it with a passion because it hurts my delicate little hands :slight_smile:

I am significantly stronger than I was a year ago, by a million miles. He expected my hang time to have increased too, but alas, it was even worse… I let go because it just hurts too much and I want it to stop, and not because my hands ‘can’t’ hold on any longer. The distinction of this is blurry because I feel I can’t.

Because grip strength is such an important longevity indicator, how do I look at the fact that I have almost zilch. If it’s pain vs strength related, does that make a difference, or it’s all the same and I just need to try harder and harder?

And while I’m at it, how do you look at muscle vs strength for long term aging? I realize there is some overlap of course.

I will get my annual dexa next week and will have more data, but even though I’m significantly stronger and constantly make new gains, I don’t know that I have bigger muscles.

Because I continue to make new gains, I’m not sure how I’ll be able to tease out what is normal or maraviroc, fyi.

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Maybe I am not understanding you correctly, but the hang test would actually be a good measure of strength meaning it tells you how long your muscles (in your hands/arms) will be able to support your weight. The stronger you are the more time you’ll be hanging on. So, not exactly sure where the confusion is. I usually measure it on machines. For example, if I do a daily exercise on a certain machine and normal daily weight on that machine is 50lbs for the three sets I do daily then if I start Maraviroc and couple weeks later I can easily add 20lbs to the 50lbs i usually do that means Maraviroc is making me stronger.

The weird or maybe funny part is I can definitely attest to Maraviroc making me stronger but Only on the days I take it. I take it every other day, and, on the day I take it, I can definitely do about 20% heavier weights but if I don’t take Mara for couple days, I’m back at baseline weights. So not 100% sure what to think of it. Obviously, it does seem to positively affect muscles and strength but not exactly easy to measure the effects on consistent basis. What I can easily notice is the fact that I have more endurance (way past the placebo effect) on the days I take it. I hate exercising naturally (and this was exacerbated even further by doing GLP1’s for past year) and on days I take Maraviroc I have no problem exercising and tend to get less tired. So, it seems like an interesting drug/substance, and I intend to keep taking (perhaps one month on, one off after a year or so of continues use) unless it messes up any of my biomarkers which I have not checked yet but intend to do so in a month or two. My positive results may be somewhat distorted by the fact that I was really beaten down by Tirze/Reta which made me very weak and tired, so Maraviroc has helped me tremendously. I’m not so certain someone that is already at their best or close to it will feel any stronger, especially as fast as I did. In my case within three days of using it (initially daily, and now every other day) I could see myself getting stronger. But definitely a very interesting find as there aren’t many substances out there that I know of that would have such a fast and profound effect on strength (recovering strength in my case) except the steroids which I would not want to try.

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Great feedback! I’ll make sure to take it the morning before resistance training to see what happens.

I meant to say…
I am getting stronger all the time… I have not plateaued yet. I have had 2 new PRs in my bench press in just one month… so if I get a new one, will that be from Maraviroc or was it going to happen anyway.

But, now that you’ve shared this, it seems it might be obvious… that I’ll hit a PR, but then the next time I might not be able to move the same weight.

On the hang time for my grip strength….
while I am a ton stronger, my hands hurt when I hang, so I let go… so technically my hang time and grip strength have not improved…in fact, my time was worse… It is what it is, but it’s confusing because I expected to see stronger hands, so it was a little deflating.

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