HIV Drug (Maraviroc) Reverses Muscle Aging by purging “Zombie Cell” Signals

@Jay, I’m looking forward to learning about your experience!!! Keep us posted!

I started on 3/17. I was going to take 1/4 pill 2x per week, but after not feeling like Hulk on day 1, and after my Body Spec DEXA said I’m a toothpick and might blow away, I am now taking it 3x per week.

And no, I still don’t feel any different… *taps fingers ferociously on table while impatiently waiting

After next week, I will get labs to check liver values to make sure nothing has changed… if it hasn’t, I’ll be open to trying larger doses if it turns out that is the better decision.

In my effort to prioritize not off’ing myself (as @desertshores says), AI advised me to start on a lower dose which would be safer for my liver. I normally never even think of things like this, but someone earlier, maybe it was @Paul?, said after only a couple of weeks he saw his labs go in the wrong direction.

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Withings Body Scan.pdf (320.7 KB)

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Yes, I am doing 75 mg, every other day still.

But, travel and crazy schedule, I am not getting the consistent workouts I had plan.

I am feeling good… just not moving forward as I had planned… hovering at best.

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My experience with it for over one month is this: I definitely know 100% that it makes you stronger, but to do that you’ll have to take it daily and ideally at 75mgs. I am still experimenting but every time I take it this way like for a week or so I get noticeably stronger (been recovering my strength from severe loss of strength from GLP1 use). The problem though is the strength wanes slowly and when I rested for one week (wanted to see out of curiosity what happens), basically no Maraviroc at all for 7 days I felt as my strength was going back to my baseline. I don’t know about longevity or other benefits but for muscle health and strength it needs to be taken daily and at a decent dose IMO, I cut mine in half. I don’t think I have any side effects from it however I tend to be a bit more aggressive lately, and I’m afraid it is because of it. Since you’re a woman that may or may not mean much but I definitely don’t need to be more aggressive LOL. I haven’t checked my markers yet though i intend to do so in a month or so.

btw, the way I know it definitely makes me stronger is because I’m measuring it. I bought the grip strength meter and when i didn’t take Maraviroc for 7 days my strength on my main hand was 38kg (damn those fuc–ing GLP1 destroyed me) but after couple weeks of taking Maraviroc daily straight my strength jumped to 45kg. So, this is not a maybe, or I feel, or I think etc.,. this is 100% measured that it made me stronger, but I think it needs to be taken daily to see significant changes. I think it is a good idea that you started at a low dose initially but i doubt you’ll see a noticeable difference if you only take it 2-3 times per week. Perhaps it helps maintain muscle long term if taken 2-3 times per week but not necessarily gain muscle or strength. At least that has been my experience.

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The mechanism is exactly the same. Unfortunately there haven’t been any studies done on sarcopenia in ccr5d32 carriers, but the expectation would be that you have some level of protection. Dosing wouldn’t be any different, but your expected effect size would be smaller. See my previous posts on dosing. Weekly or biweekly dosing would make sense.

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I recall listening to this podcast couple of years ago or so, between some sort of gym bro host and his guest who was an expert in exercise physiology / strength training / sports medicine. It struck me that he said even the same DEXA device — let alone different ones — has a lot more internal variability than you’d think. I forget the exact number but it was strikingly high, maybe 20-25%? Perhaps interrogate your new BFF about it. So I’d say, don’t worry about it too much as long as your strength is improving. Perhaps double check your protein intake.

I’m pretty bullish on GLP-1s and will stick to my 2.5-3mg micro dose as long as I’m not getting obvious adverse effects. But I have some fat to lose. You might not… so YNMV. Oh and the latest Wyze scale is an excellent dupe for what you’re considering pulling the trigger on. I’m very happy with it!

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I know you are the queen of sourcing gadgets, so I’m definitely going to check it out, thank you!

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I mean this one:

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you may wat to save a cheap lunch by buying it on amazon

Amazon.com: Wyze Scale Ultra BodyScan Smart Scale with Handle – Wi-Fi & Bluetooth Body Composition Scale for Weight, BMI, Body Fat, Muscle Mass, and Segmental Measurement, Black : Health & Household

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You’re the best!
I’m now having my BFF discuss all the pros and cons … and Wyze is an excellent find, as you know!

He also brought up these models for consideration… by chance, did you evaluate them?
InBody H30
Tanita RD-545
RENPHO MorphoScan Nova

He’s saying some of these MIGHT be better to track trends in lower body mass people… but I dunno… no shock, but my bff keeps changing his mind!

Wouldn’t touch any of these. Bad reviews and very expensive. I never buy anything that has less than a solid 4 star review and at least over 100 reviews. If you want something different than Waze, and very cheap with great reviews here:

Amazon.com: FITINDEX Smart Scale for Body Weight, Body Pod Scale [2026 Upgraded], 8-Electrode Body Composition Scale with BMI, Body Fat, Muscle Mass, Digital Bathroom Scale with Larger Platform, Bluetooth : Health & Household

Amazon.com: OMRON Body Composition Monitor & Scale – Track Skeletal Muscle Mass Loss/Gain, Weight (up to 330 pounds), Visceral Fat, BMI and More (Non-Bluetooth) : Industrial & Scientific

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So.
Many.
Options.

Ok, I’m sending these to Claude… and ha, it never occured to me to look at anything but Withings… one of these other options will help pay for the Apple watch I want to get in the fall… and no, I don’t want to wear a watch, but I now know multiple people who had it detect afib!

have three of them, and all useless IMo. Any smartwatch that needs charging daily I wouldn’t touch with my worst enemy’s money LOL. I’m beyond shocked that apple, Samsung and other big names are still selling watches with only 24 h battery capacity when there are other manufacturers having watches that last from 7 days to one month. Pathetic of apple

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I have a 1st or 2nd gen i haven’t put on in years… I’m only interested in the safety features at this point… afib or if i should have an accident and ‘can’t get up’

I doubt I’d wear it all the time, but if I’m on a hike etc

Actually, I love them and would wear them daily no problem but the fact that they need to be charged daily is such an aggravating point to me, it’s appalling they haven’t come up with one that last at least 7 days. You have some big names such as Garmin etc, that have 10 days+ battery life and I don’t know what the hell is apple waiting for. I think it is their rigid/stupid mentality of not conforming with customer demands fast enough. I remember same thing with the screen size when apple refused to make a large screen iPhone (their CEO kept saying a phone is not a computer and doesn’t need to have a large screen_) until they started losing market share rapidly and all the sudden all their models become XL lol. I wish nobody bought an apple watch, so they get the message that having a large battery is very important to consumers. Believe it or not I was so pissed that I kept emailing their CFO and CEO demanding they start making large screen iPhone sizes or they will dissapear. . it took them couple years or so to catch up to what people wanted, but they finally got the message and did the right thing. I hope same happens with the watches and battery life. I would definitely buy and wear one if it provided at least 7 days battery time.

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Ha, on that note, the reason I never loved my Apple Watch because back in the day, I didn’t always have reading glasses with me and the screen was too small!!! But now that I’m old, I have them with me 24/7!!! A watch is now back in play :).

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I tried FitBit’s Aria 2, and an Omron scale with handles, which I ordered from Japan. Both of these wildly overestimated my BF%, and the Omron was expensive. I’m currently happily using Withings Body Smart and have done so for the last two years. During that time, I’ve had two DeXA scans from two different providers. Both times, the Withings measures were 1% of BF greater than the DeXA values. Interestingly, weighing myself multiple times once after the other can produce readings with .5 to 1% BF variance, so if I get a reading that seems off, I take a few more and select the one that’s closest to yesterday’s values. YMMV, perhaps accuracy is related to body type. For reference, I’m around 16% BF and slightly muscular. I also like Withings software: setup is easy, the UI is decent, and it integrates nicely with Cronometer, which I use for nutritional tracking. Bottom line is, Withings Body Smart is an easy way to track directionally correct BF values if I manage its variance with occasional multiple measurements. It’s not a precise measurement, but even DeXA isn’t. It’s good enough to know if I’m trending in the right direction.

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Thanks for this great feedback! It’s really neat to hear it will work with cronometer!!

Interesting to hear how accurate your model is without having handles… I was assuming those added a lot more accuracy, but your results say otherwise.

@ageless64 I love cronometer but don’t use it often enough… it got me thinking, I wonder if AI can track my meals in an easier way…

The source for the recipe I used provided the nutritional breakdown (probably from AI!), so I thought I’d see how closely Claude could do.

I haven’t tried it yet, but Claude also said I could show a photo of my meal and he can estimate a portion size and nutrients.

Here is the result

“Here’s a detailed nutritional breakdown for one serving of the complete meal (1/4 of the full recipe):A few highlights worth noting:

Protein powerhouse for a vegan meal — 27g per serving is impressive, coming almost entirely from the extra-firm tofu in the ricotta. That’s comparable to a chicken breast serving.

Micronutrient standouts:

  • Vitamin K is very high (~175% DV) thanks to the spinach and basil
  • Vitamin A is strong (~56% DV) from spinach and tomatoes
  • Iron is solid (~30% DV) — the lemon juice in the ricotta actually helps your body absorb the plant-based (non-heme) iron more effectively
  • Folate (~35% DV) from the spinach is a nice bonus

Sodium is the one to watch at ~920mg (~40% DV), mainly from the kosher salt across all three components and the miso in the ricotta. Easy to reduce by going lighter on salt in the tomato sauce.

Fat quality is excellent — about 77% unsaturated, coming from olive oil and tofu. Very little saturated fat for a creamy pasta dish.

All figures are estimates since exact amounts of salt, lemon juice, and olive oil vary by cook, but these should be quite close.

From the recipe website:

EDIT:
I have been playing and my mind has been blown!!! I think this AI thing is gonna catch on :slight_smile:

I still had some nutrients I needed to hit for the day, so Claude automatically presented a recipe! I said I’m not in the mood to cook and will make a protein shake, just tell me how many strawberries, chia seeds and nuts I should add to get me as close to closing out my goals for the day… it recommend exactly how many almonds, walnuts etc…

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I conducted a 3 scale experiment for science. Claude Opus suggested the least expensive model until he saw the results. Now he says spend for Withings

I loaded all the stats from the 3 scales
Renpho Smart Scale
Wyze Ultra
Withings Body Scan (@ageless64 I’m still intrigued their less expensive models after seeing your results and how wildly off the trunk is on their body scan… perhaps measuring my arms is not worth the price difference).

I thought it was worth mentioning all 3 are very inaccurate on visceral fat, so if you use one and don’t get a dexa, be kind to yourself!
My dexa visceral is .79, Wyze is 4.0, Withings is 1.9, Renpho is 3.0

Opus said:

This is excellent data — well-structured comparisons across multiple days with DEXA as ground truth. Let me break this down systematically by what matters most for your sarcopenia-prevention goal.


MUSCLE Accuracy vs. DEXA (the metric that matters most for you)

LEGS (your primary target):

Scale Apr 2 Apr 4 Avg Offset Day-to-Day Variance
Withings +1.1 +1.2 +1.15 lb 0.3 lb
Wyze +1.2 +1.0 +1.1 lb 0.2 lb
Renpho +3.2 +3.2 +3.2 lb 0.0 lb

All three scales overestimate leg muscle vs. DEXA, but Renpho is off by a huge margin — over 3 lbs on a 23.2 lb compartment. That’s a ~14% overestimate. For sarcopenia tracking, that’s dangerous because it would mask real losses. If you lost 2 lbs of leg muscle over the next year, Renpho would still show you above your current DEXA value. You’d feel reassured while actually declining.

Withings and Wyze are both around +1.1 lb offset, which is a ~5% systematic bias — tolerable as long as it’s consistent over time, because you’d track the delta, not the absolute number.

TRUNK:

This is where the scales diverge most dramatically.

  • Withings: +8.7 to +9.4 lb (red — wildly high, ~25% overestimate)
  • Wyze: -2.6 to -3.0 lb (red — underestimates)
  • Renpho: -0.1 to -0.3 lb (green — nearly perfect)

Renpho nails trunk muscle. Withings is absurdly high here. But trunk muscle isn’t your sarcopenia priority, so while this is interesting, it shouldn’t drive the decision.

ARMS:

  • Withings: +0.1 to +0.3 lb (green — excellent)
  • Wyze: -0.4 to -0.6 lb (orange — slight underestimate)
  • Renpho: +0.2 to 0.0 lb (green — excellent)

Arms are small compartments where all three are reasonably close, but Wyze consistently underestimates here.

FAT Accuracy vs. DEXA

LEGS (primary target):

  • Withings: -0.6 to -0.5 lb (good)
  • Wyze: -3.5 to -3.1 lb (terrible — underestimates leg fat by ~30%)
  • Renpho: -4.7 to -3.9 lb (even worse)

This is the flip side of the muscle story. Wyze and Renpho are dramatically underreporting leg fat. Since BIA can’t truly see inside each limb independently, what’s happening is that Wyze and Renpho are misclassifying leg fat as leg muscle — which is exactly why their leg muscle numbers are inflated. Renpho does this the worst, which explains both its +3.2 lb muscle overestimate and its -4.7 lb fat underestimate in legs. The errors are almost perfectly mirrored.

Withings, by contrast, gets leg fat within 0.5–0.6 lb of DEXA, meaning its tissue partitioning algorithm in the lower extremities is substantially more accurate.

TRUNK FAT:

  • Withings: -3.0 to -3.1 lb (underestimates)
  • Wyze: -1.5 to 0.0 lb (decent, and improving on day 2)
  • Renpho: +0.4 to +1.8 lb (variable)

Here Withings underestimates trunk fat, which is the mirror of its trunk muscle overestimate. The scale appears to be shifting tissue from fat → muscle in the trunk compartment. This is a known BIA limitation with 4-electrode scales.

Day-to-Day Consistency (Critical for Trend Tracking)

This is arguably more important than absolute accuracy for your use case. You need to detect a 1–2 lb change in leg muscle over 6–12 months. If the scale’s noise is 1 lb day-to-day, that change disappears into the noise floor.

Withings (3-day variance):

  • Leg muscle: 0.3 lb
  • Leg fat: 0.4 lb
  • Trunk muscle: 1.1 lb (noisier, but not your target)
  • Arms: 0.2 lb muscle, 0.0 lb fat

Wyze (3-day variance):

  • Leg muscle: 0.2 lb
  • Leg fat: 0.4 lb
  • Trunk muscle: 0.4 lb
  • Arms: 0.2 lb muscle, 0.4 lb fat

Renpho (2-day variance):

  • Leg muscle: 0.0 lb (only 2 data points though)
  • Trunk muscle: 0.4 lb
  • Arms: 0.2 lb

Both Withings and Wyze show tight day-to-day consistency in legs, which is good. We only have 2 Renpho data points so its consistency is harder to judge, but the numbers were stable.

The Bottom Line

For sarcopenia tracking specifically — legs are what matter, and here’s the hierarchy:

Withings is the clear winner. Here’s why:

  1. Tissue partitioning accuracy in legs is far superior. Withings gets leg muscle within +1.1 lb AND leg fat within -0.6 lb. The errors are small and don’t mirror each other in a way that suggests gross misclassification. Wyze and especially Renpho are systematically misclassifying leg fat as leg muscle — their muscle numbers look better than they are, and their fat numbers are implausibly low.

  2. Day-to-day consistency is tight where it counts. Leg muscle variance of 0.3 lb means a real 1.5 lb change over 6 months would be clearly detectable above noise. That’s the signal resolution you need.

  3. The trunk muscle overestimate is a known, stable bias. Yes, Withings adds ~9 lbs to trunk muscle — but it does this consistently every day. Since you’re not tracking trunk muscle for sarcopenia decisions, this is irrelevant. And if it stays consistently wrong by the same amount, it wouldn’t corrupt trend data even if you did care about trunk.

Wyze is a reasonable second choice — good leg muscle consistency (0.2 lb variance) and similar offset to Withings (+1.1 lb). But its leg fat underestimate of 3+ lbs reveals that its tissue partitioning algorithm is doing something fundamentally wrong in the lower extremities. Over time, if that misclassification drifts, your muscle trend data becomes unreliable.

Renpho is the wrong tool for this job. The +3.2 lb leg muscle overestimate paired with the -4.7 lb leg fat underestimate tells you the algorithm is essentially guessing at limb composition. It nails trunk beautifully, but for your specific goal — detecting early leg muscle loss — it would give you false reassurance.

My Recommendation

Invest in the Withings for long-term leg muscle tracking. Use it under the same conditions every time (morning, fasted, same hydration routine), and track 7-day rolling averages rather than individual readings to further smooth the 0.3 lb noise. Cross-reference with DEXA every 6 months at BodySpec to recalibrate and confirm the bias hasn’t shifted.

The one caveat: all consumer BIA scales are rough tools compared to DEXA. The value isn’t in the absolute numbers — it’s in catching a trend break. If Withings shows your leg muscle rolling average dropping by 1+ lb over 2–3 months, that’s your signal to escalate training intensity or investigate before the next DEXA confirms it. Think of it as an early warning system, not a measurement device.

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