Scientists discover how muscle stem cells “flip a switch” to rebuild damaged muscle
Scientists discover how muscle stem cells “flip a switch” to rebuild damaged muscle Scientists discover how muscle stem cells "flip a switch" to rebuild damaged muscle
When PFKM returns, muscle building begins.
Getting a better handle on muscle loss and rebuilding.
Jagdish carries it now, btw. $128 for 150mg 60 tablets.
Does Maraviroc mechanism of action effect PFKM or anything else for that matter?
Not sure… hope someone on here with more biological expertise can explain.
Looks good….maybe Glycine 3 grams before bed(stacks nicely w/NAC)
Hey Jim,
I take 75 mg… 1/2 of a 150 mg tablet every other day.
That is take one half in the morning (tends to keep me awake if taken at night)… skip dose next day… then take again. Since I take my Maraviroc regularly…I don’t coordinate my Maraviroc with my rapamycin dose.
However, I do take my TRT 200 mg …1 ml weekly injection. … 4 days post rapamycin. Keeping those opposite each other.
Thank you! Good to know.
In prepping for my Maraviroc trial (it arrives Monday!), my PT had me do the hang test for the first time in perhaps a year. (I rarely do it because I loathe it with a passion because it hurts my delicate little hands 
I am significantly stronger than I was a year ago, by a million miles. He expected my hang time to have increased too, but alas, it was even worse… I let go because it just hurts too much and I want it to stop, and not because my hands ‘can’t’ hold on any longer. The distinction of this is blurry because I feel I can’t.
Because grip strength is such an important longevity indicator, how do I look at the fact that I have almost zilch. If it’s pain vs strength related, does that make a difference, or it’s all the same and I just need to try harder and harder?
And while I’m at it, how do you look at muscle vs strength for long term aging? I realize there is some overlap of course.
I will get my annual dexa next week and will have more data, but even though I’m significantly stronger and constantly make new gains, I don’t know that I have bigger muscles.
Because I continue to make new gains, I’m not sure how I’ll be able to tease out what is normal or maraviroc, fyi.
Maybe I am not understanding you correctly, but the hang test would actually be a good measure of strength meaning it tells you how long your muscles (in your hands/arms) will be able to support your weight. The stronger you are the more time you’ll be hanging on. So, not exactly sure where the confusion is. I usually measure it on machines. For example, if I do a daily exercise on a certain machine and normal daily weight on that machine is 50lbs for the three sets I do daily then if I start Maraviroc and couple weeks later I can easily add 20lbs to the 50lbs i usually do that means Maraviroc is making me stronger.
The weird or maybe funny part is I can definitely attest to Maraviroc making me stronger but Only on the days I take it. I take it every other day, and, on the day I take it, I can definitely do about 20% heavier weights but if I don’t take Mara for couple days, I’m back at baseline weights. So not 100% sure what to think of it. Obviously, it does seem to positively affect muscles and strength but not exactly easy to measure the effects on consistent basis. What I can easily notice is the fact that I have more endurance (way past the placebo effect) on the days I take it. I hate exercising naturally (and this was exacerbated even further by doing GLP1’s for past year) and on days I take Maraviroc I have no problem exercising and tend to get less tired. So, it seems like an interesting drug/substance, and I intend to keep taking (perhaps one month on, one off after a year or so of continues use) unless it messes up any of my biomarkers which I have not checked yet but intend to do so in a month or two. My positive results may be somewhat distorted by the fact that I was really beaten down by Tirze/Reta which made me very weak and tired, so Maraviroc has helped me tremendously. I’m not so certain someone that is already at their best or close to it will feel any stronger, especially as fast as I did. In my case within three days of using it (initially daily, and now every other day) I could see myself getting stronger. But definitely a very interesting find as there aren’t many substances out there that I know of that would have such a fast and profound effect on strength (recovering strength in my case) except the steroids which I would not want to try.
Great feedback! I’ll make sure to take it the morning before resistance training to see what happens.
I meant to say…
I am getting stronger all the time… I have not plateaued yet. I have had 2 new PRs in my bench press in just one month… so if I get a new one, will that be from Maraviroc or was it going to happen anyway.
But, now that you’ve shared this, it seems it might be obvious… that I’ll hit a PR, but then the next time I might not be able to move the same weight.
On the hang time for my grip strength….
while I am a ton stronger, my hands hurt when I hang, so I let go… so technically my hang time and grip strength have not improved…in fact, my time was worse… It is what it is, but it’s confusing because I expected to see stronger hands, so it was a little deflating.
Got it. Clear now. Great to hear you’re making progress.
Just to update everyone the Tinnitus has returned as usual, and it appears it had nothing to do with Maraviroc (been on it for two months now). It must have been something else/unknown. It does at times subside a bit (on its own) or perhaps a result of some unknown event but wanted to let everyone know that maraviroc does not seem to effect tinnitus either way (good or bad).
As an FYI I’m still using maraviroc and do like the effect of it.
I have mild to moderate tinnitus. There is nothing that I have ever tried that has had any effect.
But what you describe is common and puzzling to me. If there is no cure, why does my tinnitus vary so wildly. It often almost completely disappears only to return at full force.
From my own research I find it obvious that very little is known about it as to cause, effect, or cures.
Buy a dynamometer for $25 on Amazon. You will only have to tolerate 2 seconds of pain to test your grip strength.
Yes we all have the same experience. On full force, then goes away mostly for no reason. But there is one drug, Colchicine cuts it about in half. I wasn’t sure at first, but I’ve been off and on a few times now and the difference is very noticeable. I’m still not sure about this one. That’s why I take it off and on.
@Bicep Can you clarify the part you are not sure of. Is it in general you are not sure about Colchicine, or you are not sure if Colchicine is helping with tinnitus or not? And @desertshores have you ever tried colchicine yourself?
I’m sure it helps tinnitis, but is not a cure since it comes back when you quit taking it.
I’m not sure I want to poison my microtubules. They’re kind of a magic thing and seem like they could be important. I don’t notice anything different from taking the drug besides the tinnitis. It greatly reduces the chance of stroke and I don’t want a stroke. So I take it off and on and when it’s gone I probably won’t get more.
No, because it has too many possible side effects.
And, " * Narrow Therapeutic Index: The difference between a safe dose and a toxic one is small. Overdose can be fatal and requires immediate medical attention.
There is currently no quality clinical evidence to suggest that colchicine can cure or reduce tinnitus.
So, I’ll pass on this intervention.
I think grip strength is mostly about the strength of the forearm muscles, not how much pressure you can tolerate on your palms or finger pads. Some, like Peter Attia, speculate that grip strength is a proxy for overall body strength because it develops when you lift weights or have a lifestyle that engages with heavy stuff. All the research I’ve read on the topic has been correlational, so I tend to agree with Attia. You might want to consider padded gym gloves to make things more comfortable. I find those help. Some of us lose fat pads in the hands and feet as we age, so that could be a factor in comfort.
That makes a lot of sense! Yeah, even when doing a bench press, while I can press a lot of weight relative to my size, the weight of the bar on my bony little fingers is deathly! I’ll look for a pair of gloves. It takes a village!