Neither Jagdish or Maulik seem to stock this. Thank you @Kelman for sharing another source.
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These sound like important tests. Has anyone else on this drug taken ALT/AST tests and noticed big changes yet?
My bodyweight strength metrics are solid (can deadlift 2x my weight and easily dead-hang for 2+ minutes) but I don’t have a lot of muscle mass and would like to add more.
Do we have a loose consensus on an ideal age to start taking this drug? Currently I am extremely lean despite lifting 3x a week (long distance runner physique with a BMI of 20). Hoping to add some more muscle mass in 2026. Taking in 1.6g of protein per kg of bodyweight and eating a a surplus of about 200kcal to my TDEE currently.
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You able to record any videos of your lifts and upload to YouTube?
It would be great to see videos of your lifts.
Even if it’s just the best set of each exercise, that would be fine.
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Heading to Japan this week for 10 days… for university work. But, sure once back. I can show stuff on here… @RapAdmin has let me load vids in the past.
Pretty typical machines at any decent gym would have… pec deck, lat pull-down, etc. TBH feel great… but a bit oblivious to where I stack up physique-wise. Told I look like a gym bro… 
. Gunny considering how much I really hate working:muscle:out … but do it anyway.
Feeling too good to go back to the old un-toned me.
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I got it easily and right away from Laxminarayan, but $140/bottle. I’m a terrible shopper and never argue with anybody. If I’m happy with the product I’ll work it a little better next time.
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Yes - https://www.laxminarayanint.com is about 300% to 400% more expensive on the quotes I’ve seen from them (vs. the normal resellers)… just way, way out of line with the rest of the market. See this example: Buy Rapamycin Online - List of Reliable Pharmacies - #903 by desertshores
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I think you mean 30-40%, 140vs cheapest I got 110-115. Even at $140 doesn’t seem too bad. Most quotes I got were in 150-180 range, except a couple.
I was referring to where Desert shores says, for Dasatinib: "NIBA Healthcare India· Price : 30 USD per Pack of 60 Tab · Shipment Charges.
Vs. $135 from Laxmarayant for same quantity.
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Got it. thought you were talking about Maraviroc.
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Okie dokie,
I think I’m finally caving on this one. I see it’s $224 at good rx for 30 pills 150mg each. I’ll see if my doc will give me an rx.
According to AI, I’d be taking 1/4 of a pill EOD, but the discussion here makes it seem it should only be twice per week?
I take it the potential liver effects are the main thing to watch out for. Does anyone have a recommendation on how often we should check labs? I typically test every 3-4 months. Maybe after 30 days of trying it?
Also, because my PT tracks exactly how much I can do, perhaps I might be able to be of use and do some good measuring to report back. If so, what would you like to see, before and afterwards? How much I can bench? Or? I hate the hang test, so don’t ask me to do that! (It hurts my fingers! 
My hope is extra strength translates to extra stress on my bones.
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Grip strength and machines are good - things that don’t depend so much on technique.
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Yes… it takes a second to figure out the form… and gripping method… I suggest practicing a bit… to get the feel. Measure each arm.
Average grip strength for women aged 40–50 is approximately 48–63 lbs, decreasing slightly to 43–61 lbs for ages 50–59.
My male grip was 95 and 110. Considered Good.
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Do we have consensus for prophylactic dosing for the elderly.?
Based on my own measurements from the past, I don’t think I would be taking it if I was under 60 years of age.
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Actually, I do have one of those little grip strength gadgets that I forgot about! Good idea to whip that out.
Machines make sense, but there aren’t any where I workout. I could go to a different gym I have access to and do a before and after. Would you suggest just picking a weight that seems hard and counting my reps to failure… then doing that same thing a month later?
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This is a really good question. Since what this drug does is purge senescent cells, the key thing to understand is when do senescent cells start to ramp up, and by how much. So I tried to get an idea from Gemini on this issue. It seems it’s cell-type specific, and probably quite specific to the individual and their history (do you have a history of obesity, etc. - which ramps up senescent cell load much faster than otherwise), etc.
Bottom Line Up Front: The accumulation of senescent cells in human skeletal muscle is compartmentalized and nonlinear. Unlike adipose tissue, which shows robust, generalized senescence accumulation with age, skeletal muscle senescence is primarily restricted to the stem cell niche (Satellite Cells) and Fibro-Adipogenic Progenitors (FAPs).
Quantitative Reality:
- Myofibers (90% of tissue volume): Do not undergo replicative senescence. They exhibit “post-mitotic dysfunction” (DNA damage accumulation), but rarely express classic p16INK4a or SA-beta-gal markers unless the subject is obese or physically inactive.
- Progenitors (Satellite Cells/FAPs): Exhibit a “hockey stick” trajectory. Accumulation is negligible (<1%) until approximately age 65-70, followed by an exponential rise that drives regenerative failure (sarcopenia) and fibrosis.
Critical Confounder: Recent data explicitly decouples chronological age from senescence in muscle. High BMI and metabolic dysfunction are stronger drivers of p16INK4a expression than age alone.
Here is the full response:
Muscle Senescence_ A Systematic Review.pdf (121.1 KB)
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It’s probably better to do something that you already do regularly so you know what your usual progression looks like. What about push-ups or body weight squats?
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Yes, push ups… pull ups… a lat machine or chest machine (pec deck)…
Maximum weight for 10 repetition.
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@Agetron @AgentSmith I’m on it, thanks!
I am still continuing to get stronger all the time (YAY ME), so I won’t know exactly how to tease it all out, but my PT is hyper-aware of everything I can do, even when my form improves he makes comments (I’m oblivious), so I’ll be sure to include him on this
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Yes Jay, I have osteoporosis so anything I can do for bone density to protect me long term is a big goal. It’s holding steady and not getting worse, whew.
I have a very tiny frame so my bones are naturally very small. Wrists of a toddler
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