What supplements do you take to enhance the effects of Rapamycin?
My layman’s understanding of how Rap works:
Rapamycin > mTOR inhibition > autophagy engagement > lysosome activity
It’s this lysosome activity that generates all the benefits at the cellular level. I found this interesting:
“During stress conditions, autophagy can lead to cell survival through lysosomes activity. Autophagy relies on lysosomes to degrade harmful, dysfunctional cell components and misfolded proteins. It then converts these parts to amino acids and sugar to reuse. TRPML1, the main calcium channel, is critical in regulating lysosomal function. Without this, cells become cluttered as we age. Rapamycin activates this channel, regardless of mTOR activity, and enhances autophagy dependent on TMRPL1. It may contribute notably to the anti-aging effect of rapamycin.”
For myself, I get a surge of sustained energy after the first 3 days when I take my weekly Rap, that gradually tapers off over the 7 days. I enjoy this so much that I take my Rap on Friday morning so I can have optimal energy to enjoy weekend activities Lol
So, are there any supplements that can be taken along with Rap to enhance autophagy and lysosome activity?
There seem to be a few supplements / compounds that help with autophagy (not sure if they are synergistic)… Trehalose and Spermidine come to mind. Also, Fasting is a good way to boost autophagy. But its still early days… we don’t have a way to measure autophagy in the clinic yet, so lots of guessing going on.
If you take grapefruit juice 1-4 hours before Rapamycin, you effectively triple the amount your body absorbs. But that’s similar to taking 3X as much Rapamycin. However it may do the same to other medications you are taking, so you really need to check first.
Taking Rapamycin with a fat source increases absorption by 30%.
No TRT but it’s something I have considered… there is a longevity theory that makes some sense to me, in that you can’t stimulate growth and longevity at the same time, one is at the sacrifice of the other… but perhaps the way you are approaching it might strike an effective balance.
How do you acquire your cypionate?
btw, Rufus Dawes is just my profile name LOL, he is a famous Civil War hero and have always thought it was a cool name
To rephrase my question: Are there any studies showing the benefits of very high doses?
I now take 20 to 60 mg nightly and really don’t feel any subjective experience over 1 to 10mg nightly. Can I expect to see any changes in any of my blood markers from taking these higher doses?
AFAIK there are atudies on the anti cancer effects of high doses. My view is that there are no studies implyjng any harm although there is a study about small hamster testes. I have no tested the effects on fertility, but i have 5 children and am not concerned if in improving my health i have lower fertility.
It would be good to have more detailed study of dosing at my level. However, I am happy with my own outcomes. I do weekly bloodwork.
There are more than one areas where i think i am an outlier and i tend to try a lot.
I had not read the 10 mi half life. I would quite like to know the precise details of how melatonin is processed. I think the curve for high doses is different. I have searched this, but not found anything.
No - GFJ interactions with other medicines: The key issue is you have to be very careful if you take other medications in addition to grapefruit juice (or ketocanazole, etc.). Common medications like statins, blood pressure medications and others can have bad effects when taken with grapefruit juice - so talk with your doctor and do research before considering this.