Air pollution and the effects on health

Just here to say that you and @Steve_Combi convinced me to use them all the time and not just when there is wildfire smoke in the area. I bought that same Coway on Prime Day a few of you recommended.

I thought I would have zero tolerance for the noise (and seeing it), but nope, on low, I barely notice it, and that good ol’ Coway is so compact it is hidden by my end table and I rarely even see it. So, I’m really only chiming in to gives a huge thumbs up to that Coway for cost/looks… highly recommend.

I have a huge Levoit hidden behind something in the bedroom. I’d swap their locations if we had some smoke in the area.

We have particularly good air quality in my town, so all this is probably for nothing, but I do feel better for having it. The only time it has kicked on higher is when I’m using a little diatomaceous earth (for non toxic bug control).

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After Parkinson’s disease dementia now we have AD… Ambient Air Pollution and the Severity of Alzheimer Disease Neuropathology 2025

Higher PM2.5 exposure may exacerbate Alzheimer disease neuropathologic change and cognitive dysfunction in the setting of dementia; population-based autopsy studies are further needed to generalize these findings.

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OK, I have no doubt that that there are all these effects of air pollution (and water etc.) on health on a population level. But this can easily be misunderstood. Air pollution is not a new phenomenon. There have been extremely polluted environments since before the industrial revolution but especially so after. We have extreme examples with mine workers, black lung disease and so forth. But car exhaust pollution (including leaded gasoline) has been around for decades in major cities around the world, London, Tokyo, NY, LA etc. Has there really been an epidemic of AD, PD and all these effects from 50’s onward? We’ve had the famous smog deaths in London, but what about long term effects? It’s only been relatively recently that we’ve removed lead from gasoline.

Meanwhile, epic levels of air pollution in places like China, India, Indonesia and parts of Europe back in the day - some persist to this day, New Delhi, Kolkata, Mumbai and cities in China still suffer from quite a bit of air pollution. So my question is: WHERE ARE THE BODIES?

Where are there legions of PD, AD and so on? If I look at the map of the “PD belt” (you can google for it), it doesn’t map to the obvious air pollution cities. Are there epic levels of AD per 1000 population in places where air pollution has been bad for decades, like Los Angeles CA? I don’t think so.

Again, I’m not doubting the data, or the impact of air pollution. Just that it’s only one factor of many (in rates of PD, AD, cancer, CVD, and so on), and - dare I say it - not an especially important one (compared to others), if one goes by the numbers. YMMV.

The same is true for many other things, like plastic pollution. I have zero doubt that microplastic particles get into the human body and are a definite negative. The problem is we don’t know the relative size of the problem compared to other pollutants and impact on health.

It’s good to be aware of the dangers of air pollution and the like, but ultimately we should not lose sight of relative importance. Effort and attention should be apportioned according to the importance of any given factor.

In this context one can ask - we know air pollution is bad for health in the respect of X, Y, Z, but how bad for each and how bad the pollution to get a given outcome. How exercised and paranoid should we get about air pollution (while perhaps neglecting more important factors). One crude way of asking for that is: where are the bodies? YMMV.

There are so many issues and health hazards in these areas that I have to believe it would be very hard to parse out the different cause/effect relationships with a given person’s mortality. Poverty, noise, toxins, stress, extreme heat, getting hit by an auto-rickshaw at high speeds… the list goes on.

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OK, but China has statistics. Are the rates of PD and AD higher in Beijing than some smaller cities with better AQI? Or for that matter Los Angeles, CA famous for terrible air quality for literally decades.

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Of all places and times in history, Parkinson’s disease was first described and discovered in 1817 in London when the fog started with industrialization.

Air pollution improved in the West over the past decades and AD age-adjusted prevalence is decreasing as well.

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The Lancet commission on dementia prevention considers that 1% of cases are due to air pollution.

We have longitudinal studies (above + https://www.thelancet.com/journals/lanplh/article/PIIS2542-5196(25)00118-4/fulltext ) , mechanistic studies and animal models ( Air pollution and the effects on health - #42 by adssx ) and Mendelian randomization (although I find an MR for that very very weird but ChatGPT tells me it makes sense :man_shrugging: https://www.sciencedirect.com/science/article/pii/S1309104225002004 ). What else would you like to see?

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Again, I don’t doubt that air pollution increases the rates of PD, AD and cancer. But it’s a minor contributing factor. What I would like, is an explanation, of why for example the “PD belt” does not coincide with the most air polluted areas. The point is that the likely reason is that the polluted air is minor compared to some other factors which occur in the “PD belt”. Air pollution is a factor, but a minor factor compared to other pollutants (for example in rural areas).

The answer to your question is in this sentence.

Oops it’s 3%:

17573953769406139146748822777350

Source: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01296-0/abstract

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And sorry for the triple post but you’re asking about PD even though the above articles are about AD and LBD/PDD. I don’t know if we have that strong evidence for PD itself. For PD we have more evidence for chemicals, heavy metals and pesticides, which might explain the PD belt: Mystery of America’s ‘Parkinson’s Belt’ Where Chemicals ‘Are · Parkinson's Resource Organization

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