It would take an absolute miracle drug to get any meaningful life extension in renal transplant patients. They have multiple co- morbidities , but perhaps those on rapamycin live longer than the groups on cyclosporine. I have no idea.
Is there good human data on metformin and life extension ? I’m referring to non diabetics.
Unfortunately no studies with healthy study subjects. When Metformin received so much attention for its anti-cancer effects, this was seen in patients suffering from T2D with low HDL-cholesterol. Difficult to draw any solid conclusions from studies that show results in such a specific group of patients. Wish the TAME trial would start already.
I believe the link to the paper is at the beginning of the video. It seems the numbers aren’t as impressive when the short lived controls at the University of Texas are removed.
Acarbose was only effective for male mice. I tried to find an information of the effect on females/males people and only found one study : Li J, Li J, Shan Z, Yang W, Liu J, Tian H, Zhou Z, Ji Q, Weng J, Jia W, Lu J, Liu J, Xu Y, Yang Z. Gender-differential effects on blood glucose levels between acarbose and metformin in Chinese patients with newly diagnosed type 2 diabetes: a sub-analysis of the MARCH trial. Endocr J. 2021 Jan 28;68(1):69-79. doi: 10.1507/endocrj.EJ20-0006. Epub 2020 Sep 10. PMID: 32908086.
Are you aware of any other studies on the effect of Acarbose for female patients compare to males?
Does it even make sense for females to take Acarbose ?
Ah - I spoke too soon. Just found this study out of China on people with diabetes. This is the only study on this that I’ve seen so far. Not sure if it applies to healthy people, but something to be aware of:
I will track my lean muscle mass over time with DEXA scans anyway, so I’d see if this is an issue with me. I’m also (independent of this study, for other reasons) increasing my workout schedule from approx. 4 hours/week towards 6+ hours/week.
Thanks, I guess I´ll try to at least wait for a few hours after my workout to take acarbose. On non exercising days I´ll combine acarbose with metformin
The negative study also indicated that Metformin reduced muscle mass but not muscle function. I will settle for a smaller muscle that functions as well as the larger one.
I take 50mg or 100mg, taken with the first bite of a higher carb meal. Acarbose has a short half-life, so is effective only for about two hours after taking it.