Acarbose - Details On Another Top Anti-Aging Drug

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#69

Here is the paper New Paper: Lifespan Benefits for the Combination of Rapamycin plus Acarbose in mice

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#70

Acarbose was only effective for male mice. I tried to find an information of the effect on females/males people and only found one study : Li J, Li J, Shan Z, Yang W, Liu J, Tian H, Zhou Z, Ji Q, Weng J, Jia W, Lu J, Liu J, Xu Y, Yang Z. Gender-differential effects on blood glucose levels between acarbose and metformin in Chinese patients with newly diagnosed type 2 diabetes: a sub-analysis of the MARCH trial. Endocr J. 2021 Jan 28;68(1):69-79. doi: 10.1507/endocrj.EJ20-0006. Epub 2020 Sep 10. PMID: 32908086.
Are you aware of any other studies on the effect of Acarbose for female patients compare to males?
Does it even make sense for females to take Acarbose ?

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#71

Does Acarbose interfere with the benefits of exercise like metformin ?

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#72

No - there is no evidence of that.

#73

Thanks so much as I want to add Acarbose to my after workout whey drink

#74

Ah - I spoke too soon. Just found this study out of China on people with diabetes. This is the only study on this that I’ve seen so far. Not sure if it applies to healthy people, but something to be aware of:

I will track my lean muscle mass over time with DEXA scans anyway, so I’d see if this is an issue with me. I’m also (independent of this study, for other reasons) increasing my workout schedule from approx. 4 hours/week towards 6+ hours/week.

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#75

Thanks, I guess I´ll try to at least wait for a few hours after my workout to take acarbose. On non exercising days I´ll combine acarbose with metformin

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#76

I think as a 81 yr old taking metformin for decades that its effect on exercise is highly overblown.

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#77

The negative study also indicated that Metformin reduced muscle mass but not muscle function. I will settle for a smaller muscle that functions as well as the larger one.

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#78

For those using acarbose, what is your dose and schedule?

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#79

50 mg with any medium to high carb meal, usually only dinner.

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#80

I take 50mg or 100mg, taken with the first bite of a higher carb meal. Acarbose has a short half-life, so is effective only for about two hours after taking it.

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#81

I take metformin like a champion. I am still looking for the opportune moment to utilize my stash of Acarbose.

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#82

Very interesting, thank you

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#83
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#84

Acarbose longevity benefits are believed to arise from it’s ability regulate microbiome, and also to prevent blood sugar from rising quickly after eating, however based on the quote above, it doesn’t necessarily result in an overall change in amount of glucose entering blood stream. Is that accurate in humans or just mice?

For healthy people concerned with athletic performance, consuming carbs and glucose provides a critical source of energy for optimal workout performance and strength. Keto diet is known for having a detrimental effect on muscle building and athletic performance under certain conditions. For example, The higher the total volume of work performed in training, the more reliance on glycogen and carbohydrate to potentiate that performance.

When exercising at a high intensity between one and three minutes, the body primarily uses the glycolytic energy system, which — as the name suggests — runs off of glucose, which comes from carbs. If you’re in ketosis, your glycolytic system isn’t running properly, and your performance suffers.

With respect to Acarbose:

  • Are there athletic performance related side effects caused by blunting postprandial glucose levels as a consequence of taking Acarbose before carb heavy meals?

  • Would this postprandial glucose response from Acarbose cause a similar dip in certain parameters of athletic performance as those caused by athletes on a keto diet?

  • Are there any specific side effects related to combining Rapamycin and Acarbose?

  • Is the general consensus that the mice studies showing combination of Rapamycin and Acarbose results in greater percent lifespan increase would carry over to humans in the same way that Rapamycin alone does?

  • It’s recommended to take Acarbose before a meal with med/large quantity of carbs. Is there a specific number of grams of carbs that constitutes med/large carb meal?

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#85

I have taken my shiny new Acarbose drug twice now and so far no side effects whatsoever. 50 mg.

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#86

Did did you take it with complex carbs such as bread, rice, potatoes, etc? If not, there’s no side effects because the acarbose didn’t really do anything (no starches were passed to the colon for fermentation).

I tried my newly acquired acarbose yesterday with starchy meals and WOW – most prolific and smelliest gas I’ve ever had! Good thing my wife is out of town or she would have murdered me by now!:laughing:

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#87

I just recently started taking Acarbose. My own experience so far:
Little or no gas when taken with a low-carb meal.
Most salads using Italian or vinegar and oil produce very little gas.
I was surprised that moderate pasta intake didn’t produce much gas.
What does produce a lot of gas for me is anything with a high sugar content such as cake, ice cream, starchy vegetables, etc.

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#88

Yes - it can be really bad. What type of starchy foods did you eat? I think wheat-based products make it much worse.

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