Hahaha, okay… your Zydus shows the molecule rapamycin is in your blood. Congrats.
Unclear how you are getting your numbers.
Typically a person goes for a full week after last dose. Your trough… typically a week later you would be under 1ng/mL. You say you are at 10.6ng/ml at trough?
Did you mean you had 10.6ng/ml 3 hours after your dose? That would make more sense.
Take your Zydus pills (4mg or 6mg)… then get blood tested no earlier than 2 hours or later than 3 hours is good.
You should be getting about 3 ng/mL for every 1 mg of Zydus 2-3 hours after your dose. So at 5mg you should be at 15 ng/mL.
As to SiroBoon… sounds lke it is crap… everyone on here tests and no rapamycin in it.
Your earlier post:
“As of now having been taking rapa for many months only to discover bogus meds. Biodin and Zydus.”
Rapid Absorption: Under fasting conditions, sirolimus is absorbed quickly, reaching peak blood levels (Tmax) within approximately 1 hour.
Dose Proportionality: In the therapeutic range, Cmax increases roughly linearly with the dose. A 5 mg dose typically results in a peak concentration about 2.5 times higher than a 2 mg dose.
Food Effect: Consuming a high-fat meal significantly alters these parameters. It can delay Tmax (up to 2.5–3.0 hours), decrease Cmax by ~34%, and increase total exposure (AUC) by ~35%. The graph above models the fasting state.
Elimination: After the peak, levels drop relatively slowly due to the long half-life (~62 hours in healthy males), meaning a single dose remains detectable in the blood for several days.
Scholarly Note on Variability: While these curves represent the “typical” male, actual blood levels are heavily influenced by the activity of the CYP3A4 and CYP3A5 enzymes and the P-glycoprotein transporter. Individuals with high metabolic activity (“rapid metabolizers”) may see lower Cmax values, while those with inhibited pathways (or taking CYP3A inhibitors like grapefruit juice/ketoconazole) may experience significantly higher spikes.
Do you a gree that weekly dose that leave near 0ng/ml at trough is better than twice weekly 1/2 per dose? At this point I will be taking 6mg once a week.