I’ll add my endorsement. Back in 2021 and 2022, I was taking 12 mg of Zydus with grapefruit or grapefruit juice every 2 or 3 weeks, not worrying about precision in the dosing intervals, and posted my April, 2022 lab result. Blood was drawn 2 hours after dosing. It was 68.3 ng/ml - the multiplier in close agreement with both of yours.
For no real reason other than it seemed I was pretty far out of line with what everyone else was doing, I took a few months vacation from rapamycin and am now doing 2 mg with grapefruit juice, once a week. Everything’s about like it was then, I guess - no side effects or benefits that I’ve noticed.
Personally I prefer the taste and positive results from one Red Grapefruit I buy for approx $1.18 at Wal-Mart produce. I quarter and squeeze the slices through a strainer and get about 5 fluid ounces. Which I take with my 2 mg pill - together one big gulp. It is plenty for the 6 times multiplication increase of my rapamycin/siriolimus/rapamune/zydus dose.
I have also in the past used the Simply Brand GFJ (although pasteurized - it is not an issue) and gotten the same 6 times increase results.
I know others on this site eat a grapefruit hours or a day before and then another an hour before and another with the dose and then one more an hour after ther dose.
OMG… too much GFJ and too complicated for me. So I don’t think quantity of GFJ matters (5 oz. or 20 oz.) in increasing the dose potential… based on my one little 5 oz. juice glass full - it does the trick. One and done. The Labcorp test shows for me - one time, 5 oz of GFJ with the pill is enough.
I take 12mg of Rapa with the juice of two grapefruit. Watch out for LabCorp results. There are articles about LabCorp employees sabotaging results because of dissatisfaction with management. My $600 Men’s Elite Panel through Life Extension (done every year) came back with my T at 1500. No way accurate. On Reddit.
FWIW, I did a comparison between Zydus and Eris/Biocon earlier this year. Same dose (6mg once a week), taken the same way (empty stomach after overnight fast) sirolimus test after 50 hours in both cases, both tested by the same lab (LabCorp) at the same location (Beverly Hills). April: Eris/Biocon - 5.6 ng/mL, June: Zydus - 4.4 ng/mL.
So from my n=1 experiment, one test of each brand, Biocon was substantially more present in blood than Zydus. Make of that what you will. I still have some 200 1mg Zydus pills, but for now I’m sticking with Biocon. YMMV.
I always gauged whether my Rapamycin was legit or not by measuring the side effects. If I got mouth ulcers or rashes, I would know it’s the real deal. (I can’t get a Rapamycin test here in HK).
Yes, I think you should wait a couple of hours before testing. You should not get a 0 value. It is possible that the testing lab made a mistake, but that is a very rare occurence, IMHO.
@Agetron If you tested it with 4 mg, you should see a result. It should work. Maybe he should send you some to determine if it is a fake? @CoachHarvey
Kimalya Pharmacy. Why wouuld your pills from Zydus be yellow and b marked 21. Mine from Zydus white and no number on them? I wonder how yours come? Ours are in 6 tab strips. I see some Zydus comes in 10tab strips. Why. Is it possible to forge a mfc? Anything is possible.
@Agetron Thanks for the info. Have a question dosing and blood level, which I know is far from settled, but I’ll ask your best opinion anyway: What is the optimal sirolimus level one should vouch for, or is it a case of the higher the better?
Its actually a good thing you didn’t now the sample size is N+2.
