Here it is:
More Rapamycin Might Not Be Better
1 mg rapamycin = 3 ng/mL in the blood.
At 38 ng/mL I was at a 12 mg + dose weekly.
Enjoy!
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The tablets come in what certainly looks like the manufacture’s strips. I had a blood test for Biocon, which was the lowest price and just had a blood test the Zydus both show next to ZERO in my blood. Is it possible that my metablism is such that there is not half life
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How significant is the grapefruit for the Zydus tabs to be effective. I’ve not taken the meds with gf. and my tests both times have come in at ZERO ng/ml
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As of now having been taking rapa for many months only to discover bogus meds. Biodin and Zydus.
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How long after dosing did you do the blood test. The blood test is for sirolimus (it is all the same molecule).
Typically you do a test 2 full hours after dosing … not later than 3 hours. Some people have a fast metabolism of it - like Matt Kaeberline.
My first test was a few hours after dosing results zero. The next was at trough results zero.
Sorry, but your description of two meds being tested is confusing. Getting a trough when you already had zero at dose makes no sense to test for a trough.
To keep this less confusing… I am only curious about your Zydus sirolimus testing. You took the dose of 4 mg… 6 mg zydus sirolimus… and had blood drawn for testing in a lavender topped tube 2 hours later. Results showed no medication in your system.
Again, if you want to shoot me a few pills (in blister pack), I can take and test with LABCORP end of January when I do my full blood panel. Will use your meds a few hours early for my trough. Test my meds 2 hours later. Always good to double check. I have never had any testing issues in 4 plus years of testing every 3-4 months.
Up to you.
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What was your testing protocol? How many hours after dosing? Did you take any supplements in the hours prior to dosing? Which ones? Lots of things can influence the blood levels.
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Highly doubtful you’re getting bogus meds, let alone from two different brands. Though perhaps it’s possible that these drugs were stored at high heat in India prior to shipment and that might affect your blood results. One of the downsides of ordering medications from India is you don’t know the supply chain, and India (with its extreme heat during parts of the year) storage could be a significant issue I suspect.
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Since he said that the blood levels showed ZERO then there’s got a be either fake meds (which I doubt) or maybe botched lab work (some kind of mix up). Had it been other factors (as you mention) he should at least have shown some level, not just zero. Plus, his pills (pic he posted earlier) I think showed different color and shape than regular Zydus rapa. His case seems very unusual given its first time I hear such claim in these forums. Would be interesting to know who sold him the meds (if there was one of the usual guys we order from, or it was someone new/random)
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I’m taking the same Zydus. I bought from India with the same package. I’d like to send some to you. I come from China. Plz send your address in private. Thx.
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There’s no such blood test in China. Sad.
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Oh you are in China?
I get my HGH human growth hormone from there.
Very good product. Yes I can test your sample.
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Thanks. I bought my Zydus rapamycin from India. haha. 
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Are you sure you’re ordering the right blood test?
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I just tested Zydus 5mg 3hrs before Blood draw for peak got 10.6ng/ml by QuestDiagnostics. Got the results next day. After getting a years supply of SiroBoon2 by Kachhela I tested 6mg for peak 3hr Blood draw results <0.1 bt Labcorp. They were the lowest price and worthless. My grandmother use to say, “vats cheap is expensive”.
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Hahaha, okay… your Zydus shows the molecule rapamycin is in your blood. Congrats.
Unclear how you are getting your numbers.
Typically a person goes for a full week after last dose. Your trough… typically a week later you would be under 1ng/mL. You say you are at 10.6ng/ml at trough?
Did you mean you had 10.6ng/ml 3 hours after your dose? That would make more sense.
Take your Zydus pills (4mg or 6mg)… then get blood tested no earlier than 2 hours or later than 3 hours is good.
You should be getting about 3 ng/mL for every 1 mg of Zydus 2-3 hours after your dose. So at 5mg you should be at 15 ng/mL.
As to SiroBoon… sounds lke it is crap… everyone on here tests and no rapamycin in it.
Your earlier post:
“As of now having been taking rapa for many months only to discover bogus meds. Biodin and Zydus.”
So… now you believe your Zydus is good.
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There is lots of individual variation in this… and we have no idea what @CoachHarvey takes in the way of drugs, supplements or foods in the hours prior to dosing with sirolimus… Rapamycin Interactions with Other Food, Drinks, Supplements and Drugs
Key Pharmacokinetic Insights
- Rapid Absorption: Under fasting conditions, sirolimus is absorbed quickly, reaching peak blood levels (Tmax) within approximately 1 hour.
- Dose Proportionality: In the therapeutic range, Cmax increases roughly linearly with the dose. A 5 mg dose typically results in a peak concentration about 2.5 times higher than a 2 mg dose.
- Food Effect: Consuming a high-fat meal significantly alters these parameters. It can delay Tmax (up to 2.5–3.0 hours), decrease Cmax by ~34%, and increase total exposure (AUC) by ~35%. The graph above models the fasting state.
- Elimination: After the peak, levels drop relatively slowly due to the long half-life (~62 hours in healthy males), meaning a single dose remains detectable in the blood for several days.
Scholarly Note on Variability: While these curves represent the “typical” male, actual blood levels are heavily influenced by the activity of the CYP3A4 and CYP3A5 enzymes and the P-glycoprotein transporter. Individuals with high metabolic activity (“rapid metabolizers”) may see lower Cmax values, while those with inhibited pathways (or taking CYP3A inhibitors like grapefruit juice/ketoconazole) may experience significantly higher spikes.
Sources: Clinical Pharmacology Biopharmaceutics Review (Rapamune), PubMed (PMID: 11034258, 16418694).
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Do you a gree that weekly dose that leave near 0ng/ml at trough is better than twice weekly 1/2 per dose? At this point I will be taking 6mg once a week.
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True… everyone is different in absorption and clearing rapamycin.
I think weekly dosing works for me and most people.
Based on Matt Kaeberlein and others who report on cycles/dose, you want to be as close to a zero trough before dosing again.
You want to tamp down MTOR1 for several days catabolic and then let MTOR2 grow for several days anabolic. You need both clearing and growing.
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