Semaglutide oral - 3mg daily (started 2 weeks back)
Rapamycin ~ 10 to 15 mg every 2-3 weeks (higher the dose, longer the interval)
B-complex daily with additional B12 and B3
Fish oil around 5, 1g capsules spread throughout the day
Vitamin D3 - every other day
Cialis 5mg a couple times a week at lower dose for longevity purposes.
Senolytic course once in 2 weeks or once a month - Dasatinib (12.5 - 25 mg) + Quercetin (1.5g) + Procyanidin (apple flavanols) + Fisetin (1g) +Luteolin (300mg) + cocoa flavanols + blueberry flavanols + black elderberry extract
17alpha estradiol topical on my scalp during the day
17alpha estradiol topical + liquid melatonin + dmso on my scalp in the night
Finasteride - microdosing at 0.25 mg three times every week
Per needed basis for blood glucose control:
SGLT-2 inhibitors – when I am eating sugary, carby, or heavy meals. I avoid this soon after a rapamycin dose because I don’t want to be susceptible to UTI. 20mg empagliflozin or 200mg canagliflozin
Acarbose – before eating starchy food.
Luteolin – before any fructose consumption
Psyllium fiber before carby food to prevent glucose spikes and also to enable feeling of satiety.
Berberine – rarely, usually on a sedentary day, and sometimes after a super heavy meal.
Creatine – a couple times a week
Exogenous ketones / MCT oil with coffee in the morning sometimes
Allulose Almond meal Brownies baked a low temperature with (relatively unprocessed) cocoa powder +raw cocoa nib
I don’t know what Dave Asprey’s regimen is regarding rapamycin - but he takes so many things, from so many people, its hard to follow. Also - since he’s just a business person by training (Wharton MBA) - I don’t follow him so much on the science.
Did you see our page on the current activities of longevity researchers with regard to rapamycin?
I got a test. I seem to have normal hemoglobin count (in around 50th percentile), with ferritin levels of around 40 (5th percentile). I still can’t tell if this is near-optimal, or if I have iron-deficiency without anemia, or if I want to donate blood and further prevent iron-dependent aging. Sigh.
I’m wondering if I should try experimenting with iron supplements and then donate blood after a month or two in any event.
Ferritin levels are a bit of a murky topic. 40 might actually be really good for longevity purposes, since you aren’t at the very bottom of the normal range and you aren’t anemic per your CBC. There may be some studies out there correlating ferritin levels and disease states such as CVD, might be worth a PubMed check
Medications: Sirolimus 4mg weekly, Selegiline 5mg 1/4 tablet 4 days per week, Dapagliflozin 5mg approximately twice a week when eating more carbs, Tadalafil 10mg twice a week, Atorvastatin 20mg every other day to keep LDL under 70
Took 1 dose of Dulaglutide 0.75mg earlier this week. This has definitely decreased my appetite significantly. If I have breakfast in the morning I feel no hunger through into dinner time. I have experienced constipation with Dulaglutide that requires concurrent use with Senna and Docusate. I may extend the dosing frequency to every 10 days depending on how I feel.
Note: If you plan on purchasing life insurance it would be best to pay out of pocket for Sirolimus and any diabetes drug being used off label. I was recently denied supplemental life insurance through my employer citing Milliman Intelliscript.
Supplements: Niacin 500mg every other evening, Essential Amino Acids 10g (Optimal Amino) pre-strength training and daily, PrimaVie Shilajit 250mg daily 4-5 days per week, Theanine 200mg at bedtime, Liquid Vitamin D 5000 units/K2 200 mcg twice a week, Q10 200mg daily