I have not taken any anti-aging drugs yet. I will try 1) capers (substitute for rapamycin - has more affinity to Everolimus), 2) myricetin supplement or cranberries (trametinib substitute), and 3) lithium.
The docking studies support Kaempferol to be a potential ligand with docking score values of 33.4 (3CQU-3D structure of AKT1)] and 27.3 (2FAP-3D structure of FRB domain of mTOR) respectively as compared to that of standard drug Everolimus with 24.4 (3CQU-3D structure of AKT1) and 20.1 (2FAP-3D structure of FRB domain of mTOR) respectively. Docking studies along with ADMET results shows that Kaempferol has favorable drug likeliness properties and bind to the same active site (site1) of the targeted proteins (3CQU-3D structure of AKT1) and (2FAP-3D structure of FRB domain of mTOR) where the standard drug Everolimus is known to bind. Conclusion The study exhibited that Kaempferol was having a better binding affinity towards the receptor FKBP12, a Rapamycin Binding Domain and AKT serine/threonine-protein kinase resulting in its better efficacy in the mTORC1 inhibition as when compared with standard drug Everolimus against HCC.
Capers have the highest level of kaempferol.
It just got dried capers in salt two days ago. Rinsed them several times, to remove the salt, and soaked them overnight for good measure. Dried them in a dehydrator. Waiting for the myricetin to arrive in two days. Lithium? I am poking around to find out a suitable dosage.
I plan to take it three days a week. Most people here take rapamycin once a week. Because of the half-life, the rapa, probably stays in the body about three to four days. Myricetin has a half life of eleven hours. But kaempferol has a half life of only 3-4 hours. I have to plan a more frequent dosing, maybe BID or TID.