After watching the latest Matt Kaberlein video, I realized that many of us are taking a bunch of supplements, which may or may not be suitable for everyone. I wanted to start this topic so that we could shortlist those small molecules that ALMOST EVERYONE should be taking for improved health and why we think so. Then the rest of us can play devil’s advocate until we get a very tight list of universal recommendations for supplementation. I’ll start it off
Rapamycin - Who wouldn’t want an extra 30% lifespan? It extends life in almost all trials for all model organisms (at least 64 studies done!) It’s a senomorphic and prevents senescence. All around best life-extending small molecule that we are aware of now.
1.5 Acarbose - Along with Rapamycin, these two produced the highest increase in longevity in the
ITP mice trials.
Yes, creatine is a must for prevention of sarcorpenia.
I am battling the problem of taking too many supplements. My goal is just to keep the list to 10 or fewer. Right now I still have a cupboard full of supplements. Of course, I don’t take all of them on any given day.
I would add to your list:
Metformin: "metformin may actually slow aging and increase life expectancy by improving the body’s responsiveness to insulin, antioxidant effects, and improving blood vessel health.Sep 29, 2021 (Is metformin a wonder drug? - Harvard Health)
The capsules are definitely not hermetically sealed and neither are the containers especially after opening. I prefer canned cod liver or soused herring (Dutch specialty do hard to get elsewhere) for omega 3
Were those studies that showed benefits using fresh product? I suspect so.
But there also have been advances in stabilizing encapsulated fish oil. I am unable to find out if there is special processing or stabilizers added to the products we buy. If so, I havent seen it mentioned on a label.
Does anyone have a contact with a fish oil processing company that could shed some light on this?
I think I have come to realize that compared to Rapamycin, all the other supplements are just noise in terms of longevity. I have already started to pare back on the ones I am re-ordering. I am really going to scrutinize which ones are really worth it or not.
I dumped all my red yeast rice supplements last night. More to follow. @Maveric78 will be proud.
Omega 3 supplement study results are really a mixed bag of good results and no results and as said even if the supplements are good when you buy them they will go rancid once you open them. Try chewing your capsules and taste them, good omega 3 oil will taste creamy and buttery with no fishy aftertaste taste
Selenium should be considered for your stack. Frankly, if I had to choose between omega3 supplementation and selenium, I would opt for selenium
Over the years of reading many articles about the health benefits of many supplements, I have accumulated a cupboard full of supplements, many of which I don’t take every day or only take occasionally for special circumstances.
I got on to selenium with Coq10 from some article that I don’t even remember and have been taking them faithfully every day, only because they happened to be in the front of the cupboard.
Now I see that the benefits may be more important than I thought. This is important to me because of the conflict between maintaining a high-protein diet recommended for the elderly and methionine restriction.
I believe one Brazil nut a day will meet your selenium requirements. Like the OP I was surprised by Matt Kaberlein’s comments. I love his no bullshit attitude and he’s right, the supplement industry is rife with salesmenship. Keep in mind, though, that he is a scientist and he’s only looking at things that extend lifespan. While many in this forum have similar aspirations, supplements have other valid uses. I think there is consensus that it’s very hard to meet your magnesium requirements with whole foods because farmland has been stripped of it by overfarming. Adele Davis used to say that the human body was like a sponge and it can be slightly moist or full of water. Like many here I probably take too many supplements out of an abundance of caution that my diet is inadequate. I am planning on doing a Genova Metobolom test to see exactly what i might need. Question: how can pure oil squeezed out of a cod not taste fishy? And why is that equated with bad? It must be highly processed to have no taste.
Canned cod liver isn’t processed at all except for the canning and maybe heating the (sealed) cans. It really doesn’t taste fishy all, neither does fresh soused herring but once prepared it starts to go bad really fast. Good fresh herring tastes creamy and silty like the sea but if you keep it prepared in the fridge even, it starts going bad very fast within hours they will get a fishy (but not in a good sense) taste