They have excellent reviews.
Someone on here was concerned about what the filler was… ahh yes silicon dioxide… it actually is good for bones too.
All I have… and my positive results.
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Iodine.
If I could only take one supplement, it would be this — because iodine is foundational to cellular function across the entire body, not just the thyroid.
It’s concentrated in key organs like the thyroid, breast tissue, ovaries, testes, prostate, and brain, where it’s used for hormone production, antioxidant activity, cellular metabolism, and even gene expression regulation. Iodine is also involved in the production of iodolipids, which may have anti-cancer and antimicrobial properties — especially important in epithelial tissues (breast, prostate, colon).
What makes iodine even more critical today is our exposure to competing halogens — bromide, fluoride, and chloride — through water, food packaging, and possibly air pollution. They can displace iodine in tissues and impair thyroid function and other iodine-dependent processes.
The body cannot produce iodine, and unless you’re eating iodine-rich seaweed or seafood frequently, it’s easy to become insufficient.
I personally avoid most sea-based things, and I don’t rely on iodized salt due to inconsistent dosing (also difficult to get enough as we’re only eating 4-8g of salt/day).
Second would be gelatin or collagen (if that’s counted as supplement) — and third would be vitamin D, which I can at least partially get from sunlight.
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But if it’s only one? Iodine.
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Thank you for sharing your thoughts about Iodine, which has been way off my radar when it comes to “ranking” most vital supplements.
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Can you elaborate, what dosage where do you get it? What type? Lithium orthonate?
Vitamine C
Because it is the foundation.
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When the atypical cell is stressed, either, from an inside the cell process or outside the cell stressor. Generally two things can happen. 1. The cell carries on in a “nothing to see here” fashion, or, 2. The cell initiates a self-destruct immune assisted suicide, Apoptosis. And then needs to be replaced with either a neighboring daughter cell or a stem cell.
Lithium can influence this process in a roundabout way. It upregulates an important (but not star of the show cellular pathway) GSK3. Up regulation in effect makes the cell a little “tougher” to stress, with the end result (hopefully) being less unnecessary Apoptosis.
I take 2 mg of Lithium Orate a day, divided am/pm. I buy it from Life Extension. When ever I get to talk about life extension and why I look 15 years younger than I am, I always mention 2 drugs (Rapamycin & Dasatinib) and 2 supplements (Lithium & Feistein)
Here’s a few cool posts to check out. Thanks for your question Patty.
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I disagree with the idea that there are only two options to stress.
What else are you doing/using for your osteopenia? I will be doubling up my taurine now.
The gal who did my DEXA said take daily Vitamin K2 and Calcium supplement. Thats it.
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Thank you, I’m on it
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No amount of supplements will be effective unless osteoblast/osteogenicn activity is stimulated.
Weight loading, or osteogenic loading, refers to the stress placed on bones during weight-bearing activities like running, jumping, or weightlifting. This stress compresses the bone matrix, triggering bone cells to absorb more calcium and minerals, which increases bone density and strength.
Here is nice podcast to listen to:
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Mouse, thank you for the timely and in depth answer… I have been taking lithium but not nearly enough. You are very knowledgeable…
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I think most of nutrients in this thread can be acquired from daily life activity, D3, B12, Magnesium, Omega-3, Taurine, Glycine, Collagen…
It may take a lot of effort to optimize diet, but it’s not completely impossible to get at least the necessary amount of these.
For example,
Magnesium can be get from eating lots of leafy green.
Glycine (collagen) can be get from eating certain part of pork.
Omega-3 can be get from eating oily fish and flaxseed oil.
What’s more,
Methyl group, like TMG, maybe take choline from egg instead.
As to herbal supplement, like L-theanine, take herb directly.
NAD+, healthy lifestyle naturally maintains better level of NAD+.
mTOR and AMPK signal pathways, use fasting and CR to get some similar effect.
If I could only take one supplement, then it must be the one can hardly get enough dose from natural sources.
I think these substance almost impossible to get enough dose (therapeutically) from food or drinks but they do have some benefits and may contribute to healthy aging, listed by importance I believe:
- Creatine
- Glucosamine
- Astaxanthin
- Hyaluronic Acid
I’ll choose creatine if I can only choose one.
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I am torn between Astaxanthin and taurine; today I’d probably say Astaxanthin of the two.
I asked ChatGPT O3 and it said glucosamine seems the most defensible of non-pharmaceuticals. That wasn’t on my radar so I’ll have to look into that.
Ignoring common vitamins like b12 since that’s too boring 
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Even more proof of just how far away we are from AGI/ASI.
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The problem with this sort of question is that if you are deficient in something taking it really helps. B12 may be boring, but best not be deficient.
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I’m not going to offer an opinion about the single most beneficial supplement (I have no clue). But I think it’s interesting to see so many different answers in this thread . . . that means that the vast majority of people here are wrong (but think everyone else is wrong, instead).
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Or that various people have various favourite supplements that fit their lifestyle and genetics best.
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Why do we have to assume there is only one ultimate supplement? I doubt that’s true. I believe that everyone needs a cocktail of supplements.
Think of it like food. Is there one ultimate food that you can live on without eating any other foods? Steak? Milk? Broccoli? I would hazard a guess that if you only subsisted on one food for your entire life, you would live a miserable and short existence!
You need a combination of supplements/medications for health and lifespan.
- Cure deficiencies (you have to find out what YOU are deficient in).
- Jump the CVD hurdle (BA, Ezetemibe, statins, PCSK9i, SGLT2i, etc…)
- Work on subduing the other horsemen of death (diabetes, cancer, dementia, etc…)
You need to do 1 and 2 before working on 3.
This thread is kind of like sharing what we think is the best pick for category #3.
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