Which supplement would you take if you only could take one?

#41

The gal who did my DEXA said take daily Vitamin K2 and Calcium supplement. Thats it.

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#42

Thank you, I’m on it

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#43

No amount of supplements will be effective unless osteoblast/osteogenicn activity is stimulated.
Weight loading, or osteogenic loading, refers to the stress placed on bones during weight-bearing activities like running, jumping, or weightlifting. This stress compresses the bone matrix, triggering bone cells to absorb more calcium and minerals, which increases bone density and strength.

Here is nice podcast to listen to:

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#44

Mouse, thank you for the timely and in depth answer… I have been taking lithium but not nearly enough. You are very knowledgeable…

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#45

This is my favorite; they sell them at Costco

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#46

I think most of nutrients in this thread can be acquired from daily life activity, D3, B12, Magnesium, Omega-3, Taurine, Glycine, Collagen…

It may take a lot of effort to optimize diet, but it’s not completely impossible to get at least the necessary amount of these.

For example,
Magnesium can be get from eating lots of leafy green.
Glycine (collagen) can be get from eating certain part of pork.
Omega-3 can be get from eating oily fish and flaxseed oil.

What’s more,
Methyl group, like TMG, maybe take choline from egg instead.
As to herbal supplement, like L-theanine, take herb directly.
NAD+, healthy lifestyle naturally maintains better level of NAD+.
mTOR and AMPK signal pathways, use fasting and CR to get some similar effect.

If I could only take one supplement, then it must be the one can hardly get enough dose from natural sources.

I think these substance almost impossible to get enough dose (therapeutically) from food or drinks but they do have some benefits and may contribute to healthy aging, listed by importance I believe:

  1. Creatine
  2. Glucosamine
  3. Astaxanthin
  4. Hyaluronic Acid

I’ll choose creatine if I can only choose one.

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#47

I am torn between Astaxanthin and taurine; today I’d probably say Astaxanthin of the two.

I asked ChatGPT O3 and it said glucosamine seems the most defensible of non-pharmaceuticals. That wasn’t on my radar so I’ll have to look into that.

Ignoring common vitamins like b12 since that’s too boring :slight_smile:

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#48

Even more proof of just how far away we are from AGI/ASI.

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#49

The problem with this sort of question is that if you are deficient in something taking it really helps. B12 may be boring, but best not be deficient.

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#50

I’m not going to offer an opinion about the single most beneficial supplement (I have no clue). But I think it’s interesting to see so many different answers in this thread . . . that means that the vast majority of people here are wrong (but think everyone else is wrong, instead).

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#51

Or that various people have various favourite supplements that fit their lifestyle and genetics best.

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#52

Why do we have to assume there is only one ultimate supplement? I doubt that’s true. I believe that everyone needs a cocktail of supplements.

Think of it like food. Is there one ultimate food that you can live on without eating any other foods? Steak? Milk? Broccoli? I would hazard a guess that if you only subsisted on one food for your entire life, you would live a miserable and short existence!

You need a combination of supplements/medications for health and lifespan.

  1. Cure deficiencies (you have to find out what YOU are deficient in).
  2. Jump the CVD hurdle (BA, Ezetemibe, statins, PCSK9i, SGLT2i, etc…)
  3. Work on subduing the other horsemen of death (diabetes, cancer, dementia, etc…)

You need to do 1 and 2 before working on 3.

This thread is kind of like sharing what we think is the best pick for category #3.

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#53

Literally there is no evidence if any of these supplement can prolong lifespan/healthspan for human.
Everyone here is simply doing human experimentation on themself…definitely would be various choice.

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#54

There are some like taurine and astaxanthin that we can reasonably expect to help in preventing/delaying cancer based on strong animal research.
Then there are supplements like omega 3 that probably help with CVD based on human research.

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#55

New Study: Zinc May Be Connected to Better Aging

I was taking zinc pill every 3 days for a year… being careful to not take too much.

Now doing a low dose zinc gummy every day for the past month or so.

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#56

I take zinc 4 times a week too. Not sure how much copper I should supplement in addition to that.

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#57

I take a 15mg zinc tablet 3 times a week. I don’t bother with copper - copper is very abundant in food, especially vegetables, so if your intake of veggies is reasonable, you should not become copper deficient. I am also wary of overdoing copper - it’s not as bad as iron, but not something I’m eager to supplement with, unless I suspect I have a copper deficiency - the list of adverse outcomes with copper accumulation is pretty extensive. Zinc you don’t want to overdo, but it’s much easier to be deficient on a plant predominant diet, so supplementing modestly makes sense, just to avoid deficiencies. Taking big doses of supplemental zinc does not show benefits. Just avoid deficiencies.

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#58

I agree on being careful with zinc. I do supplement with copper. I test quite low probably from drinking.

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