This has good starting information from our Admin. I’ve read on here that generally speaking morning is a good time just in case it interferes with sleep. That’s what I’ve been doing the last 3 months until today when I took it late afternoon and I’m still awake! Live and learn I suppose.
You may want to read this thread on “Bioavailability” of rapamycin, and how to improve it. I usually take it with a higher fat meal (e.g. sardines… in the morning) for about a 30% increase in bioavailability. Rapamycin can impact sleep if you take it later in the day (and for some people it impacts sleep no matter when they take it).