Yes they will in the stomach before reaching the lower intestine. This is part of the reason bioavailability is 13-15%. I don’t know how much boost you’d get bypassing stomach. For someone who dosent want to tinker with GFJ, and is looking for some boost yet reproducible dosing, this might work. Of course, can just take more as well.
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Are you getting Biocon or Zydus from India? The guy from India from whom I’ve been thinking of ordering is telling me to stick with Zydus because Biocon is in trouble.
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You may have mentioned this already - but have you ever done a blood sirolimus level test? Some people have mentioned they can get these free in Canada (I guess its part of the typical treatment protocol for anyone taking siroilmus in Canada and covered by the national healthcare system by default)…
Did you do trough level? Or did you try to get the peak blood sirolimus level too?
Yes I did one test several months ago with Rapamycin.store capsules, and got a reading <2. I did trough first, and post dosing every 30 minutes for 2 hrs. The Cmax tests were surprising, no signal. I never did rationalize what was the root cause.
I am in the midst of exploring yet again, and will be doing a test next month.
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Are you finding it easy to get a blood sirolimus test in Canada? Or does it depend on your doctor, etc.?
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Regular doctor, impossible. My functional medicine doctor, who works at the edges of the system, is supporting my longevity journey. I don’t know if all FMD’s would be as compliant. I have built a relationship based on science…I bring him interventions, we discuss, he generally approves.
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Wow, this is great info. I saw on previous post regarding Colon cancer and Sehgal using 1mg daily of Rapamycin to hold of his stage 4 colon CA. Just enough to hold of on mTORC1 and not mTORC2?
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I started with Biocon. They are not in actual trouble, certainly less trouble than Pfizer often gets into. I switched to Zydus because they have a slightly better reputation. If money were an issue I would have no problem sticking with Biocon as the quoted price is almost half of the Zydus brand. I used Biocon Rapacan for several months and I think it is a good product.
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My doctor just gets pi**ed when I bring scientific papers to his attention. To be clear, most of the doctor’s I have seen are much the same in this regard. I’m still looking for a good primary physician that takes my insurance plan.
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I may be able to help with this one. Some blunt points that hopefully are not excuses, but may help clarity. Its really hard dealing with patients that are smarter than you:). Medicine has many guard rails that make it difficult to think outside of the box from legal terms like, " standard of care" to insurance companies restrictions on what it will pay for off label or investigational treatments. My son just graduated from medical school and will have about 400K in debt that he will let accumulate interest while he is in a 5 year surgery residency. He then will go into a world of needing to see high volumes of patients to make up for a declining reimbursement from the insurance companies, sky rocketing malpractice insurance and many sleepless nights operating on trauma patients. All of this forces most of physicians to stay in our lane and try to survive:)
To address scientific papers presented by patients. In the old days, information was filtered through physicians to their patients. Now the patients can get the information as fast if not faster than the docs. I truly love my job now, but it took years of customizing my practice to be able to feel comfortable to practice outside of the box, read bench mark research results that have not made it to medical journals for clinical application and help patients weigh out risk and benefits of alternative approaches that may not be widely available.
Sorry, I don’t know if that was helpful or just a therapy session for me. I promise there will be a good fit for you out there. You may have to search outside of an insuranced based practice to find it.
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David
Well put and very true.
There are several issues involved here. One is the nature of the medical student, usually very scientific and fact oriented. They prefer concrete answers.
Find appendicitis and remove it.
Find pneumonia and treat it.
Even in prevention it’s only very proven interventions that capture the attention. Exercise, mammograms, colonoscopy.
Now consider the interests of those on this site. Not nearly as black and white, very grey actually.
Much of it quite controversial and involving a certain degree of risk.
Rapamycin once a week for longer life! Really?
Not your standard doctor’s cup of tea. Even if they weren’t under incredible time and financial constraints, the interest just isn’t there.
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So true! One of the keys is, believe it or not, all doctors are potential patients 
I have many medical professionals that come see me that are totally against hormone replacement until they can not sleep, have hot flashes and night sweats, start to gain weight rapidly and have lost energy and motivation. I help simplify their options - Do nothing, try non-hormone options and try hormone options. Most choose hormone options because the risks of 8 more breast cancers out of 10,000 and 12 more episodes of heart disease out of 10,000 based on studies using synthetic hormones ( which I don’t use) vs. 100% feeling like crap to the point they are coming to see me to help them with something they are against. I think what most people on this site realize is that there is a definite risk of taking Rapamycin, hormones, supplements, peptides, nootropics, exercise, fasting eat., but there is a much higher risk of doing nothing.
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You’re right, but they’re different animals.
On the one hand you have someone feeling lousy and desperate, but on the other they feel perfectly fine and you’re talking to them about an immunosuppressive drug.
Thank you! I have realized the pressure doctors are under and the tremendous debt load many of them have. Luckily, my doctors have been smart if not willing to go off-topic. The only reason I have changed doctors is they retire or die.
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I agree, without symptoms, Rapamycin is a reach depending on your age. Unfortunately we also live in a world where you can have people that feel fine, but have genetic markers for heart disease - ApoE4, MTHFR with elevated CRP and CIMT studies that show plaque and thickened inflamed arteries and the cardiologist says that it is a waste of time to order any of that and to let them know when they have symptoms. I think for hormones, most probably should have a symptom issue to take on the risks.
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Yeah, when they’re in ER. Western medicine is a SICK-CARE model…NOT prevention.
If you want to increase your chance of living a longer and healthier life…the responsibility falls on yourself.
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I hate to say it, but I totally agree.
Scour the literature, weigh the evidence, share your ideas on this site so that they can be challenged, and follow your own symptoms and biomarkers.
Take your health into your own hands and then use specialists as a source for advanced testing.
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The manufacturer of the enteric capsules responded to my query. They referred me to their dissolution report.
Here is the Definition of dissolution, from USP.org :
Dissolution is the process in which a substance forms a solution . Dissolution testing measures the extent and rate of solution formation from a dosage form, such as tablet, capsule, ointment, etc. The dissolution of a drug is important for its bioavailability and therapeutic effectiveness.
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What Indian pharmacy do you use? And how do you make direct contact with them? I find India mart to be very confusing.
You can skip Indiamart.com now, just go to our page with the list of reliable online pharmacies
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