Vaccines for longevity

Wasn’t there a finding for the flu vaccine that you saw the pleiotropic protective effects only after 3-4 doses, i.e. 3-4 years of a flu shot?

It’s possible that you need to maintain the immunity effect to access the other benefits. Also let us remember the UK biobank findings for hep A vaccine, and the immunity effect of that vaccine seems very long (20+ years), maybe even lifelong. Meanwhile there’s the situation with tuberculosis where you do better with repeated vaccinations(?). Shingrix pleiotropic effects seem to attenuate after about 6 years, while the immunity lasts about 10. Tetanus and tdap vaccines have a roughly 10 year immunity period, but the pleiotropic effects are stronger in the beginning and attenuate with time. Based on that I personally have elected to get the tdap every five years. There are mixed reports on the immunity period for pneumococcal vaccines, but my plan is to get it every ten years - mind you, at 66 I don’t have much lifespan left, lol, so every 10 years means very few such periods - it’s a different calculation for a younger person.

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A nice summary of what we know / how we know that vaccines don’t cause autism, even though I’m sure I’m mostly preaching to the choir here.

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