Could you post a link to this device, please? @medaura
Here you go. Looks like it went down $10 since I bought it. It’s pretty cheaply made, incredible margins. But it does the trick. It definitely entrains that frequency as I keep hearing it in my head once I shut it off.
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The 2 that we have are a little more pricey - but I’m also testing them for whether to recommend to patients.
The Koushicare - I like - here is a well done review on it.
The Symbyx Helmet is the other one we have (I’ve got a 5% of coupon if anyone wants this). Here is a great review from a patient with PD - but also should work for AD or MCI as should the Koushicare.
With each of these we’ve seen improved (substantially) sleep scores and specifically higher % of sleep in each of REM and Deep. Parkinson’s Patient talking about helmet. The physicians who did the phase II trial (phase III ongoing now) are here.
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That’s great. Do any of the studies see that too?
How long and what time of day do you do it?
I suspect there is some data on that - but right now a whole bunch of testimonials - and my wife and I have had consistent changes that only occur when we wear it prior to bed. We usually do the helmet M/W/F and add to that KoushiCare 30 minutes before bed, then last the vagus nerve stimulator. We saw most of the improvement with just the KoushiCare, the vagus nerve stimulator only adds a little - but we’ve not tried that as monotherapy.
Videos of note on the Symbyx are here:
https://symbyxbiome.com/blogs/symbyx-blog/5-years-of-continue-light-therapy-use-for-parkinsons-trial-results-now-published|
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Why does the reviewer say Gamma Ray? I hope it’s not actual gamma rays 
probably battery doesn’t have enough to juice to generate gamma rays anyway.
Isn’t this supposed be just very long wavelength infra-red light therapy ?
I believe it is gamma radiation and penetrates about 3 cm beyond skull into brain is what Symbyx claims.
@desertshores Sorry for the misspeak. Hate when that happens - yes it is 40 hz frequency of light, and some devices add sound or vibration (the Koushicare has intermittent vibration). Yes the gamma waves are a frequency in the brain 30-100 hz and the best data looks like 40 hz helps the glymphatics - and it does seem to improve mitochondrial function in the brain, and at least on the symbyx helmet, their scientists believe it gets increased activity 3 cm below the skull.
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This is very interesting. I was curious about the difference between men and women mentioned in that article but not specified, so I did some searching, and it seems according to the paper the overall reduction was 20%, but ladies who received the vaccine experienced a 31% relative reduction in dementia risk, while men saw a 6% reduction. Huge result then for women.
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I personally found NMN very useful for getting rid of jetlag when I fly from Hong Kong to the USA. It’s completely gone when I travel and use NMN. That in itself is amazing.
I also notice an energy bump. I mix the pure powder with EVOO in my morning shot (of EVOO).
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No, no, no. Gamma radiation would be dangerous, and the rays would penetrate much deeper, and such a machine would be illegal for home use. It is the 809-900nm IR light wavelengths that penetrate ~3 cm into the skull.
We are actually talking about gamma brain waves.
“Gamma brainwaves, with frequencies between 30 and 100 Hz, are associated with heightened cognitive functions like focus, concentration, and memory, and are sometimes called “super-learning” waves.”
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Ha, I did a double take too when I read, “gamma radiation.”
Thanks for the good stuff in this thread! I decided to see what it would take to get my sirolimus serum levels to 3ng/mL @ 100 hours based on the Dementia protocol. I took 12mg of 1mg sirolimus (Zydus) and @ 100 hours its barely detectable @ 1.5ng/mL. I’ll try again in a couple weeks but now I’m considering testing for peak as well as @ 100 hours.
I’ve seen recommendations for determining peak values anywhere between 2-3 hours and 24 hours (to allow time for integration). What are other folks doing and is there a best practice in the community?
When do you take the NMN - before the flight, during or after?
I take it after I arrive in the morning. I mix it with EVOO, black pepper and turmeric in a morning shot. I take this shot every morning even when I’m not traveling.
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So 1.5 ng/mL with this dose, most likely has your half life being quite rapid. If you were my patient, I’d probably look at just adding 8 oz GFJ 4 hours before and 4 oz at the time of taking it - and go to 5 mg. Alternatively, going up to 15 mg and retesting. I am not giving you advice, but just saying what my approach would typically be. There are other items to consider with taking GFJ (for example interactions with other medications you might be on - with some statins being affected).
Certainly consult with your doctor before changing anything.
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Urolithin A (probably 1g) (https://pubmed.ncbi.nlm.nih.gov/38753870/
(Liposomal ?) EGCG (https://www.nature.com/articles/s41467-022-32951-4 Has problems with the BBB.
Ginkgo Biloba (https://link.springer.com/article/10.1007/s10787-023-01164-6. So lower the BBB.
See also this article on UroA and EGCG n mice models. https://www.mdpi.com/2073-4409/11/17/2660
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I’ve been watching Urolithin A for a while, I also found the last article interesting on the addition of EGCG.
As with everything in this space, I wish we had more human data with so many of these items specifically focused on neurodegenerative decline.
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How hard would it really be to setup an observational study? This is an, unfortunately, very common and severe condition. These are three commonly available supplements (four if you want to throw in curcumin). The mice on the UroA+EGCG combo actually saw an increased time to solve the water maze, because they stopped to play in the water after finding the platform. Seems promising.
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I understand None of this is ‘medical advice’; this is a communal experience forum. 
Having stated that, I appreciate your input. I have been thinking about experimenting with GFJ and simply skipping my statin (10mg rosuvastatin) on dose day. I’ll give that a shot and post an update. Thank you!
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