Yes - we cover that in the animal study risks section. In organ transplant patients taking rapamycin daily it has been shown to be reversible when they stop taking rapamycin.
Regarding the impact of sirolimus on sperm, there was a recently published a case report on a 36-year-old male kidney-transplant recipient treated by an immunosuppressive regimen that contained sirolimus. He presented with dramatic, reversible sperm impairment. He initially (for 3 months) 2 mg/day of sirolimus associated with 10 mg/day of prednisone, 200 mg/day of cyclosporine, and then for 33 months 7 mg/day of sirolimus and 10 mg/day of prednisone. During this time he could not get his wife pregnant. When he stopped taking sirolimus, he could and did get his wife pregnant.
I haven’t seen any people reporting this issue with pulsed, periodic dosing of rapamycin.