I’ve been tracking those biomarkers for at least five years and used a different formula for biological age. The gap has definitely grown since starting rapamycin. My thought is that those estimators are heavily influenced by two things: overall inflammation and the health of the cardio system. I have an extremely low CRP score, which I put down to 1. good genes 2. lifelong runner 3. ectomorph with BMI of 20 4. 31 inch waist (believing that belly fat is where the inflammation tends to accumulate) 5. supplements such as beta-glucan to reduce inflammation 6. making sure the gut is healthy with LOTs of fiber feeding the bacteria there 7. frequent saunas (see dr. Rhonda Patrick on saunas) and 8. cold water therapy a la wim Hof, which challenges the immune system.I eat more or less low-carb and my blood chemistry is good (e.g. TG 70 HDL 71) After a piece in the Financial Times many years ago about why London bus drivers had much higher incidence of heart disease than the ticket takers who were on their feet all day, I bought a stand up desk and try not to sit much during the day. Oh, and i have a dog who requires long walks.
I had 950 total testosterone even after doing 10mg/week regular rapamycin
Your information is strong confirmation of Peter Attia’s assessment that one should first optimize nutrition and exercise (and sleep and emotional health) and after you get these fundamentals right, look for even greater effectiveness from exogenous molecules (ie. rapamycin, etc.).
@RapAdmin
Hello
I am a 24 year old male and I have a longevity doctor in the area who I talked to in regards to starting rapamycin. He said via Dr. Blagosklonny and other experts he talked to that I could start now since I am close to 25. I was wondering if you had any thoughts on starting this young? If it would even benefit me right now or if I should wait a little longer( I turn 25 in August). This doctor would obviously do blood work and everything before hand, but just curious on thoughts.
Thanks
If I were you, and I had any safety concerns, I’d probably go for a less frequent dose (e.g. once a month), or longer rapa breaks. That way I’d imagine there would be higher benefits to risk ratio.
I’d also maybe focus on building muscle – I regret not exercising and building muscle in my 20s because it seems like the easiest in that age.
Well I would start at 1mg once a week, and then slowly work my way up.
I do a lot of longevity related training such as zone 2 cardio or I do body weight / KB work. I do a lot of gymnastic work and yoga as well. I think the thing I really want to improve on is diet. I eat relatively healthy but I feel that can always improve. Just hard to know what is the right thing to do as there so much conflicting research out there. I fast and time restrict my eating as well but again there is conflicting data on when the best time of day to break that fast is or to consume your meal.
We’re not medical doctors here - so keep that in mind and we are all just stating our unprofessional opinions.
I think it would depend. If a person is 24 years old, pretty athletic and healthy, eats well and exercises frequently - then I think the person is unlikely to gain much from rapamycin in the next few years, and little to no risk in delaying until 28 or 30 years old.
If on the other hand, I was a not athletic, didn’t eat that healthy (avoiding simple carbs like sugar, etc.), and perhaps slightly overweight or worse, your life is high stress - then I think there could be a case for starting lower dose rapamycin periodically as part of a move towards getting healthier overall (in which case more exercise, better diet, and being a healthy weight would all be important parts of the equation).
But like everything - there is a risk reward calculation to be done by people at any age starting rapamycin. Rapamycin is not a risk-free drug… so you need to learn as much as you can about rapamycin, and work with your doctor and try to figure out what is the best balance for you.
I am very healthy and athletic. I have done plenty of research( thanks to a lot of your linked research articles). I just wasn’t sure if it would really benefit me much at this point, also I havent had kids yet, so not sure if its worth getting on now, or waiting a couple years.
In your situation, waiting is probably the best choice. the state of the science is moving forward relatively quickly these days - so the longer you wait, the better information you will have to make your decisions. the “opportunity cost” of waiting for you (because you are still very young) is minimal I think.
I second this disclaimer. We’re just a bunch of dudes on the internet.
Yep, look at this stack of Ray Kurzweil from just some years back. His writings had gotten me interested in transhumanism and longevity, but a lot of his extensive supplements (knowing what we know now) seems unnecessary and wrong-headed.
Even metformin which was a poster-child of safe longevity interventions we have now realized is unlikely to be helpful and can even come in the way of someone who’s otherwise practicing healthy habits. While biohacking is fun, doing something wrong and causing damage that is hard to undo would be the risk to keep in mind. If I was your age, I think I’d stick to the basics (of developing healthy habits w.r.t diet, sleep, exercise), and I’d closely track biomarkers. With any new interventions, I’d be cautious and understand the mechanisms very well and then deploy it on an as-needed /short-term basis. Also dosing intervals are often once daily for almost all medications, but it’d help to look at the half-life and sometimes stretch the intervals accordingly so that you don’t develop tolerance.
Btw, I don’t mean to be preachy here. This is also a note to myself as I’m 34 which I believe is old but also significantly lower than the median healthspan. For instance I have begun experimenting with semaglutide, but I want to only maximize benefits with lower doses first and then, I intend to take long breaks from it when possible.
Do you have any signs of aging?
I am just curious what makes you want to try geroprotective drugs?
There are few people trying geroprotective therapy like our ages.
I am in similar age with you
I try rapamycin because my hairs slowly turn gray since 20~25 year, that’s a strong motivation that I am willing to take risks of trying rapamycin
Disclaimer: It’s not a recommendation, it’s just my personal self experiment
I am now in 20mg per month, I choose a rather longer interval partially because I don’t want to interfere with my weight training, and partially because I found it has less side effects on me
I have no signs of aging. I might be balding a little bit, but outside of that I have no health issues or show any signs of aging. I was interested more for preventative medicine and honestly I got introduced to a lot of this stuff as I have a 6 year old leonberger/St bernard mix and I was looking at things I could do for him to help ensure he has a good healthspan.
Alot of the way I train/style my life is for prehab/preventative care , less so than having issues or specific things I need fixed.
Saw on twitter today:
Interesting twitter post by Blagosklonny today, where he states that he thinks people should start rapamycin at age 25:
I suspect he is right, as all development is complete by that age.
i saw some posts from younger men that taking rapamycin reduce their libido.
No, the best age to take rapamycin is earlier than 25. Fuck development. Fuck sexual reproduction. Fuck male sex hormones.
I think I mildly CR’d myself + became veg*n early in life to the point that it SLIGHTLY stunted my growth and halted development of some secondary sex characteristics, and I don’t give a crap about sex, I’d rather live forever than reproduce (though reproduction is not DIFFICULT for me if I chose it). if someone wants to be 16 forever, LET THEM be 16 forever.
LOL,
I will say my goal for rapamycin isnt to live forever, I just wanted to have a good healthspan.
Review the following paper;
“No limit to maximal lifespan in humans: how to beat a 122-year-old record”