I recently saw a dermatologist for some flakiness and dryness around my eyes (and also some other spots that could be syringomas). He prescribed tacrolimus ointment 0.1%. I used this around my eyes and it cleared it up very quickly! He also said I could use it on my face in general. The price wasn’t bad ($30 for a tube)
Has anyone else had experience with tacrolimus on the skin? Does it have the same anti-aging benefits as sirulimus? Would it help keep beard hair from turning gray? When I go for my follow up, should I make a request to instead get Sirolimus ointment? Or is this an uncommon ointment to get from a doctor?
you will not a get a topical Sirolimus RX unless you have tuberous sclerosis,
just stick to tacrolimus, it’s great RX
best solution for you gray beard… shave it
Tacrolimus is quite different than rapamycin / sirolimus (despite the similarity of the names). Tacrolimus is not a targeted Mtorc1 inhibitor like rapamycin. Though Tacrolimus is (orally) an immune suppressant. I’ve seen no research that would suggest that Tacrolimus has any of the anti-aging skin benefits that sirolimus has shown (in a few studies).
Yeah, context matters. Either way, I definitely wouldn’t try Hyftor (Rx sirolimus/rapamycin gel) for anti-aging purposes because the concentration of rapamycin is orders of magnitude higher than what’s been used in the clinical study of topical rapa/aging (0.2% for Hyftor, 0.001% in the Drexel anti-aging study).
This dermatologists uses and recommends 0.1% to 0.2% for anti-aging. The Drexel study was only one study. There have been many studies with rapamycin skin cream ranging from 0.001% to 0.2% with no significant negative side effects ( as I recall): Davin Lim on topical sirolimus -- better for aging skin than tretinoin?
Have there been other studies with topical rapa showing anti-aging skin benefits? Since the Drexel study showed benefits specifically for aging skin, I don’t know if jumping up to 200x the concentration is a good idea just because there aren’t any apparent short-term side effects. Hopefully it’s a good thing and clearly people are doing it, but it would be nice to get some data. It might explain why I didn’t really see any changes with the 0.001% creams I’ve made in the past.
Jeremy, Some months ago I used it on my face and neck for about 2 to 3 months in a row applied once daily to see if it would give me any benefit. I did this after my morning workout shower, not at night. I used it sparingly and rubbed it in thoroughly, but it still left my face looking somewhat greasy and it left my shirt collars greasy. Both of these things were irritating, so I stopped. I didn’t notice any improvement in wrinkles or skin tone during this trial, but maybe it requires 6 months of more.
Oh, there seems to be a “black box” warning for Tacrolimus Ointment, not that it is currently valid, but I have kept it in mind because it mentioned possible cancers.
I have used topical sirolimus 0.2 % and tretinoin 0.1% mixed in Cerave base 1:20 or so dilution over the face and body for the past few monhts. Visually getting good results but with occasional acne cropping up which is in line with imunosuppressive effects of the rapamycin. Benzoyl peroxide 10% always on stand by.
The Tacrolimus helped with the flaky dandruff around my eyes. Unfortunately the syringomas are still there. But the dermatologist said the best way to get rid of them is to remove them. I have a follow up this Monday, so I hope to find out for sure.
