Before I read this, I was also thinking along those same lines.
Regardless of age. I tend to think if you are dosing 3mg or less you should probably dose weekly. Otherwise, it’s probably not doing much. But that’s just my thoughts.
Many of us are constantly revising our own dosing strategy. There just isn’t enough human data. Mostly anecdotal. As far as frequency, it seems like most are torn between once a week and every two weeks. I’m currently tapering up my dose weekly but (as of today) intend to do an every 10 day schedule. And, to try to make it more simple to stay on schedule, I’ll take a dose on the 10th and 20th of each month. And (depending on the length of the month) on the last day or 1st day month. That means some doses might be 9 days or 11 days apart but that’s ok.
You are right about zero data for now. My reasoning is that if young ppl plan to take Rapa for life, it has to be a small dose from time to time. Rapa does suppress immune system and the bigger the dose the more suppression. Just logically, immune system shouldn’t be suppressed all life beginning from your 20s. Occasional small dose is like prophylactics. Cannot wait to see some research data on that.
Thanks. If you take a dose as small as 0.5 mg/w, then I wonder about the level of mTOR inhibition you get and whether you might actually get the same level with 25m of empagliflozin per day or a weekly GLP1RA injection (exenatide, semaglutide, etc.). It might be safer as well (at least we have more data). And it’s easier to get a prescription for that, too.
But assuming you take 0.5 mg/w in your 20s, then what would be the dose escalation schedule as you age?
I am getting a bit more skeptical of Rapamycin over time. I want to hear about it improving some biomarker, like apoB or cholesterol… blood pressure, or whatever. Mostly mice studies.
Taking rapamycin 6 months improved every biomarker on Levine and AI3.0 scale for myself. I avoided every infection I was exposed to in this period. It messed my lipids a bit for a while, same with glucose control, both improved beyond baseline. My BP remained stable. I did once weekly dosing of 5-6 mg and currently testing 1mg/daily for two weeks and one week off (don’t have any measurable evidence it is better or same, just observationally seems better for my autoimmune problems).
Yes, I believe it is important to take rapamycin not as a cure but as prevention. Iit is best to have metabolic health in check before taking rapamycin. And starting early enough to avoid age related diseases. I don’t think it can reverse them, just delay.
Interested thing happened; everyone in my house hold (3 people) came down with a fever, runny nose and dry cough. I was the only one who didn’t get sick. I took 5mg Rapamycin 3 days before they started showed symptoms. I have been in the house for the last 2 days with them. They are still sick 5 days later and I’m still fine.no symptoms at all. Rapamycin definitely didn’t suppress my immune system otherwise I would have gotten sick? Is there any studies showing Rapamycin can boost your immune system against flu/cold in small intermittent doses?
Happens to me all the time. Rapamycin is great for viral immunity seems. There are some studies, on this. I was exposed to many viruses in the last months where other were sick, even when virus vas quite virulent and did not get sick. I also had close brush twice with Covid, when I was talking to people infected with symptoms for hour or so in my office, really close contact and did not get it.
But I hear bacterial infection is another story. I have an anecdotal experience. Just recently I was traveling and had a food poisoning, I had some oysters and tuna sashimi, just few hours later I was feeling sick with high fever, took antibiotic and was all right the next morning. People I was with that ate the same were not sick immediately but it took them few days to develop same symptoms. At the end they all had to take antibiotic. So in a way I presented much quicker reaction, much more serious that made me take antibiotic fast and solve it.
Wow. I started rapamycin at 27 and I am almost now 30 in a couple of months. Time sure flies! A little nervous approaching my 30s but hopefully starting rapamycin in my 20s will slow everything down!
Decided to add topical sirolimus cream to my anti aging stack.
I use 0.2% sirolimus cream that is compounded by a pharmacy ($120 for 30g and it lasts me a little over 3 months and that is also using it on my neck). Expensive but my private health insurance does cover a portion of it
Also using Tretinoin cream some nights as well in addition to the rapamycin cream.
Still taking rapamycin weekly. I did pause for a few weeks after I had some tooth surgery but back on track now. 4mg weekly. Acarbose 50mg with carb rich meals (generally 1-2 50mg acarbose a day as I don’t consume high carb every meal).
Blood work is excellent, muscle gains are great, so far so good!
Thanks for the update! Do you plan to have kids at some point? Sirolimus has been shown to lower male fertility. It seems reversible but I just wonder what is/would be your strategy for that.
Thanks for sharing these. But from what I remember transplant patients are recommended to stop rapamycin for 1 to 3 months before trying to conceive. No?
