I took my fist 14mg dose on Thursday. I felt like the energizer bunny for days, it’s was fantastic!
But, unless I’m getting sick, which I don’t think I am, there is a side effect that is making me reconsider a higher 14 day dose, vs weekly dosing.
My ear feels like it’s slightly clogged (enough so that I was going to make an appt with the doc, but then I realized this might be the rapa). I also have a little more phlegm in my throat (only noticeably when I am lying down). A touch sniffly too.
You are correct! I had planned to take 12, but Claude said 12 would be ideal and 14 would be acceptable, so I just did it knowing anything negative would be short lived.
The symptoms, if related, and I think they probably were, only lasted a few days. All gone now. The positive feelings I had were phenomenal. I still feel pretty good but just not as OTT energetic.
I swapped from every 2 weeks back to every week and now I have a fever and infection of some kind in my mouth.
Might be a coincidence but I think not. I suppose my body cannot reliably handle once a week rapamycin.
I kept seeing promising evidence that once a week rapamycin isn’t immunosuppressive but I do have autoimmune conditions that likely put me in a different category.
I think if you notice this happening to yourself then look at increasing the frequency between doses, or even eliminating it entirely possibly. I don’t think getting infections all the time is conducive to longevity!
Once every 2-4 weeks at 1-3mg is probably safe for me with very low risk.
I went to GP who gave me antibiotic but it’s not doing a whole lot. I’m looking to go to dentist or hospital and get a proper swab test done to figure out what is going on.
Interesting and counterintuitive. Rapamycin is supposed to enhance oral health, through two mechanisms: affecting the oral microbiome and bone remodeling. If so - and there are of course the famous mice trials as well as personal anecdotes from people including on this site - then perhaps whatever infection you have in your oral cavity is less likely to be driven by the classic periodontitis or gingevitis pathogens. You might have something different going on. Also, if you have autoimmune conditions, classically rapamycin tends to alleviate those by tamping down on overactvie inflammatory response - in that scenario one would hypothesize that more frequent dosing ought to have a more positive impact. But as your experience shows, we are all individuals and have specific profiles. Hope you recover soon and you find a dosing protocol that works for you!
@AustraliaLongevity Is the infection a flat white circular ulcer on your gum or buccal mucosa? if so it may be a common side effect of rapa called an aphthous ulcer. It won’t get better with antibiotics.It will resolve on it’s own. About 20% of people get them with rapa.
I have found that 2mg/wk of Rapa has cleared my myalgia to Repatha. Literally has saved my life. My question. Is there anyone who is on Rapa unable to handle the statin myalgia? It is not clear from the many many comments who has myalgia and who has found Rapa has cleared the myalgia. Or maybe everyone on Rapa didn’t realize that it was the Rapa that allowed them to tolerate statins? Just curious. I will test statins next month with 2mg of Rapa.
I get utter exhaustion the day after 2-3 mg. Usually take at 5-6pm Friday and Saturday will be a write of , Sunday mostly as well. My friend who is a PA said maybe I need the rest but it’s made it so I’m a little afraid of the downtime.
Is 1 mg weekly enough to do much of anything? 190lbs. Maybe 1 mg every 5 days. Douse the exhaustion fatigue get better as yo get used to it. Maybe I need a 50-75mg Modafinal to offset the fatigue Thought on fatigue?
I too get hit with the fatigue on Sundays the day after taking Rapa. But it’s a nice fatigue and I think I actually do need the rest. Mondays I feel amazing.