Do you worry about it. That can affect stress and glucose
Without.
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What appears to have changed slightly is your insulin sensitivity. You are having an insulin response to the food intake and that is what is driving the glucose back to your baseline. It appears you are driving it a bit lower than before. Are you taking an SGLT2i or acarbose per chance?
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No Acarbose or SGLT2i, no Metformin or Berberine.
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Hi @LaraPo
As promised, I am back to share that nothing out of the ordinary happened with my glucose levels today
I have my CGM on and took 8mg of rapa. My CGM only showed a little variation that was typical with eatingā¦ nothing like what you saw.
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Thanks Beth! My glucose reading is not out of the ordinary as well. It elevates after eating (and Rapa) as expected and then drops. Itās in fact a normal reading. It usually goes up to 150 (higher than ideal) after my carb loaded meal and then falls to 70-80, sometimes to 90, within an hour. I would probably try to add some little fat like avocado to my smoothie to flatten glucose curves. What surprised me was that Rapa did not negatively affect my glucose (no pseudo-diabetes). Iām just curious how many ppl have pseudo-diabetes while taking Rapa.
What were your exact parameters if you do not mind providing those. When you take Rapa, whatās the highest that your BG goes to? And then how soon does it drop and whatās the lowest reading it reaches? Could you be a little more specific?
On the other hand, your dose is 8mg and mine is 0.5 mg - so we should not even try to parallel it. Itās surprising though that your BG does not move much after such a big dose. Does it stay flat naturally or with meds?
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Iāve been feeling fantastic since getting up to 6mg a week. The rest of my week is quite anabolic in comparison to my rapamycin dosing day so itās a really good thing to throw in.
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Iām an open book so happy to share anything.
Fwiw, without medication, Iāll easily spike to 170-220 when eating, even if it contains fat. That was also pre-rapa, so rapa did not do that to me. My a1c has always been fine, so my attempt to lower these spikes was after I learned they might contribute to heart disease, which I have.
Iām on dapagliflozin, and I take acarbose too.
At times I take low dose retatrutide (I am apoe3/4 so I try to get some in for hopeful brain effects). I havenāt noticed my dose doing anything to my spikes (meaning, I have plenty of weeks when I donāt take it and nothing stands out to me). I also realize this means I might not be getting much in the way of brain benefits 
Now that Iām on dapa and acarbose, my glucose only breaks through 140 maybe 1-3x per week (I donāt pay that much attention due to it not being a frequent problem for me anymore). My target of below 140 is something I got from John Hemming.
Here is my chart from yesterday. I went out to dinner, so I ate later than I normally would. I donāt have the specific time, sorry, but I took my rapa dose when I was already aprox at 120 from my lunch. Iām also happy to do another test for you next Sat and get more glandular. Just PM me with any specific things you want me to look for.
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Thanx Beth! I was interested in how high it goes immediately after you take Rapa. But you are on glucose control meds, which I didnāt take into account at first. In your case, your meds do work well. I donāt take any meds for glucose and trying to achieve a healthy balance naturally through combining the right foods and supplements with the right Rapa dose and timing it all right as well. Iām pleasantly surprised that my small daily Rapa dose doesnāt elevate it much or keeps it high during the day. Iām trying new for me Rapa dosing and it looks like it works well. Thanks again 
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Just sharing the odd side effect my husband gets. He will get night fever/sweats.
At first his doctor was worried and didnāt think it would be from the rapa, so he did do a bunch of labs to rule out anything else.
Heās now gone on and off enough times that is he convinced itās definitely related. He now takes 4mg most weeks instead of 6mg, so itās better, but some weeks it pops up enough that he still takes breaks.
Also, while I have youā¦. Iām having a cracked filling replaced with a crownā¦ because this is all teeth, unlike a root canal, can I assume I donāt need to skip taking rapa?
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I canāt promise that it is of no consequence but Iāve had crowns without stopping rapa with no adverse effect. I also canāt imagine why it would be a problem so I wouldnāt skip.
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I have noticed a slight increase in fasting glucose and therefore also tested Cāpeptide. Which came in on the lower side. I wonder if others in the forum follow c-peptid. And what experinces you might have?
Since rapamycin can raise glucose levels, this change might not necessarily reflect insulin resistance but could instead be due to reduced insulin output ā a sign of a ātiredā pancreas.
When fasting glucose rises, two main mechanisms can cause it: (1) insulin resistance (tissues need more insulin) or (2) reduced insulin production from the pancreatic Ī²ācells (the pancreas cannot make enough insulin). Cāpeptide is released together with endogenous insulin and therefore is a practical marker of how much insulin the pancreas actually produces; low Cāpeptide indicates reduced Ī²ācell output, while normal or high Cāpeptide suggests compensation for insulin resistance.
Low Cāpeptide requires a different testing protocol than an isolated high fasting glucose; it calls for stimulated Cāpeptide testing and antibody screening to assess Ī²ācell reserve and cause, not just repeat glucose measurements.
GLP-1 receptor agonists could be the drug to choose.
ācotreatment with a GLP-1 receptor agonist completely prevented TAC
induced Ī² cell dysfunction and partially prevented SIR-induced Ī² cell dysfunction.ā
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The herd left rapamycin last 12 months:
Bryan Johnson (extreme hacker but successful one), Peter Attia (exercise manic), Peter Diamandis (chancer, newsletter seller)
Did Peter fully drop it or is cycling rapa? Havenāt heard this before.
Itās funny I started taking rapamycin right as Bryan Johnson said it made him less healthy. I find it makes me feel acutely younger on the days I dose it. I wish I could take it daily, I canāt wait until we have things that can give us that feeling every day.
I have almost no doubt rapamycin is successful in humans for antiaging at least in some ways.
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Not trendy anymore, but thereās actually been more convincing data for rapamycin over the last year or so.
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