Side Effects of Rapamycin (part 2)

Do you worry about it. That can affect stress and glucose

Without.
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What appears to have changed slightly is your insulin sensitivity. You are having an insulin response to the food intake and that is what is driving the glucose back to your baseline. It appears you are driving it a bit lower than before. Are you taking an SGLT2i or acarbose per chance?

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No Acarbose or SGLT2i, no Metformin or Berberine.

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Hi @LaraPo

As promised, I am back to share that nothing out of the ordinary happened with my glucose levels today

I have my CGM on and took 8mg of rapa. My CGM only showed a little variation that was typical with eating… nothing like what you saw.

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Thanks Beth! My glucose reading is not out of the ordinary as well. It elevates after eating (and Rapa) as expected and then drops. It’s in fact a normal reading. It usually goes up to 150 (higher than ideal) after my carb loaded meal and then falls to 70-80, sometimes to 90, within an hour. I would probably try to add some little fat like avocado to my smoothie to flatten glucose curves. What surprised me was that Rapa did not negatively affect my glucose (no pseudo-diabetes). I’m just curious how many ppl have pseudo-diabetes while taking Rapa.

What were your exact parameters if you do not mind providing those. When you take Rapa, what’s the highest that your BG goes to? And then how soon does it drop and what’s the lowest reading it reaches? Could you be a little more specific?

On the other hand, your dose is 8mg and mine is 0.5 mg - so we should not even try to parallel it. It’s surprising though that your BG does not move much after such a big dose. Does it stay flat naturally or with meds?

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I’ve been feeling fantastic since getting up to 6mg a week. The rest of my week is quite anabolic in comparison to my rapamycin dosing day so it’s a really good thing to throw in.

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I’m an open book so happy to share anything.

Fwiw, without medication, I’ll easily spike to 170-220 when eating, even if it contains fat. That was also pre-rapa, so rapa did not do that to me. My a1c has always been fine, so my attempt to lower these spikes was after I learned they might contribute to heart disease, which I have.

I’m on dapagliflozin, and I take acarbose too.

At times I take low dose retatrutide (I am apoe3/4 so I try to get some in for hopeful brain effects). I haven’t noticed my dose doing anything to my spikes (meaning, I have plenty of weeks when I don’t take it and nothing stands out to me). I also realize this means I might not be getting much in the way of brain benefits :frowning:

Now that I’m on dapa and acarbose, my glucose only breaks through 140 maybe 1-3x per week (I don’t pay that much attention due to it not being a frequent problem for me anymore). My target of below 140 is something I got from John Hemming.

Here is my chart from yesterday. I went out to dinner, so I ate later than I normally would. I don’t have the specific time, sorry, but I took my rapa dose when I was already aprox at 120 from my lunch. I’m also happy to do another test for you next Sat and get more glandular. Just PM me with any specific things you want me to look for.

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Thanx Beth! I was interested in how high it goes immediately after you take Rapa. But you are on glucose control meds, which I didn’t take into account at first. In your case, your meds do work well. I don’t take any meds for glucose and trying to achieve a healthy balance naturally through combining the right foods and supplements with the right Rapa dose and timing it all right as well. I’m pleasantly surprised that my small daily Rapa dose doesn’t elevate it much or keeps it high during the day. I’m trying new for me Rapa dosing and it looks like it works well. Thanks again :blush:

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