Yes Repatha is a PCSK9i, but it also causes similar muscle pain as statins(but the muscle pain is via a different pathway from statins). Just not as frequent as statins-but is listed as the 3rd most common side effect after runny nose and inj site pain. A low dose Rapamycin(2mg) seems to have stopped my Repatha muscle pain. Not sure if it will help statins.
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Did you initially start on a higher dose of Rapa and titrate down? Iām curious why you settled on the 2mg dose. If I do ever go back on it, I was considering a lower dose than the 6mg/wk I was on for a couple months, but stopped due to mouth sores and a cut that had healing issuesā¦
I had a friend who tried rapamycin and had the same experience, it completely wiped him out. I wonder if this issue (or association) is due to some type of genotype issue, or other issue. My friend tends to have higher blood pressure already which he tries to control but may be inconsistent on. He also has more central adipose tissue (ie. a bit of a āgutā) and probably higher inflammation issues related to this. I wonder if these factors may influence response to rapamycin. I donāt think there is any data yet, but something to consider. Anyone else see any other possible correlations to āpoor respondersā to rapamycin?
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I donāt remember if I shared this, but many months ago my husband tried taking it, but he finally threw in the towel.
At night, he would get a fevers and night sweats.
His doctor, who was confident it wasnāt caused by rapa, ran a bunch of labs to rule anything else out.
When he stopped, the fevers went away, and hen he went back on, they came back. He experimented 2 different times. The first time he was on 6mg weekly, and the second attempt was at 4mg.
Heās a super fit guy who makes me look like the Pillsbury Doughboy, so body composition was not a contributing factor in this case.
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Iām one of those people. So is the fatigue a sign that rapamycin is actually repairing the body, or is it simply a side effect?
In mouse studies, fatigue is usually a sign of aging. I really wish I felt energetic after taking rapamycin. Unfortunately, I feel extremely exhausted every time I take it.
Then there are those who feel nothing as a result of taking rapamycin. Iām now on week 14 of taking 8mg once per week. Same protocol, every Saturday first thing in the morning on an empty stomach and then nothing but matcha for the next 2 hours or so. And I know I absorb rapa, because even at 6mg, 50 hours later my blood levels of sirolimus are like 5.6 ng
Yet I feel absolutely nothing subjectively from taking it. Neither the day of, or on subsequent days. I do see side effects - minor pimple on the nose or chin (I never get pimples otherwise). These come and go, some weeks there, some weeks nothing. Honestly, it feels like Iām taking nothing - good thing I can get blood tests otherwise Iād suspect the pills were duds.
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I guess Iāll chime in also with a bit of more nuanced N=1 based on time I take it. When I take rapa (usually 5mg) before bed I wake up tired but not necessarily in a bad way, Itās like being very relaxed but not motivated I almost like the feeling, kind of hard to explain. When I take it in the morning/during the day, I feel absolutely nothing. I do however always get very mild flu like symptoms for the first two days in the mornings (when I wake up) but symptoms disappear soon after I wake up. BTW, 5mgs is my sweet spot as I have never gotten mouth sores from this dose. I used to do 6mgs and would often get mouth sores (very uncomfortable) so I switched to 5mgs and havenāt had a case in over 4 months now.
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It is odd the range of side effects that people get from taking rapamycin. I wonder why this is and what it means.
Personally I have never felt any side effects except diarrhea the next day after taking massive doses.
It has never affected my sleep or made me tired. In fact, when I first started taking rapamycin, I often felt slightly elated the next day. Now I feel nothing.
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I have often wondered if some side effects might be ameliorated by lengthening the dose interval enough to create a rapamycin free period, especially for older individuals. Other important benefits might also follow.
The study most often cited for āimmune rejuvenationā did not test continuous weekly sirolimus exposure. It tested brief mTOR inhibition followed by complete withdrawal.
The 2014 Mannick trial gave adults aged 65 and older six weeks of everolimus, followed by a two-week drug-free interval before administering an influenza vaccination. Vaccine responses improved by approximately 20%, and PD-1āexpressing CD4 and CD8 T cells declined. The immune benefit was therefore expressed after treatment had stopped, not merely while the drug was present.
The 2018 trial similarly treated older adults for six weeks with low-dose mTOR inhibitors (different arms using Everolimus and/or dactolisib), followed by withdrawal. Similar to the 2014 study, the most effective regimen enhanced antiviral gene expression, improved influenza-vaccine responses and reduced reported infections during subsequent follow-up.
These trials do not prove that the washout was necessary because they did not randomize participants to vaccination on-drug versus off-drug. They did establish that a transient course can produce immune benefits that survive drug clearance.
Given the other forms of evidence that a strong immune system accounts for much of the variance in surviving intact into old age, a regimen that created drug free intervals might lessen side effects and produce the most useful effects. Even a months on followed by months off regimen is not ruled out by current evidence.