I would normally suspect cardiac issues, but I wore a holter monitor during the time of the edema (due to other issues I had going on) and they found nothing out of the ordinary. I have also had multiple blood tests and have ruled out immune disfunction, glucose issues and other things that may have been obvious. I am on canaglifozin and have been dosing acarbose at 100 mg per meal. I am very fit, do strength training 4 times per week, watch my diet (for the most part) and otherwise feel fine.
As a side note I wrote a note to Matt Kaeberlein and asked him if lymphedema was possible with rapamycin. Here was his response:
Iād think about probability not possibility. Itās possible youāll develop stomach bleeding from aspirin and die, but not probable. IMO, itās improbable that low dose weekly rapamycin would cause unilateral lymphedema but certainly itās possible. Very infrequent if so.
I have been doing more research and found that there are also cases were Sirolimus is being used to treat lymphedema with some success. Iām very confused right now and have decided to go off Rapa for a couple of months to see if this resolves.
fragile toe ā¦nails . i have blood under both big toe nails . i think it was originally from some injury as wear flip flops all the time so often stubbing toes but normally the blood should have cleared out after a short time like at most a few days as usual but after rapa has been there for months
Re: Empag; I had read a journal article on the potential benefits for remodeling of myocardium and the kidney, and I believe my GFR has improved. I dont have the citation handy.
I donāt know if you all remember when I reported that Dove microbiome soap is the only one that has a low enough ph to not disrupt the skin barrier function. This came from Lustgartenās book.
There is a lawsuit now about to go forward that accuses Unilever of putting things in this soap that are known skin irritants:
I wondered what all the chemicals were in that soap. Or should I call it a cleaning chemical ( instead of soap )? Honestly I still use it every night and I think itās great for my skin. They say in the suit that if you rinse thoroughly it wonāt happen. I guess Iāll rinse more thoroughly.
Anyway, my wife saw something about this in the news and I thought Iād report.
topical rapa did good.-less gray and a little darker esp where i applied it and eyebrows less gray and a little darker. canāt say for sure whether rapa injections did as much or anything noticeable but probably did but more subtle than direct topical
taking doxycycline makes me quite naseous and sick like. If you are taking doxy that may be what is making u feel sick. - in fact likely more so than rapa at least for me
I was taking doxycycline for malaria prevention extensively for prolonged periods and was never nauseous. I remember also having really nice skin and never got any of the travel diarrhea too.
I donāt think there is a standard delay time that weāve identified in any discussion. I think a few days is what my experience (only had one, several years ago), and I think Iāve heard something like this from others here.
Here are some other conversations, there seems to be a fairly wide range from a day after to 6 days after the doseā¦
Just a quick reminder that herpes labialis (cold sores) are not the same as canker sores. This is important distinction because antivirals like acyclovir or valtrex can prevent cold sores and have zero effect on canker sores.
My father, who is 76, just started Rapamycin. He is experiencing the same euphoric fatigue that I do. This leads me to believe that the effects of Rapamycin may be related to genetic factors. Has anyone else experienced the same side effects of Rapamycin usage as blood relatives?
Thanks everyone for your comments on side-effects. I have read about half of them and they are very good perspective.
I am currently at 8 mg once each week after dosing for about two months. I worked up to that dose. Given side effects mentioned below I am going to stay at this dose for another few months, then take a break for a couple weeks.
My side effects are relatively mild but still noticeable. I have skin tingling that starts out most strongly after dosing, mostly in my hands, face and ears, as well as my scalp. This tingling persists for nearly the entire seven days until the next dose, but gradually declines. I also have moments of a sort of neurological euphoria (hard to describe) once in awhile. I have had these in the past after being very sick and recovering, so that seems a good thing. It it definitely stimulative for me so I am glad I started the habit of taking it in the morning.
P.S.: Forgot to mention I get just a couple of itchy hives on my hands a couple days after dosing. They last for a day or two and then gone.