fragile toe …nails . i have blood under both big toe nails . i think it was originally from some injury as wear flip flops all the time so often stubbing toes but normally the blood should have cleared out after a short time like at most a few days as usual but after rapa has been there for months
Check out my acute angioedema story… mine was DIRECTLY caused by Rapamycin.
Kira, where could I read your story?
Any reason you chose empaglaflozin vs canagliflozin?
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Re: Empag; I had read a journal article on the potential benefits for remodeling of myocardium and the kidney, and I believe my GFR has improved. I dont have the citation handy.
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Good to know, thanks. I’ll look into it.
I don’t know if you all remember when I reported that Dove microbiome soap is the only one that has a low enough ph to not disrupt the skin barrier function. This came from Lustgarten’s book.
There is a lawsuit now about to go forward that accuses Unilever of putting things in this soap that are known skin irritants:
I wondered what all the chemicals were in that soap. Or should I call it a cleaning chemical ( instead of soap )? Honestly I still use it every night and I think it’s great for my skin. They say in the suit that if you rinse thoroughly it won’t happen. I guess I’ll rinse more thoroughly.
Anyway, my wife saw something about this in the news and I thought I’d report.
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topical rapa did good.-less gray and a little darker esp where i applied it and eyebrows less gray and a little darker. can’t say for sure whether rapa injections did as much or anything noticeable but probably did but more subtle than direct topical
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taking doxycycline makes me quite naseous and sick like. If you are taking doxy that may be what is making u feel sick. - in fact likely more so than rapa at least for me
I haven’t tried doxy with rapa yet, so I don’t know.
I was taking doxycycline for malaria prevention extensively for prolonged periods and was never nauseous. I remember also having really nice skin and never got any of the travel diarrhea too.
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That’s a very impressive improvement
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I have found that the information and guidance from other members of this forum to be even more useful to me than the rapamycin.
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What is the typical time delay for a canker sore from a rapamycin dose? I seem to have one that I noticed this morning. I dosed last Friday.
I don’t think there is a standard delay time that we’ve identified in any discussion. I think a few days is what my experience (only had one, several years ago), and I think I’ve heard something like this from others here.
Here are some other conversations, there seems to be a fairly wide range from a day after to 6 days after the dose…
Just a quick reminder that herpes labialis (cold sores) are not the same as canker sores. This is important distinction because antivirals like acyclovir or valtrex can prevent cold sores and have zero effect on canker sores.
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My father, who is 76, just started Rapamycin. He is experiencing the same euphoric fatigue that I do. This leads me to believe that the effects of Rapamycin may be related to genetic factors. Has anyone else experienced the same side effects of Rapamycin usage as blood relatives?
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Thanks everyone for your comments on side-effects. I have read about half of them and they are very good perspective.
I am currently at 8 mg once each week after dosing for about two months. I worked up to that dose. Given side effects mentioned below I am going to stay at this dose for another few months, then take a break for a couple weeks.
My side effects are relatively mild but still noticeable. I have skin tingling that starts out most strongly after dosing, mostly in my hands, face and ears, as well as my scalp. This tingling persists for nearly the entire seven days until the next dose, but gradually declines. I also have moments of a sort of neurological euphoria (hard to describe) once in awhile. I have had these in the past after being very sick and recovering, so that seems a good thing. It it definitely stimulative for me so I am glad I started the habit of taking it in the morning.
P.S.: Forgot to mention I get just a couple of itchy hives on my hands a couple days after dosing. They last for a day or two and then gone.
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At one point (as you may have read earlier in the threads), I thought that my newly diagnosed lymphedema was caused by Rapa. So, I went off it for a couple months and got treatment (lymphatic drainage therapy, etc.) with some significant improvement. Having read a boatload of research and even communicating with Matt K, I think there may have been other insidious factors at work. So…I went back on Rapa. The effects were interesting.
I started back on 5 mg per week with nothing like EVOO or GFJ to boost it. The next couple of days I thought I had taken speed (not that I’ve ever taken speed, I’m just imagining the effects). I was almost relentless at work, buzzing through things I had been putting off for weeks. My mood felt like I had won $10 million in the lottery and no longer had a care in the world. I slept great, felt energetic from waking to sleep. I felt like I was 18. The effects lasted for the better part of 3 days. I had started no other supplements or eaten any differently.
I can only attribute it to the dosing. When I first started I went super slow. 1 mg / week for a couple months, then 2 mg / week for a couple of months, etc. until I got up to 6 mg/ week. Now, after a 2 month hiatus I just started at 5 mg / week. The effects were too drastic to be any type of placebo effect and nothing else in my life had changed other than restarting Rapa. I have to say (almost ashamedly) that I enjoyed it. At 57 it felt like a trip back to my teens energy-wise. On day 4 I seemed to come down to normal. I’m due for my next dose on Monday and am very interested to see what, if anything, will happen.
Anyone else experience this?
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